ATM Mediates pRB Function To Control DNMT1 Protein Stability and DNA Methylation

Twists in views on RB functions in cellular signaling, metabolism and stem cells

(2012) Chiaki Takahashi et al.   CANCER SCIENCE

The retinoblastoma tumor suppressor and stem cell biology

(2012) J. Sage   GENES & DEVELOPMENT

A novel retinoblastoma therapy from genomic and epigenetic analyses

(2012) Jinghui Zhang et al.   NATURE

Loss of Heterochromatin Protein 1 Gamma Reduces the Number of Primordial Germ Cells via Impaired Cell Cycle Progression in Mice1

(2011) Kanae Abe et al.   BIOLOGY OF REPRODUCTION

Tip60: Connecting chromatin to DNA damage signaling

(2011) Yingli Sun et al.   CELL CYCLE

Newly identified aspects of tumor suppression by RB

(2011) P. Viatour et al.   Disease Models & Mechanisms

Beyond ATM: The protein kinase landscape of the DNA damage response

(2011) Ariel Bensimon et al.   FEBS LETTERS

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

(2011) W. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of DNMT1 Abundance in Epigenetic Inheritance by Acetylation, Ubiquitylation, and the Histone Code

(2011) C. Bronner   Science Signaling

Regulation of DNA methyltransferase 1 by interactions and modifications

(2011) Weihua Qin et al.   Nucleus

Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts

(2010) Fang Li et al.   Cell Stem Cell

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

(2010) T. van Harn et al.   GENES & DEVELOPMENT

RB's original CIN?

(2010) J. Sage et al.   GENES & DEVELOPMENT

DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination

(2010) Z. Du et al.   Science Signaling

Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation

(2009) Awad Shamma et al.   CANCER CELL

Mouse Fibroblasts Lacking RB1 Function Form Spheres and Undergo Reprogramming to a Cancer Stem Cell Phenotype

(2009) Yongqing Liu et al.   Cell Stem Cell

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

New tales of an old tail

(2009) Jiri Lukas et al.   NATURE

Genome-wide Analysis of the H3K4 Histone Demethylase RBP2 Reveals a Transcriptional Program Controlling Differentiation

(2008) Nuria Lopez-Bigas et al.   MOLECULAR CELL

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE