Hepatitis B virus receptors and molecular drug targets

Liver capsule: Entry and entry inhibition of hepatitis B virus and hepatitis delta virus into hepatocytes

(2016) Stephan Urban   HEPATOLOGY

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor

(2016) Florian A. Lempp et al.   JOURNAL OF HEPATOLOGY

The FDA approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide

(2015) Chunkyu Ko et al.   ANTIVIRAL THERAPY

The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B

(2015) Hui-Han Hu et al.   GUT

Towards an HBV cure: state-of-the-art and unresolved questions—report of the ANRS workshop on HBV cure

(2015) Mirjam B Zeisel et al.   GUT

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

The p.Ser267Phe variant inSLC10A1is associated with resistance to chronic hepatitis B

(2015) Liang Peng et al.   HEPATOLOGY

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

(2015) Eloi R. Verrier et al.   HEPATOLOGY

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

(2015) Manabu Kaneko et al.   JOURNAL OF VIROLOGY

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

(2015) Laurent Mailly et al.   NATURE BIOTECHNOLOGY

Host-targeting agents for treatment of hepatitis B virus infection

(2015) Thomas F Baumert et al.   Current Opinion in Virology

Targeting Viral Entry for Treatment of Hepatitis B and C Virus Infections

(2015) Che C. Colpitts et al.   ACS Infectious Diseases

(−)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes

(2014) Hsiu-Chen Huang et al.   ANTIVIRAL RESEARCH

Use of FDA approved therapeutics with hNTCP metabolic inhibitory properties to impair the HDV lifecycle

(2014) Matthieu Blanchet et al.   ANTIVIRAL RESEARCH

Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes

(2014) Stephan Urban et al.   GASTROENTEROLOGY

Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide

(2014) H. Yan et al.   JOURNAL OF VIROLOGY

The role of glypicans in Hedgehog signaling

(2014) Jorge Filmus et al.   MATRIX BIOLOGY

Broadly neutralizing antibodies abrogate established hepatitis C virus infection

(2014) Y. P. de Jong et al.   Science Translational Medicine

Entry of hepatitis B and C viruses — recent progress and future impact

(2014) Thomas F Baumert et al.   Current Opinion in Virology

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

(2013) Koichi Watashi et al.   HEPATOLOGY

Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor

(2013) Shirin Nkongolo et al.   JOURNAL OF HEPATOLOGY

Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide

(2013) H. Yan et al.   JOURNAL OF VIROLOGY

The solute carrier family 10 (SLC10): Beyond bile acid transport

(2013) Tatiana Claro da Silva et al.   MOLECULAR ASPECTS OF MEDICINE

Structure–Activity Relationship for FDA Approved Drugs As Inhibitors of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP)

(2013) Zhongqi Dong et al.   MOLECULAR PHARMACEUTICS

Chronic hepatitis D at a standstill: where do we go from here?

(2013) Alessia Ciancio et al.   Nature Reviews Gastroenterology & Hepatology

Proteoglycans Act as Cellular Hepatitis Delta Virus Attachment Receptors

(2013) Oscar Lamas Longarela et al.   PLoS One

Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

(2013) Fei Liu et al.   PLoS Pathogens

Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes

(2012) Julie Lucifora et al.   ANTIVIRAL RESEARCH

New challenges in viral hepatitis

(2012) David Thomas et al.   GUT

A conformational heparan sulfate binding site essential to infectivity overlaps with the conserved hepatitis B virus A-determinant

(2012) Camille Sureau et al.   HEPATOLOGY

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus

(2012) Tassilo Volz et al.   JOURNAL OF HEPATOLOGY

A New Class of Synthetic Peptide Inhibitors Blocks Attachment and Entry of Human Pathogenic Viruses

(2012) Marcel Krepstakies et al.   JOURNAL OF INFECTIOUS DISEASES

Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis

(2012) H.-C. Huang et al.   JOURNAL OF VIROLOGY

Experimental models and therapeutic approaches for HBV

(2012) Maura Dandri et al.   Seminars in Immunopathology

Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling

(2011) Fuchuan Li et al.   JOURNAL OF CELL BIOLOGY

Peginterferon plus Adefovir versus Either Drug Alone for Hepatitis Delta

(2011) Heiner Wedemeyer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatitis B Virus Requires Intact Caveolin-1 Function for Productive Infection in HepaRG Cells

(2009) A. Macovei et al.   JOURNAL OF VIROLOGY

Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein

(2008) Joerg Petersen et al.   NATURE BIOTECHNOLOGY

Glypicans

(2008) Jorge Filmus et al.   GENOME BIOLOGY