Hippo pathway and protection of genome stability in response to DNA damage

Clinical utility of RASSF1A methylation in human malignancies

(2015) A M Grawenda et al.   BRITISH JOURNAL OF CANCER

Safeguarding genome stability: RASSF1A tumor suppressor regulates BRCA2 at stalled forks

(2015) Dafni Eleftheria Pefani et al.   CELL CYCLE

The RASSF1A Tumor Suppressor Regulates XPA-Mediated DNA Repair

(2014) Howard Donninger et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

(2014) David Romano et al.   NATURE CELL BIOLOGY

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

(2014) Dafni-Eleftheria Pefani et al.   NATURE CELL BIOLOGY

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

(2014) Tian Yu et al.   Protein & Cell

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Mitotic Arrest by Tumor Suppressor RASSF1A Is Regulated via CHK1 Phosphorylation

(2013) Lingyan Jiang et al.   MOLECULAR CANCER RESEARCH

The Tumor Suppressor Gene, RASSF1A, Is Essential for Protection against Inflammation -Induced Injury

(2013) Marilyn Gordon et al.   PLoS One

Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome

(2012) Jia Xu et al.   BMC CANCER

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

(2012) S. Ying et al.   CANCER RESEARCH

A RASSF1A Polymorphism Restricts p53/p73 Activation and Associates with Poor Survival and Accelerated Age of Onset of Soft Tissue Sarcoma

(2012) K. S. Yee et al.   CANCER RESEARCH

Loss of Rassf1a Synergizes with Deregulated Runx2 Signaling in Tumorigenesis

(2012) L. van der Weyden et al.   CANCER RESEARCH

Epithelial cell polarity: what flies can teach us about cancer

(2012) Daniel T. Bergstralh et al.   Essays in Biochemistry

LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression

(2012) Tatsuyuki Chiyoda et al.   JOURNAL OF CELL BIOLOGY

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

(2012) Miki Nishio et al.   JOURNAL OF CLINICAL INVESTIGATION

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

MST1 Promotes Apoptosis through Regulating Sirt1-dependent p53 Deacetylation

(2011) Fang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions

(2011) Howard Donninger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tumor Suppressor RASSF1A Prevents Dephosphorylation of the Mammalian STE20-like Kinases MST1 and MST2

(2011) Cai Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinating developmental signaling: novel roles for the Hippo pathway

(2011) Xaralabos Varelas et al.   TRENDS IN CELL BIOLOGY

Cracking the death code: apoptosis-related histone modifications

(2010) J Füllgrabe et al.   CELL DEATH AND DIFFERENTIATION

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

(2010) Jianzhong Yu et al.   DEVELOPMENTAL CELL

RASSF1A polymorphism in familial breast cancer

(2010) J. Bergqvist et al.   Familial Cancer

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1

(2010) Y. Aylon et al.   GENES & DEVELOPMENT

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

MST1 Promotes Apoptosis through Phosphorylation of Histone H2AX

(2010) Weihong Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage

(2010) N. Okada et al.   JOURNAL OF CELL SCIENCE

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

(2010) Wei Fan et al.   MOLECULAR CELL

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

(2010) Paulo S. Ribeiro et al.   MOLECULAR CELL

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy

(2010) S Tommasi et al.   ONCOGENE

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

ATM Regulates a RASSF1A-Dependent DNA Damage Response

(2009) Garth Hamilton et al.   CURRENT BIOLOGY

Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

(2009) Y Aylon et al.   ONCOGENE

RASSF1A Polymorphism A133S Is Associated with Early Onset Breast Cancer in BRCA1/2 Mutation Carriers

(2008) B. Gao et al.   CANCER RESEARCH

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the Drosophila Hippo Pathway

(2008) J. Zhang et al.   CANCER RESEARCH

MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

(2008) Maria Praskova et al.   CURRENT BIOLOGY

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2–DAXX–HAUSP complex

(2008) Min Sup Song et al.   EMBO JOURNAL

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Loss of Rassf1a cooperates with Apc Min to accelerate intestinal tumourigenesis

(2008) L van der Weyden et al.   ONCOGENE