Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies

Stem vs non-stem cell origin of colorectal cancer

(2015) D J Huels et al.   BRITISH JOURNAL OF CANCER

The RB tumor suppressor at the intersection of proliferation and immunity: relevance to disease immune evasion and immunotherapy

(2015) Jack Hutcheson et al.   CELL CYCLE

Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis

(2015) Michael S. Kareta et al.   Cell Stem Cell

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

(2015) Renáta Váraljai et al.   GENES & DEVELOPMENT

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

(2015) Brandon N. Nicolay et al.   GENES & DEVELOPMENT

Origins, genetic landscape, and emerging therapies of small cell lung cancer

(2015) Ekaterina A. Semenova et al.   GENES & DEVELOPMENT

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

(2015) Kazuhiro Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Vemurafenib resistance reprograms melanoma cells towards glutamine dependence

(2015) Jenny E Hernandez-Davies et al.   Journal of Translational Medicine

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

The origin of breast tumor heterogeneity

(2015) A Skibinski et al.   ONCOGENE

NUSAP1expression is upregulated by loss of RB1 in prostate cancer cells

(2015) Catherine A. Gordon et al.   PROSTATE

Clinical development of cancer therapeutics that target metabolism

(2015) B.F. Clem et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts

(2015) Shunsuke Kitajima et al.   STEM CELLS

Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions

(2015) Collene R. Jeter et al.   STEM CELLS

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

(2015) Matthew J. Niederst et al.   Nature Communications

Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification

(2014) Leal Oburoglu et al.   Cell Stem Cell

Mammary stem cells and the differentiation hierarchy: current status and perspectives

(2014) J. E. Visvader et al.   GENES & DEVELOPMENT

Rb suppresses human cone-precursor-derived retinoblastoma tumours

(2014) Xiaoliang L. Xu et al.   NATURE

Redox control of glutamine utilization in cancer

(2014) L Alberghina et al.   Cell Death & Disease

NF-κB Functions in Tumor Initiation by Suppressing the Surveillance of Both Innate and Adaptive Immune Cells

(2014) David J. Wang et al.   Cell Reports

Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch

(2014) Yoshinori Imai et al.   Cell Reports

Looking at plant cell cycle from the chromatin window

(2014) Bénédicte Desvoyes et al.   Frontiers in Plant Science

Metabostemness: A New Cancer Hallmark

(2014) Javier A. Menendez et al.   Frontiers in Oncology

Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation

(2013) Wenbo Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

The multiple connections between pRB and cell metabolism

(2013) Brandon N Nicolay et al.   CURRENT OPINION IN CELL BIOLOGY

The retinoblastoma protein induces apoptosis directly at the mitochondria

(2013) K. I. Hilgendorf et al.   GENES & DEVELOPMENT

RB goes mitochondrial

(2013) L. D. Attardi et al.   GENES & DEVELOPMENT

Loss of RBF1 changes glutamine catabolism

(2013) B. N. Nicolay et al.   GENES & DEVELOPMENT

Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma

(2013) Tongsen Zheng et al.   HEPATOLOGY

Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell division

(2013) Bénédicte Desvoyes et al.   JOURNAL OF EXPERIMENTAL BOTANY

EZH2 Promotes E2F-Driven SCLC Tumorigenesis through Modulation of Apoptosis and Cell-Cycle Regulation

(2013) Roland Hubaux et al.   Journal of Thoracic Oncology

ATM Mediates pRB Function To Control DNMT1 Protein Stability and DNA Methylation

(2013) Awad Shamma et al.   MOLECULAR AND CELLULAR BIOLOGY

Mouse models for lung cancer

(2013) Min-chul Kwon et al.   Molecular Oncology

Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq

(2013) Jennifer J. Brady et al.   NATURE CELL BIOLOGY

Tracing the cellular origin of cancer

(2013) Cédric Blanpain   NATURE CELL BIOLOGY

Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity

(2013) Zhu A. Wang et al.   NATURE CELL BIOLOGY

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

(2013) Anguraj Sadanandam et al.   NATURE MEDICINE

Molecular mechanisms underlying RB protein function

(2013) Frederick A. Dick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

(2013) C Saiz-Ladera et al.   ONCOGENE

Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation

(2013) A L Manning et al.   ONCOGENE

Control of glutamine metabolism by the tumor suppressor Rb

(2013) M R Reynolds et al.   ONCOGENE

Genomic Deregulation of the E2F/Rb Pathway Leads to Activation of the Oncogene EZH2 in Small Cell Lung Cancer

(2013) Bradley P. Coe et al.   PLoS One

An Oct4-pRb Axis, Controlled by MiR-335, Integrates Stem Cell Self-Renewal and Cell Cycle Control

(2013) Stefan Schoeftner et al.   STEM CELLS

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

Twists in views on RB functions in cellular signaling, metabolism and stem cells

(2012) Chiaki Takahashi et al.   CANCER SCIENCE

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

Lysyl Oxidase Is Induced by Cell Density-Mediated Cell Cycle Suppression via RB-E2F1-HIF-1α Axis

(2012) Takaaki M. Goto et al.   CELL STRUCTURE AND FUNCTION

Molecular Pathways: Regulation of Metabolism by RB

(2012) B. F. Clem et al.   CLINICAL CANCER RESEARCH

The Retinoblastoma pathway regulates stem cell proliferation in freshwater planarians

