Metabostemness: A New Cancer Hallmark

Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: New insight into the role of mitophagy in cell stemness

(2016) Alejandro Vazquez-Martin et al.   Aging-US

Impact of MYC in regulation of tumor cell metabolism

(2015) Therese Wahlström et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Tumoral reprogramming: Plasticity takes a walk on the wild side

(2015) Elena Campos-Sánchez et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Epigenetics and cancer metabolism

(2015) Christelle Johnson et al.   CANCER LETTERS

Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy

(2015) Carolina Vicente-Dueñas et al.   SEMINARS IN CANCER BIOLOGY

Metformin: Multi-faceted protection against cancer

(2015) Sonia Del Barco et al.   Oncotarget

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts

(2015) Sílvia Cufí et al.   Oncotarget

Unknown

(2015) Elisabet Cuyàs et al.   Oncotarget

Metabolic Regulation of Redox Status in Stem Cells

(2014) Ester Perales-Clemente et al.   ANTIOXIDANTS & REDOX SIGNALING

Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

(2014) Robert J. Vanner et al.   CANCER CELL

Sox2: Masterminding the Root of Cancer

(2014) Wai Leong Tam et al.   CANCER CELL

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis

(2014) Lindsay E. Wu et al.   CANCER CELL

Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites

(2014) JAVIERABEL MENENDEZ MENENDEZ et al.   CELL CYCLE

Xenopatients 2.0: Reprogramming the epigenetic landscapes of patient-derived cancer genomes

(2014) JAVIERABEL MENENDEZ MENENDEZ et al.   CELL CYCLE

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

(2014) Maria M. Mihaylova et al.   Cell Stem Cell

Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma

(2014) D. R. Borger et al.   CLINICAL CANCER RESEARCH

Dedifferentiation and reprogramming: origins of cancer stem cells

(2014) D. Friedmann-Morvinski et al.   EMBO REPORTS

Cancer Stem Cell Theory and the Warburg Effect, Two Sides of the Same Coin?

(2014) Nicola Pacini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

(2014) Supriya K. Saha et al.   NATURE

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mathematical approaches to modeling development and reprogramming

(2014) R. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling

(2014) Altaf Mohammed et al.   Translational Oncology

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

(2014) D Ciavardelli et al.   Cell Death & Disease

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

(2014) Paula Lopez-Serra et al.   Nature Communications

A stochastic model dissects cell states in biological transition processes

(2014) Jonathan W. Armond et al.   Scientific Reports

Autophagy in stem cells

(2013) Jun-Lin Guan et al.   Autophagy

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Metformin Selectively Targets Tumor-Initiating Cells in ErbB2-Overexpressing Breast Cancer Models

(2013) P. Zhu et al.   Cancer Prevention Research

Statistical Mechanics of Pluripotency

(2013) Ben D. MacArthur et al.   CELL

Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers

(2013) Jian Shu et al.   CELL

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells

(2013) JAVIER MENENDEZ et al.   CELL CYCLE

Metabolome and metaboproteome remodeling in nuclear reprogramming

(2013) Clifford DL Folmes et al.   CELL CYCLE

Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

(2013) BRUNA COROMINAS-FAJA et al.   CELL CYCLE

The mitochondrial H+-ATP synthase and the lipogenic switch

(2013) Alejandro Vazquez-Martin et al.   CELL CYCLE

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

Mitochondrial Regulation in Pluripotent Stem Cells

(2013) Xiuling Xu et al.   Cell Metabolism

Transient Activation of Autophagy via Sox2-Mediated Suppression of mTOR Is an Important Early Step in Reprogramming to Pluripotency

(2013) Shuo Wang et al.   Cell Stem Cell

Chemical Approaches to Stem Cell Biology and Therapeutics

(2013) Wenlin Li et al.   Cell Stem Cell

IDH mutations in tumorigenesis and their potential role as novel therapeutic targets

(2013) Daniel Krell et al.   Future Oncology

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7

(2013) B. B. Madison et al.   GENES & DEVELOPMENT

Mitochondrial Function in Pluripotent Stem Cells and Cellular Reprogramming

(2013) Raul Bukowiecki et al.   GERONTOLOGY

Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate

(2013) V. A. Rafalski et al.   JOURNAL OF CELL SCIENCE

Small molecules, big roles - the chemical manipulation of stem cell fate and somatic cell reprogramming

(2013) Y. Zhang et al.   JOURNAL OF CELL SCIENCE

Exploiting tumor metabolism: challenges for clinical translation

(2013) Matthew G. Vander Heiden   JOURNAL OF CLINICAL INVESTIGATION

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

(2013) Atsushi Terunuma et al.   JOURNAL OF CLINICAL INVESTIGATION

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Deterministic direct reprogramming of somatic cells to pluripotency

(2013) Yoach Rais et al.   NATURE

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

Rare insights into cancer biology

(2013) J Adam et al.   ONCOGENE

Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factors

(2013) M Nishi et al.   ONCOGENE

Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells

(2013) Enza Lonardo et al.   PLoS One

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

(2013) H. A. Hirsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Reprogramming in Cancer

(2013) M. L. Suva et al.   SCIENCE

Quantitative imaging of subcellular metabolism with stable isotopes and multi-isotope imaging mass spectrometry

(2013) Matthew L. Steinhauser et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities

(2013) R. A. Cairns et al.   Cancer Discovery

Expression of the Pluripotency Transcription Factor OCT4 in the Normal and Aberrant Mammary Gland

(2013) Foteini Hassiotou et al.   Frontiers in Oncology

Energy metabolism plasticity enables stemness programs

(2012) Clifford D.L. Folmes et al.   Annals of the New York Academy of Sciences

Nichotherapy for stem cells: There goes the neighborhood

(2012) Jean-Pierre Levesque et al.   BIOESSAYS

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Cancer stem cell dynamics in tumor progression and metastasis: Is the microenvironment to blame?

(2012) Evelyn Fessler et al.   CANCER LETTERS

Metformin and Cancer Stem Cells: Old Drug, New Targets

(2012) F. Bednar et al.   Cancer Prevention Research

Connecting Threads: Epigenetics and Metabolism

(2012) Sayako Katada et al.   CELL

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

(2012) Ahmed F. Salem et al.   CELL CYCLE

Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells

(2012) Alejandro Vazquez-Martin et al.   CELL CYCLE

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal

(2012) Jin Zhang et al.   Cell Stem Cell

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

Aging and reprogramming: a two-way street

(2012) Salah Mahmoudi et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian Sirtuins and Energy Metabolism

(2012) Xiaoling Li et al.   International Journal of Biological Sciences

Sirtuin Catalysis and Regulation

(2012) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The developing cancer stem-cell model: clinical challenges and opportunities

(2012) Louis Vermeulen et al.   LANCET ONCOLOGY

Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism

(2012) Matthew L. Steinhauser et al.   NATURE

An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state

(2012) C. Polytarchou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of cancer: of all cancer cells, all the time?

(2012) Sébastien L. Floor et al.   TRENDS IN MOLECULAR MEDICINE

Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells

(2012) Chang W. Song et al.   Scientific Reports

Metformin limits the tumourigenicity of iPS cells without affecting their pluripotency

(2012) Alejandro Vazquez-Martin et al.   Scientific Reports

Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

(2012) Atsushi Sato et al.   Stem Cells Translational Medicine

The emerging role of fumarate as an oncometabolite

(2012) Ming Yang et al.   Frontiers in Oncology

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

Clinical Implications of Stem Cell Gene Oct-4 Expression in Breast Cancer

(2011) Cai-gang Liu et al.   ANNALS OF SURGERY

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

Energy metabolism in nuclear reprogramming

(2011) Clifford DL Folmes et al.   Biomarkers in Medicine

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

(2011) Claudia Lengerke et al.   BMC CANCER

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types

(2011) D. Iliopoulos et al.   CANCER RESEARCH

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a

(2011) Cristina Oliveras-Ferraros et al.   CELL CYCLE

mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging

(2011) Javier A. Menendez et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

(2011) Athanasia D Panopoulos et al.   CELL RESEARCH

Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions

(2011) Alejandro Vazquez-Martin et al.   DRUG RESISTANCE UPDATES

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells

(2011) Alessandro Prigione et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Inborn and acquired metabolic defects in cancer

(2011) Christian Frezza et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metabolic regulation by p53

(2011) Oliver D. K. Maddocks et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds

(2011) Yanyan Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Co-expression of Oct-4 and Nestin in human breast cancers

(2011) Caigang Liu et al.   MOLECULAR BIOLOGY REPORTS

PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress

(2011) Nirmalya Sen et al.   MOLECULAR CELL

The potential role of nutritional genomics tools in validating high health foods for cancer control: Broccoli as example

(2011) Lynnette R. Ferguson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme

(2011) Amparo Wolf et al.   NEUROBIOLOGY OF DISEASE

Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

(2011) S Floor et al.   ONCOGENE

Sox2 expression in breast tumours and activation in breast cancer stem cells

(2011) O Leis et al.   ONCOGENE

Promoter Hypermethylation Mediated Downregulation of FBP1 in Human Hepatocellular Carcinoma and Colon Cancer

(2011) Mingquan Chen et al.   PLoS One

Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

(2011) Ji-Won Jung et al.   PLoS One

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transdifferentiation of glioblastoma cells into vascular endothelial cells

(2011) Y. Soda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia

(2011) Hsiu-Ni Kung et al.   PLoS Genetics

The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

(2010) Alejandro Vazquez-Martin et al.   BREAST CANCER RESEARCH AND TREATMENT

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

(2010) Elsa Quintana et al.   CANCER CELL

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells

(2010) X. Yang et al.   CANCER RESEARCH

CD44posCD49fhiCD133/2hi Defines Xenograft-Initiating Cells in Estrogen Receptor–Negative Breast Cancer

(2010) Matthew J. Meyer et al.   CANCER RESEARCH

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

(2010) Jacob H. Hanna et al.   CELL

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis

(2010) Sílvia Cufí et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status

(2010) Alejandro Vazquez-Martin et al.   CELL CYCLE

Metformin and cancer: Doses, mechanisms and the dandelion and hormetic phenomena

(2010) Begoña Martin-Castillo et al.   CELL CYCLE

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

Metformin and Energy Metabolism in Breast Cancer: From Insulin Physiology to Tumour-initiating Stem Cells

(2010) A. Vazquez-Martin et al.   CURRENT MOLECULAR MEDICINE

Identification of MicroRNAs Regulating Reprogramming FactorLIN28in Embryonic Stem Cells and Cancer Cells

(2010) Xiaomin Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 connects tumorigenesis and reprogramming to pluripotency: Figure 1.

(2010) Natalia Tapia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells

(2010) Rachel Sarig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer

(2010) S Peng et al.   ONCOGENE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

(2010) Alessandro Prigione et al.   STEM CELLS

Embryonic stem cell markers expression in cancers

(2009) Matthieu Schoenhals et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reprogramming cell fates: reconciling rarity with robustness

(2009) Sui Huang   BIOESSAYS

Acting Locally and Globally: Myc's Ever-Expanding Roles on Chromatin

(2009) N. V. Varlakhanova et al.   CANCER RESEARCH

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis

(2009) C. Maenhaut et al.   CARCINOGENESIS

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

Stem Cell States, Fates, and the Rules of Attraction

(2009) Tariq Enver et al.   Cell Stem Cell

Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures

(2009) Mark H. Chin et al.   Cell Stem Cell

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Metabolic defects provide a spark for the epigenetic switch in cancer

(2009) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Energetics, epigenetics, mitochondrial genetics

(2009) Douglas C. Wallace et al.   MITOCHONDRION

Elite and stochastic models for induced pluripotent stem cell generation

(2009) Shinya Yamanaka   NATURE

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Direct cell reprogramming is a stochastic process amenable to acceleration

(2009) Jacob Hanna et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

(2009) Jochen Utikal et al.   NATURE

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

Systems biology of stem cell fate and cellular reprogramming

(2009) Ben D. MacArthur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis

(2009) X Liu et al.   ONCOGENE

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Epigenetic signatures in stem cells and cancer stem cells

(2009) Hector Hernandez-Vargas et al.   Epigenomics

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

The role of poly(ADP-ribosyl)ation in epigenetic events

(2008) Delphine Quénet et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS