Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation

Evaluation of the cytotoxicity and genotoxicity of aristolochic acid I – A component of Aristolochiaceae plant extracts used in homeopathy

(2013) Dana Nitzsche et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

THE ROLE OF BIOTRANSFORMATION ENZYMES IN THE DEVELOPMENT OF RENAL INJURY AND UROTHELIAL CANCER CAUSED BY ARISTOLOCHIC ACID: URGENT QUESTIONS AND DIFFICULT ANSWERS

(2012) Marie Stiborova et al.   BIOMEDICAL PAPERS-OLOMOUC

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

(2012) Andrea R Tentner et al.   Molecular Systems Biology

Aristolochic Acid I Induced Autophagy Extenuates Cell Apoptosis via ERK 1/2 Pathway in Renal Tubular Epithelial Cells

(2012) Youjia Zeng et al.   PLoS One

Aristolochia Manshuriensis Kom Inhibits Adipocyte Differentiation by Regulation of ERK1/2 and Akt Pathway

(2012) Dong Hoon Kwak et al.   PLoS One

Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity

(2012) Zhenzhou Jiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells

(2012) Shaohua Zhu et al.   TOXICOLOGY IN VITRO

Aristolochic acid induces apoptosis of human umbilical vein endothelial cells in vitro by suppressing PI3K/Akt signaling pathway

(2011) Hong Shi et al.   ACTA PHARMACOLOGICA SINICA

Glutamate dehydrogenase requirement for apoptosis induced by aristolochic acid in renal tubular epithelial cells

(2011) Victor Romanov et al.   APOPTOSIS

EAPP modulates the activity of p21 and Chk2

(2011) Peter Andorfer et al.   CELL CYCLE

Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2

(2011) Marie Stiborová et al.   TOXICOLOGICAL SCIENCES

Inhibition of Renal NQO1 Activity by Dicoumarol Suppresses Nitroreduction of Aristolochic Acid I and Attenuates its Nephrotoxicity

(2011) Min Chen et al.   TOXICOLOGICAL SCIENCES

Cysteinyl leukotrienes synthesis is involved in aristolochic acid I-induced apoptosis in renal proximal tubular epithelial cells

(2011) Hongyu Yang et al.   TOXICOLOGY

Aristolochic acid I induced oxidative DNA damage associated with glutathione depletion and ERK1/2 activation in human cells

(2011) Feng-Yih Yu et al.   TOXICOLOGY IN VITRO

Microarray analysis reveals the inhibition of nuclear factor-kappa B signaling by aristolochic acid in normal human kidney (HK-2) cells

(2010) Ya-yin Chen et al.   ACTA PHARMACOLOGICA SINICA

MAPK cell-cycle regulation inSaccharomyces cerevisiaeandCandida albicans

(2010) Inês Correia et al.   Future Microbiology

Activation of p53 Promotes Renal Injury in Acute Aristolochic Acid Nephropathy

(2009) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

DNA adducts of aristolochic acid II: total synthesis and site-specific mutagenesis studies in mammalian cells

(2009) Sivaprasad Attaluri et al.   NUCLEIC ACIDS RESEARCH

Inhibition of p38-MAPK Potentiates Cisplatin-Induced Apoptosis via GSH Depletion and Increases Intracellular Drug Accumulation in Growth-Arrested Kidney Tubular Epithelial Cells

(2009) Maria Elena Rodríguez-García et al.   TOXICOLOGICAL SCIENCES

Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity

(2008) Y. Xiao et al.   KIDNEY INTERNATIONAL

Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid

(2008) M. Stiborová et al.   KIDNEY INTERNATIONAL

Involvement of p38 MAPK Phosphorylation and Nitrate Formation in Aristolochic Acid-Mediated Antiplatelet Activity

(2008) Ming-Yi Shen et al.   PLANTA MEDICA

Differential cytotoxic effects of denitroaristolochic acid II and aristolochic acids on renal epithelial cells

(2008) Qing Liu et al.   TOXICOLOGY LETTERS

Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation

(2007) A.A. Pozdzik et al.   KIDNEY INTERNATIONAL