Autophagy-Dependent Secretion: Contribution to Tumor Progression

The roles of phosphoinositides in mammalian autophagy

(2016) Deok-Jin Jang et al.   ARCHIVES OF PHARMACAL RESEARCH

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

(2016) Abhishek D. Garg et al.   Science Translational Medicine

Extracellular ATP and P2X7 receptor exert context-specific immunogenic effects after immunogenic cancer cell death

(2016) A D Garg et al.   Cell Death & Disease

Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death

(2016) F S Salah et al.   Cell Death & Disease

IL13 activates autophagy to regulate secretion in airway epithelial cells

(2015) John D Dickinson et al.   Autophagy

Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy

(2015) Kana Unuma et al.   Autophagy

DNA Methylation of DKK3 Modulates Docetaxel Chemoresistance in Human Nonsmall Cell Lung Cancer Cell

(2015) Leilei Tao et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Vesicular trafficking mechanisms in endothelial cells as modulators of the tumor vasculature and targets of antiangiogenic therapies

(2015) Hannelore Maes et al.   FEBS Journal

Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus

(2015) Koichiro Tsuboi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of Dickkopf-3 overexpression in esophageal adenocarcinoma

(2015) Zhuwen Wang et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

(2015) Paola Maycotte et al.   MOLECULAR CANCER RESEARCH

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABARAPL1 is required for increased EGFR membrane expression during hypoxia

(2015) Tom G. Keulers et al.   RADIOTHERAPY AND ONCOLOGY

Canonical autophagy does not contribute to cellular radioresistance

(2015) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

(2015) Min Zhang et al.   eLife

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian malignancies: A large-scale meta-analysis

(2015) Abhishek D. Garg et al.   OncoImmunology

Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells

(2015) Kamolporn Amornsupak et al.   BMC CANCER

Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination

(2014) Zhenzhen Zhan et al.   Autophagy

Identification of secreted proteins that reflect autophagy dynamics within tumor cells

(2014) Adam A. Kraya et al.   Autophagy

GABA(A) Receptor Pi (GABRP) Stimulates Basal-like Breast Cancer Cell Migration through Activation of Extracellular-regulated Kinase 1/2 (ERK1/2)

(2014) Gina M. Sizemore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3

(2014) Sangeeta Nath et al.   NATURE CELL BIOLOGY

The two faces of IL-6 in the tumor microenvironment

(2014) Daniel T. Fisher et al.   SEMINARS IN IMMUNOLOGY

Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion

(2014) R. Lock et al.   Cancer Discovery

Phospholipase C-related catalytically inactive protein (PRIP) controls KIF5B-mediated insulin secretion

(2014) S. Asano et al.   Biology Open

An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy

(2014) Mickaël Michaud et al.   OncoImmunology

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells

(2013) Geetanjali Kharmate et al.   Cancer Cell International

EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

(2013) Barry Jutten et al.   CELL CYCLE

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection

(2013) Kara L. Conway et al.   GASTROENTEROLOGY

Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

(2013) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity in unconventional protein secretion

(2013) Catherine Rabouille et al.   JOURNAL OF CELL SCIENCE

Gene Deletion of Gabarap Enhances Nlrp3 Inflammasome-Dependent Inflammatory Responses

(2013) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Linking γ-aminobutyric acid A receptor to epidermal growth factor receptor pathways activation in human prostate cancer

(2013) Weijuan Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor

(2013) Takehiro Torisu et al.   NATURE MEDICINE

A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells

(2013) Nicolas Pallet et al.   PROTEOMICS

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

(2013) Barry Jutten et al.   RADIOTHERAPY AND ONCOLOGY

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

(2013) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

Calreticulin surface exposure is abrogated in cells lacking, chaperone-mediated autophagy-essential gene, LAMP2A

(2013) A D Garg et al.   Cell Death & Disease

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Caspase activation regulates the extracellular export of autophagic vacuoles

(2012) Isabelle Sirois et al.   Autophagy

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

(2012) Luke R. G. Pike et al.   BIOCHEMICAL JOURNAL

Mechanisms of Autophagosome Biogenesis

(2012) David C. Rubinsztein et al.   CURRENT BIOLOGY

Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)-dependent Oligomerization of Fibroblast Growth Factor 2 (FGF2) Triggers the Formation of a Lipidic Membrane Pore Implicated in Unconventional Secretion

(2012) Julia P. Steringer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity

(2012) Koutaro Ishibashi et al.   MOLECULAR BIOLOGY OF THE CELL

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

(2012) Natalia von Muhlinen et al.   MOLECULAR CELL

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1

(2012) J R van Beijnum et al.   ONCOGENE

GABA stimulates human hepatocellular carcinoma growth through overexpressed GABAA receptor theta subunit

(2012) Yue-Hui Li   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Effects of C-terminal Modifications of GEC1 Protein and γ-Aminobutyric Acid Type A (GABAA) Receptor-associated Protein (GABARAP), Two Microtubule-associated Proteins, on κ Opioid Receptor Expression

(2011) Chongguang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury

(2011) Ulka Sachdev et al.   JOURNAL OF VASCULAR SURGERY

Constitutive Aberrant Endogenous Interleukin-1 Facilitates Inflammation and Growth in Human Melanoma

(2011) Y. Qin et al.   MOLECULAR CANCER RESEARCH

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

GABAA receptor associated protein (GABARAP) modulates TRPV1 expression and channel function and desensitization

(2010) S. Laínez et al.   FASEB JOURNAL

Regulation of autophagy by phosphatidylinositol 3-phosphate

(2010) Chloe Burman et al.   FEBS LETTERS

Unconventional secretion of Acb1 is mediated by autophagosomes

(2010) Juan M. Duran et al.   JOURNAL OF CELL BIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Selectins promote tumor metastasis

(2010) Heinz Läubli et al.   SEMINARS IN CANCER BIOLOGY

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease

(2009) Ken Cadwell et al.   Autophagy

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

(2009) Abhishek D. Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas

(2009) Isabelle Ray-Coquard et al.   CANCER RESEARCH

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

(2009) R Kang et al.   CELL DEATH AND DIFFERENTIATION

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells

(2009) T. Takenouchi et al.   JOURNAL OF IMMUNOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

(2009) Jan Theys et al.   RADIOTHERAPY AND ONCOLOGY

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

(2009) Kasper M.A. Rouschop et al.   RADIOTHERAPY AND ONCOLOGY

C-terminal processing of GABARAP is not required for trafficking of the angiotensin II type 1A receptor

(2009) Jawed Alam et al.   REGULATORY PEPTIDES

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

(2008) J Thorburn et al.   CELL DEATH AND DIFFERENTIATION

The Trafficking Protein GABARAP Binds to and Enhances Plasma Membrane Expression and Function of the Angiotensin II Type 1 Receptor

(2008) Julia L. Cook et al.   CIRCULATION RESEARCH

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition

(2008) Tija C. Jacob et al.   NATURE REVIEWS NEUROSCIENCE

Gamma-aminobutyric acid promotes human hepatocellular carcinoma growth through overexpressed gamma-aminobutyric acid A receptor α3 subunit

(2008) Yan Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY