DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination

Synthetic viability genomic screening defines Sae2 function in DNA repair

(2015) F. Puddu et al.   EMBO JOURNAL

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection

(2015) D. Bonetti et al.   EMBO REPORTS

Phosphorylation of Sae2 Mediates Forkhead-associated (FHA) Domain-specific Interaction and Regulates Its DNA Repair Function

(2015) Jason Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CtIP tetramer assembly is required for DNA-end resection and repair

(2015) Owen R Davies et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

(2015) Sara N Andres et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The 9-1-1 checkpoint clamp coordinates resection at DNA double strand breaks

(2015) Greg H.P. Ngo et al.   NUCLEIC ACIDS RESEARCH

Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling

(2015) Huan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CtIP tetramer assembly is required for DNA-end resection and repair

(2015) Owen R Davies et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

(2015) Sara N Andres et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining

(2014) Feng-Ling Tsai et al.   CELL CYCLE

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

(2014) R. A. Deshpande et al.   EMBO JOURNAL

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

(2014) Andreas Sturzenegger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection

(2014) James M. Daley et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation-Regulated Transitions in an Oligomeric State Control the Activity of the Sae2 DNA Repair Enzyme

(2013) Qiong Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

PCNA promotes processive DNA end resection by Exo1

(2013) Xiaoqing Chen et al.   NUCLEIC ACIDS RESEARCH

Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity

(2013) M. Levikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship of DNA degradation by Saccharomyces cerevisiae Exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection

(2013) E. Cannavo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling DNA-end resection: a new task for CDKs

(2013) Lorenza P. Ferretti et al.   Frontiers in Genetics

The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1

(2012) Soo-Hyun Yang et al.   EMBO JOURNAL

Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA Complex: A Mechanism for Disentangling Chromosomes

(2012) Petr Cejka et al.   MOLECULAR CELL

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

(2011) Marcel Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes

(2010) Young-Hoon Kang et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

The Full-length Saccharomyces cerevisiae Sgs1 Protein Is a Vigorous DNA Helicase That Preferentially Unwinds Holliday Junctions

(2010) Petr Cejka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporally and Biochemically Distinct Activities of Exo1 during Meiosis: Double-Strand Break Resection and Resolution of Double Holliday Junctions

(2010) Kseniya Zakharyevich et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1–Top3

(2010) Petr Cejka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting

(2010) Woo-Hyun Chung et al.   PLoS Genetics

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

The P. furiosus Mre11/Rad50 Complex Promotes 5′ Strand Resection at a DNA Double-Strand Break

(2008) Ben B. Hopkins et al.   CELL

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Mechanisms of Recombination: Lessons fromE. coli

(2008) Nicole S. Persky et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

(2008) Christian Zierhut et al.   EMBO JOURNAL

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

Functional Interactions Between Sae2 and the Mre11 Complex

(2008) H.-S. Kim et al.   GENETICS

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

(2008) A. V. Nimonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA