Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma

(2015) Sheng Han et al.   BMC CANCER

Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastoma

(2015) E T Wong et al.   BRITISH JOURNAL OF CANCER

Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

(2015) Elias J. Sayour et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin

(2015) A. M. Dudek-Peri  et al.   CANCER RESEARCH

Dendritic Cell–Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma

(2015) Mahua Dey et al.   JOURNAL OF IMMUNOLOGY

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

(2015) Tien-Jen Lin et al.   Molecular Cancer

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Regulatory T cells are not a strong predictor of survival for patients with glioblastoma

(2015) A. A. Thomas et al.   NEURO-ONCOLOGY

Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies

(2015) Gautier Stoll et al.   Oncotarget

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

(2015) Abhishek D. Garg et al.   Oncotarget

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

PROGgeneV2: enhancements on the existing database

(2015) Chirayu Pankaj Goswami et al.   BMC CANCER

Predicting the “usefulness” of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European survey

(2014) Walter Stummer et al.   ACTA NEUROCHIRURGICA

Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma

(2014) S Han et al.   BRITISH JOURNAL OF CANCER

Active dendritic cell immunotherapy for glioblastoma: Current status and challenges

(2014) Stavros Polyzoidis et al.   BRITISH JOURNAL OF NEUROSURGERY

Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate-pulsed dendritic cells

(2014) Matthias Eyrich et al.   CYTOTHERAPY

Newcastle disease virotherapy induces long-term survival and tumor-specific immune memory in orthotopic glioma through the induction of immunogenic cell death

(2014) Carolien A. Koks et al.   INTERNATIONAL JOURNAL OF CANCER

Dendritic cell vaccination combined with temozolomide retreatment: results of a phase I trial in patients with recurrent glioblastoma multiforme

(2014) Martin K. Hunn et al.   JOURNAL OF NEURO-ONCOLOGY

Immunocompetent murine models for the study of glioblastoma immunotherapy

(2014) Taemin Oh et al.   Journal of Translational Medicine

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

Targeting adaptive glioblastoma: an overview of proliferation and invasion

(2014) Q. Xie et al.   NEURO-ONCOLOGY

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

(2014) Anna Sophie Berghoff et al.   NEURO-ONCOLOGY

Clinical Efficacy of Tumor Antigen-Pulsed DC Treatment for High-Grade Glioma Patients: Evidence from a Meta-Analysis

(2014) Jun-Xia Cao et al.   PLoS One

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

(2014) H Maes et al.   Cell Death & Disease

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Danger signalling during cancer cell death: origins, plasticity and regulation

(2013) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer

(2013) Helen Angell et al.   CURRENT OPINION IN IMMUNOLOGY

Foxp3+regulatory T cells are activated in spite of B7-CD28 and CD40-CD40L blockade

(2013) Isabel Vogel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

Analysis of CD137L and IL-17 Expression in Tumor Tissue as Prognostic Indicators for Gliblastoma

(2013) Xiangli Cui et al.   International Journal of Biological Sciences

Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity

(2013) Tina Verschuere et al.   INTERNATIONAL JOURNAL OF CANCER

The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma

(2013) Qi Yue et al.   JOURNAL OF NEURO-ONCOLOGY

Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level

(2013) Justyna Kmiecik et al.   JOURNAL OF NEUROIMMUNOLOGY

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Immune Heterogeneity of Glioblastoma Subtypes: Extrapolation from the Cancer Genome Atlas

(2013) T. Doucette et al.   Cancer Immunology Research

Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer Immunity

(2013) Aleksandra M. Dudek et al.   Frontiers in Immunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine

(2012) Hui-Ming Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy

(2012) Sadhak Sengupta et al.   Clinical & Developmental Immunology

Hypericin for visualization of high grade gliomas: First clinical experience

(2012) R. Ritz et al.   EJSO

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Epigenetic biomarkers of T-cells in human glioma

(2012) John K. Wiencke et al.   Epigenetics

MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction

(2012) N. Warner et al.   JOURNAL OF IMMUNOLOGY

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

(2012) Metamia Ciampricotti et al.   NATURE MEDICINE

Monitoring of Regulatory T Cell Frequencies and Expression of CTLA-4 on T Cells, before and after DC Vaccination, Can Predict Survival in GBM Patients

(2012) Brendan Fong et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Tumour-infiltrating T-cell subpopulations in glioblastomas

(2011) Young-Hee Kim et al.   BRITISH JOURNAL OF NEUROSURGERY

Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF- 

(2011) J. Lohr et al.   CLINICAL CANCER RESEARCH

Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide

(2011) Stuart A. Grossman et al.   CLINICAL CANCER RESEARCH

Impact of tumour volume on the potential efficacy of therapeutic vaccines

(2011) J. L. Gulley et al.   Current Oncology

Immune Response in Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Intranodal Autologous Tumor Lysate-dendritic Cell Vaccination After Radiation Chemotherapy

(2011) Camilo E. Fadul et al.   JOURNAL OF IMMUNOTHERAPY

NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy

(2010) Isabelle Coupienne et al.   BIOCHEMICAL PHARMACOLOGY

Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice

(2010) Rupal Ramakrishnan et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival

(2010) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Prognostic significance and mechanism of Treg infiltration in human brain tumors

(2010) Joannes F.M. Jacobs et al.   JOURNAL OF NEUROIMMUNOLOGY

A phase II placebo-controlled study of photodynamic therapy with topical hypericin and visible light irradiation in the treatment of cutaneous T-cell lymphoma and psoriasis

(2010) Alain H. Rook et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Dendritic Cell Therapy of High-Grade Gliomas

(2009) Stefaan Van Gool et al.   BRAIN PATHOLOGY

Immunological Factors Relating to the Antitumor Effect of Temozolomide Chemoimmunotherapy in a Murine Glioma Model

(2009) T.-G. Kim et al.   Clinical and Vaccine Immunology

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma

(2009) Wim Maes et al.   NEURO-ONCOLOGY

Incidence and Prognostic Impact of FoxP3+ Regulatory T Cells in Human Gliomas

(2008) A. B. Heimberger et al.   CLINICAL CANCER RESEARCH

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Photodynamic Therapy of Nonmelanoma Skin Cancer with Topical Hypericum perforatum Extract—A Pilot Study

(2008) Denisa Kacerovská et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: Case study

(2007) Amy B. Heimberger et al.   NEURO-ONCOLOGY