On the structure and mechanism of two-pore channels

Tuning the ion selectivity of two-pore channels

(2017) Jiangtao Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

The human two-pore channel 1 is modulated by cytosolic and luminal calcium

(2017) Laura Lagostena et al.   Scientific Reports

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix

(2016) Nina Larisch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+release and Ca2+influx

(2016) Bethan S. Kilpatrick et al.   JOURNAL OF CELL SCIENCE

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

(2016) Lin Tang et al.   NATURE

Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana

(2016) Alexander F. Kintzer et al.   NATURE

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

(2016) Jianping Wu et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain

(2016) D. Jaślan et al.   PLANT BIOLOGY

TPC2 controls pigmentation by regulating melanosome pH and size

(2016) Andrea L. Ambrosio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

A melanosomal two-pore sodium channel regulates pigmentation

(2016) Nicholas W. Bellono et al.   Scientific Reports

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

(2016) Abigail G Garrity et al.   eLife

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

TPC: the NAADP discovery channel?: Figure 1

(2015) Anthony J. Morgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells

(2015) Antony Galione   CELL CALCIUM

Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis

(2015) Jaime S Horton et al.   Channels

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

(2015) M. Ruas et al.   EMBO JOURNAL

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

(2015) Jiangtao Guo et al.   NATURE

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Pleiotropic and Sex-Specific Effects of Cancer GWAS SNPs on Melanoma Risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study

(2015) Jonathan M. Kocarnik et al.   PLoS One

Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

(2014) A. Jha et al.   EMBO JOURNAL

Organelle-specific Subunit Interactions of the Vertebrate Two-pore Channel Family

(2014) Oluseye A. Ogunbayo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

(2014) Chunlei Cang et al.   Nature Chemical Biology

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

(2014) Y. Lin-Moshier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels

(2014) T. Rahman et al.   Science Signaling

Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+

(2014) S. J. Pitt et al.   Science Signaling

A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability

(2014) Chunlei Cang et al.   Nature Communications

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

(2014) B. C. Grabiner et al.   Cancer Discovery

The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP

(2013) Dev Churamani et al.   BIOCHEMICAL JOURNAL

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

Hax-1 identified as a two-pore channel (TPC)-binding protein

(2013) Andy K.M. Lam et al.   FEBS LETTERS

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1

(2012) Volodymyr Rybalchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of plant TPC channels by polyunsaturated fatty acids

(2012) Paul Vijay Kanth Gutla et al.   JOURNAL OF EXPERIMENTAL BOTANY

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

An N-Terminal Dileucine Motif Directs Two-Pore Channels to the Tonoplast of Plant Cells

(2012) Nina Larisch et al.   TRAFFIC

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

(2011) Yaping Lin-Moshier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg

(2011) Timothy F. Walseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-pore Channels Form Homo- and Heterodimers

(2011) Katja Rietdorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

A Novel Calcium Binding Site in the Slow Vacuolar Cation Channel TPC1 Senses Luminal Calcium Levels

(2011) B. Dadacz-Narloch et al.   PLANT CELL

Differential contribution of EF-hands to the Ca2+-dependent activation in the plant two-pore channel TPC1

(2011) Christina Schulze et al.   PLANT JOURNAL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+Currents in Isolated Lysosomes

(2010) Michael Schieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation

(2010) Robert Hooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

Aging: Central role for autophagy and the lysosomal degradative system

(2009) Yogendra S. Rajawat et al.   AGEING RESEARCH REVIEWS

An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles

(2009) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine fromStephaniae tetrandrae

(2009) Lijin Zhang et al.   JOURNAL OF SEPARATION SCIENCE

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Thefou2mutation in the major vacuolar cation channel TPC1 confers tolerance to inhibitory luminal calcium

(2009) Diana Beyhl et al.   PLANT JOURNAL

Two newly identified genetic determinants of pigmentation in Europeans

(2008) Patrick Sulem et al.   NATURE GENETICS