TPC: the NAADP discovery channel?: Figure 1

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

(2015) M. Ruas et al.   EMBO JOURNAL

The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells

(2014) Anna Boccaccio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

(2014) A. Jha et al.   EMBO JOURNAL

Organelle-specific Subunit Interactions of the Vertebrate Two-pore Channel Family

(2014) Oluseye A. Ogunbayo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2

(2014) M. Ruas et al.   MOLECULAR AND CELLULAR BIOLOGY

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa

(2014) Lilli Arndt et al.   MOLECULAR BIOLOGY OF THE CELL

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

(2014) Chunlei Cang et al.   Nature Chemical Biology

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling

(2014) A. Favia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

(2014) Y. Lin-Moshier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants

(2014) W.-G. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+

(2014) S. J. Pitt et al.   Science Signaling

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability

(2014) Chunlei Cang et al.   Nature Communications

The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP

(2013) Dev Churamani et al.   BIOCHEMICAL JOURNAL

Two-pore channels (TPCs): Current controversies

(2013) Anthony J. Morgan et al.   BIOESSAYS

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

Hax-1 identified as a two-pore channel (TPC)-binding protein

(2013) Andy K.M. Lam et al.   FEBS LETTERS

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH

(2013) Yingying Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bidirectional Ca2+signaling occurs between the endoplasmic reticulum and acidic organelles

(2013) Anthony J. Morgan et al.   JOURNAL OF CELL BIOLOGY

Two Pore Channel 2 Differentially Modulates Neural Differentiation of Mouse Embryonic Stem Cells

(2013) Zhe-Hao Zhang et al.   PLoS One

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

The luminal Ca2+ chelator, TPEN, inhibits NAADP-induced Ca2+ release

(2012) Anthony J. Morgan et al.   CELL CALCIUM

NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

(2012) Lianne C. Davis et al.   CURRENT BIOLOGY

Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1

(2012) Volodymyr Rybalchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide isoforms determine compartment-specific ion channel activity

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of endolysosomal Ca2+signalling in health and disease

(2011) Anthony J. Morgan et al.   BIOCHEMICAL JOURNAL

Domain assembly of NAADP-gated two-pore channels

(2011) Dev Churamani et al.   BIOCHEMICAL JOURNAL

NAADP influences excitation–contraction coupling by releasing calcium from lysosomes in atrial myocytes

(2011) Thomas P. Collins et al.   CELL CALCIUM

Vacuolar Ca2+ uptake

(2011) Jon K. Pittman   CELL CALCIUM

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels

(2011) Soichiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

(2011) Yaping Lin-Moshier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg

(2011) Timothy F. Walseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-pore Channels Form Homo- and Heterodimers

(2011) Katja Rietdorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+Mobilization from Lysosomes in Pancreatic Acinar Cells

(2010) François Cosker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+Currents in Isolated Lysosomes

(2010) Michael Schieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels

(2010) P. K. Aley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes

(2010) M. Schieder et al.   Science Signaling

An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles

(2009) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY