Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+release and Ca2+influx

Ca2+/H+exchange by acidic organelles regulates cell migration in vivo

(2016) Manuela Melchionda et al.   JOURNAL OF CELL BIOLOGY

Regulation of TRPML1 function

(2015) Helen Waller-Evans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells

(2015) Antony Galione   CELL CALCIUM

Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels

(2015) Sandip Patel et al.   CELL CALCIUM

BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release

(2015) Qi Cao et al.   DEVELOPMENTAL CELL

Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV

(2015) Soonhong Park et al.   EMBO REPORTS

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

A computational model of lysosome-ER Ca2+ microdomains

(2014) C. J. Penny et al.   JOURNAL OF CELL SCIENCE

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

(2014) L. N. Hockey et al.   JOURNAL OF CELL SCIENCE

Activation of TRPML1 Clears Intraneuronal A  in Preclinical Models of HIV Infection

(2014) M. Bae et al.   JOURNAL OF NEUROSCIENCE

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

(2014) Cheng-Chang Chen et al.   Nature Communications

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

Generation and characterization of a lysosomally targeted, genetically encoded Ca2+-sensor

(2012) Hannah V. McCue et al.   BIOCHEMICAL JOURNAL

Triggering of Ca2+signals by NAADP-gated two-pore channels: a role for membrane contact sites?

(2012) Sandip Patel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The intracellular Ca2+channels of membrane traffic

(2012) Kirill K. Kiselyov et al.   Channels

Direct mobilisation of lysosomal Ca 2+ triggers complex Ca 2+ signals

(2012) Bethan S. Kilpatrick et al.   JOURNAL OF CELL SCIENCE

Phosphoinositide isoforms determine compartment-specific ion channel activity

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1−/− cells

(2011) Fan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acidic Ca2+ stores come to the fore

(2011) Sandip Patel et al.   CELL CALCIUM

Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels

(2011) Soichiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals

(2010) Sandip Patel et al.   CELL CALCIUM

Small Molecule Activators of TRPML3

(2010) Christian Grimm et al.   CHEMISTRY & BIOLOGY

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE