A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

(2015) Sergio Ruiz et al.   Nature Communications

The Histone Deacetylases Sir2 and Rpd3 Act on Ribosomal DNA to Control the Replication Program in Budding Yeast

(2014) Kazumasa Yoshida et al.   MOLECULAR CELL

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Molecular ties between the cell cycle and differentiation in embryonic stem cells

(2014) Victor C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rad51 Regulates Cell Cycle Progression by Preserving G2/M Transition in Mouse Embryonic Stem Cells

(2014) Sang-Wook Yoon et al.   STEM CELLS AND DEVELOPMENT

How unfinished business from S-phase affects mitosis and beyond

(2013) Hocine W Mankouri et al.   EMBO JOURNAL

Lineage specification in the early mouse embryo

(2013) Fredrik Lanner   EXPERIMENTAL CELL RESEARCH

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

(2013) K. J. Neelsen et al.   GENES & DEVELOPMENT

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling

(2013) Matthias Altmeyer et al.   MOLECULAR CELL

High Dub3 Expression in Mouse ESCs Couples the G1/S Checkpoint to Pluripotency

(2013) Siem van der Laan et al.   MOLECULAR CELL

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

(2012) Brian R. Berquist et al.   CANCER LETTERS

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

(2012) Thorkell Gudjonsson et al.   CELL

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

(2012) Rodrigo Bermejo et al.   MOLECULAR CELL

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gap 1 phase length and mouse embryonic stem cell self-renewal

(2012) V. C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels

(2012) Elisia D. Tichy et al.   Stem Cell Research

High Basal γH2AX Levels Sustain Self-Renewal of Mouse Embryonic and Induced Pluripotent Stem Cells

(2012) Valentina Turinetto et al.   STEM CELLS

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Activation of DNA damage response signaling in mouse embryonic stem cells

(2011) Ilya A. Chuykin et al.   CELL CYCLE

Genomic instability in induced stem cells

(2011) C E Pasi et al.   CELL DEATH AND DIFFERENTIATION

The dark side of induced pluripotency

(2011) Martin F. Pera   NATURE

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell cycle adaptations of embryonic stem cells

(2011) A. Ballabeni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types

(2010) T. Ryba et al.   GENOME RESEARCH

DNA Damage Responses in Human Induced Pluripotent Stem Cells and Embryonic Stem Cells

(2010) Olga Momcilovic et al.   PLoS One

Balancing dormant and self-renewing hematopoietic stem cells

(2009) Anne Wilson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage

(2009) Celine Ziegler-Birling et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

(2009) Xin Zhang et al.   JOURNAL OF CELL BIOLOGY

Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis

(2009) R. Sigl et al.   JOURNAL OF CELL SCIENCE

DNA repair in murine embryonic stem cells and differentiated cells

(2008) Elisia D. Tichy et al.   EXPERIMENTAL CELL RESEARCH

Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells

(2008) J.P. Banáth et al.   EXPERIMENTAL CELL RESEARCH

PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA

(2008) Kazuto Sugimura et al.   JOURNAL OF CELL BIOLOGY

Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

(2008) Ichiro Hiratani et al.   PLOS BIOLOGY