(2012) Shu Jun Zhu et al.   DEVELOPMENTAL BIOLOGY

The retinoblastoma tumor suppressor and stem cell biology

(2012) J. Sage   GENES & DEVELOPMENT

Rb/E2F1 Regulates the Innate Immune Receptor Toll-Like Receptor 3 in Epithelial Cells

(2012) M. Taura et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development

(2012) R Rubio et al.   ONCOGENE

Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis

(2012) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering the retinoblastoma protein phosphorylation code

(2012) Seth M. Rubin   TRENDS IN BIOCHEMICAL SCIENCES

The RB family is required for the self-renewal and survival of human embryonic stem cells

(2012) Jamie F. Conklin et al.   Nature Communications

A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity

(2012) Michelle S. Longworth et al.   PLoS Genetics

Coexpression of Normally Incompatible Developmental Pathways in Retinoblastoma Genesis

(2011) Justina McEvoy et al.   CANCER CELL

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

Common Structural and Epigenetic Changes in the Genome of Castration-Resistant Prostate Cancer

(2011) T. W. Friedlander et al.   CANCER RESEARCH

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

RB1 and p53 at the crossroad of EMT and triple-negative breast cancer

(2011) Zhe Jiang et al.   CELL CYCLE

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

E2F transcription factor-1 regulates oxidative metabolism

(2011) Emilie Blanchet et al.   NATURE CELL BIOLOGY

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

(2011) W. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interleukin 6 receptor is a direct transcriptional target of E2F3 in prostate tumor derived cells

(2011) Stephen J. Libertini et al.   PROSTATE

CC Chemokine Ligand 2 and Leukemia Inhibitory Factor Cooperatively Promote Pluripotency in Mouse Induced Pluripotent Cells

(2011) Yuki Hasegawa et al.   STEM CELLS

pRB, a tumor suppressor with a stabilizing presence

(2011) Amity L. Manning et al.   TRENDS IN CELL BIOLOGY

Local Mesenchymal Stem/Progenitor Cells Are a Preferential Target for Initiation of Adult Soft Tissue Sarcomas Associated with p53 and Rb Deficiency

(2010) Jinhyang Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Transient Inactivation of Rb and ARF Yields Regenerative Cells from Postmitotic Mammalian Muscle

(2010) Kostandin V. Pajcini et al.   Cell Stem Cell

Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts

(2010) Fang Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

Androgens Suppress EZH2 Expression Via Retinoblastoma (RB) and p130-Dependent Pathways: A Potential Mechanism of Androgen-Refractory Progression of Prostate Cancer

(2010) Laura R. Bohrer et al.   ENDOCRINOLOGY

RB's original CIN?

(2010) J. Sage et al.   GENES & DEVELOPMENT

Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift

(2010) Giovanni Ciavarra et al.   JOURNAL OF CELL BIOLOGY

The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression

(2010) Ankur Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Cell of origin of lung cancer

(2010) Kate D. Sutherland et al.   Molecular Oncology

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation

(2009) Awad Shamma et al.   CANCER CELL

Retinoblastoma Has Properties of a Cone Precursor Tumor and Depends Upon Cone-Specific MDM2 Signaling

(2009) Xiaoliang L. Xu et al.   CELL

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Mouse Fibroblasts Lacking RB1 Function Form Spheres and Undergo Reprogramming to a Cancer Stem Cell Phenotype

(2009) Yongqing Liu et al.   Cell Stem Cell

AMP-Activated Protein Kinase Phosphorylates Retinoblastoma Protein to Control Mammalian Brain Development

(2009) Biplab Dasgupta et al.   DEVELOPMENTAL CELL

Keeping an eye on retinoblastoma control of human embryonic stem cells

(2009) Jamie F. Conklin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mutation of the Rb1 Pathway Leads to Overexpression of mTor, Constitutive Phosphorylation of Akt on Serine 473, Resistance to Anoikis, and a Block in c-Raf Activation

(2009) S. El-Naggar et al.   MOLECULAR AND CELLULAR BIOLOGY

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

(2009) Adam J Bass et al.   NATURE GENETICS

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice

(2009) Hongbo Wang et al.   NATURE GENETICS

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

(2009) Elgene Lim et al.   NATURE MEDICINE

Id Proteins Facilitate Self-Renewal and Proliferation of Neural Stem Cells

(2009) Seunghwan Jung et al.   STEM CELLS AND DEVELOPMENT

Soft tissue sarcomas with complex genomic profiles

(2009) Louis Guillou et al.   VIRCHOWS ARCHIV

Rb Depletion Results in Deregulation of E-Cadherin and Induction of Cellular Phenotypic Changes that Are Characteristic of the Epithelial-to-Mesenchymal Transition

(2008) Y. Arima et al.   CANCER RESEARCH

Hematopoietic Stem Cell Quiescence Is Maintained by Compound Contributions of the Retinoblastoma Gene Family

(2008) Patrick Viatour et al.   Cell Stem Cell

Regulation of the PDK4 Isozyme by the Rb-E2F1 Complex

(2008) Michael C. F. Hsieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

(2008) Arthur P. Young et al.   NATURE CELL BIOLOGY