标题
The hedgehog pathway in triple-negative breast cancer
作者
关键词
-
出版物
Cancer Medicine
Volume 5, Issue 10, Pages 2989-3006
出版商
Wiley
发表日期
2016-08-19
DOI
10.1002/cam4.833
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508)
- (2016) Chandra P. Belani et al. CANCER
- Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology
- (2016) Paul S Weisman et al. MODERN PATHOLOGY
- Cooperatively transcriptional and epigenetic regulation of sonic hedgehog overexpression drives malignant potential of breast cancer
- (2015) Zhao-Heng Duan et al. CANCER SCIENCE
- Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032
- (2015) Giles W. Robinson et al. JOURNAL OF CLINICAL ONCOLOGY
- Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity
- (2015) R. C. D'Angelo et al. MOLECULAR CANCER THERAPEUTICS
- Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma
- (2015) Ulrike Graab et al. Oncotarget
- Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells
- (2015) Maria Peiris-Pagès et al. Oncotarget
- FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
- (2015) Bingchen Han et al. Cell Reports
- Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding
- (2015) Akwasi Agyeman et al. Oncotarget
- A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance
- (2014) Z. Liu et al. BLOOD
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
- (2014) Bin Li et al. CANCER RESEARCH
- Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer
- (2014) X. Li et al. CLINICAL CANCER RESEARCH
- Phase I Dose-Escalation Trial of the Oral Investigational Hedgehog Signaling Pathway Inhibitor TAK-441 in Patients with Advanced Solid Tumors
- (2014) J. Goldman et al. CLINICAL CANCER RESEARCH
- A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors
- (2014) J. Rodon et al. CLINICAL CANCER RESEARCH
- Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
- (2014) E. J. Kim et al. CLINICAL CANCER RESEARCH
- Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland
- (2014) Nadia Okolowsky et al. DEVELOPMENTAL BIOLOGY
- Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
- (2014) P. Infante et al. EMBO JOURNAL
- The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers
- (2014) Jun Long et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Distinct Effects of themesenchymal dysplasiaGene Variant of Murine Patched-1 Protein on Canonical and Non-canonical Hedgehog Signaling Pathways
- (2014) Malcolm C. Harvey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas
- (2014) Dongsheng Yue et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Sonic hedgehog–Gli1 signals promote epithelial–mesenchymal transition in ovarian cancer by mediating PI3K/AKT pathway
- (2014) Zhang Ke et al. MEDICAL ONCOLOGY
- Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation
- (2014) Ying Sun et al. Molecular Cancer
- Taxane-induced hedgehog signaling is linked to expansion of breast cancer stem-like populations after chemotherapy
- (2014) Jennifer Sims-Mourtada et al. MOLECULAR CARCINOGENESIS
- Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
- (2014) Yujie Tang et al. NATURE MEDICINE
- Stromal response to Hedgehog signaling restrains pancreatic cancer progression
- (2014) J. J. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gli-1 is crucial for hypoxia-induced epithelial-mesenchymal transition and invasion of breast cancer
- (2014) Jianjun Lei et al. TUMOR BIOLOGY
- Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial–mesenchymal transition in prostate cancer
- (2014) Fukashi Yamamichi et al. Scandinavian Journal of Urology
- Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour
- (2013) Zeinab Elsawaf et al. BREAST
- Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
- (2013) Y Yu et al. BRITISH JOURNAL OF CANCER
- FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer
- (2013) Chao Yang et al. CANCER LETTERS
- FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer
- (2013) B. G. Hollier et al. CANCER RESEARCH
- Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes
- (2013) H. Masuda et al. CLINICAL CANCER RESEARCH
- GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
- (2013) Hira Lal Goel et al. EMBO Molecular Medicine
- Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition
- (2013) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Patterns of Recurrence and Outcome According to Breast Cancer Subtypes in Lymph Node–Negative Disease: Results From International Breast Cancer Study Group Trials VIII and IX
- (2013) Otto Metzger-Filho et al. JOURNAL OF CLINICAL ONCOLOGY
- Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma
- (2013) Nataliya Razumilava et al. JOURNAL OF HEPATOLOGY
- Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
- (2013) Jianjun Lei et al. Molecular Cancer
- Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities
- (2013) Mariella Gruber Filbin et al. NATURE MEDICINE
- Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer
- (2013) E. S. Antonarakis et al. ONCOLOGIST
- Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy
- (2013) Sonia Coni et al. PLoS One
- LKB1 Inhibits Breast Cancer Partially through Repressing the Hedgehog Signaling Pathway
- (2013) Zhigang Zhuang et al. PLoS One
- Emerging targeted therapies in triple-negative breast cancer
- (2012) J. Crown et al. ANNALS OF ONCOLOGY
- Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma
- (2012) I. S. Chan et al. CANCER RESEARCH
- Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
- (2012) B. Ramaswamy et al. CANCER RESEARCH
- A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer
- (2012) J. Berlin et al. CLINICAL CANCER RESEARCH
- Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1
- (2012) Hong Chang et al. DEVELOPMENTAL BIOLOGY
- Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland
- (2012) Elena García-Zaragoza et al. DEVELOPMENTAL BIOLOGY
- Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
- (2012) Markus Eberl et al. EMBO Molecular Medicine
- Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin
- (2012) Eri Makinodan et al. EXPERIMENTAL DERMATOLOGY
- Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers
- (2012) Xiang Jiao et al. GENES CHROMOSOMES & CANCER
- Impact of Triple-Negative Breast Cancer Phenotype on Prognosis in Patients with Stage I Breast Cancer
- (2012) Jeong Eun Kim et al. Journal of Breast Cancer
- Unknown
- (2012) Rikke Leth-Larsen et al. MOLECULAR MEDICINE
- Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
- (2012) Aleksandar Sekulic et al. NEW ENGLAND JOURNAL OF MEDICINE
- Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s)
- (2012) K C Scribner et al. ONCOGENE
- FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling
- (2012) J Wang et al. ONCOGENE
- Epithelial-Stromal Interactions in Human Breast Cancer: Effects on Adhesion, Plasma Membrane Fluidity and Migration Speed and Directness
- (2012) Cristiana Angelucci et al. PLoS One
- ErbB receptor tyrosine kinase/NF- B signaling controls mammosphere formation in human breast cancer
- (2012) K. Hinohara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Primary cilia and graded Sonic Hedgehog signaling
- (2012) Noriaki Sasai et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration
- (2011) Z I Thomas et al. BRITISH JOURNAL OF CANCER
- Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity
- (2011) S. Singh et al. CANCER RESEARCH
- Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer
- (2011) S. A. O'Toole et al. CANCER RESEARCH
- Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment
- (2011) E. Heller et al. CANCER RESEARCH
- Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
- (2011) Christina Scheel et al. CELL
- Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines
- (2011) Yeon-Jin Kwon et al. CLINICAL & EXPERIMENTAL METASTASIS
- Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened
- (2011) Adriana P. Visbal et al. DEVELOPMENTAL BIOLOGY
- CD44+/CD24−/low cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome
- (2011) Michael O. Idowu et al. HUMAN PATHOLOGY
- Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration
- (2011) Ariel H. Polizio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
- (2011) Brian D. Lehmann et al. JOURNAL OF CLINICAL INVESTIGATION
- Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells
- (2011) X Cao et al. ONCOGENE
- Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61
- (2011) L G Harris et al. ONCOGENE
- Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
- (2010) James Kim et al. CANCER CELL
- TGF- Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling
- (2010) R. W. Johnson et al. CANCER RESEARCH
- Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
- (2010) Pilar Chinchilla et al. CELL CYCLE
- Hedgehog Signaling Induced by Breast Cancer Cells Promotes Osteoclastogenesis and Osteolysis
- (2010) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
- (2010) Elspeth M. Beauchamp et al. JOURNAL OF CLINICAL INVESTIGATION
- Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
- (2010) Gianluca Canettieri et al. NATURE CELL BIOLOGY
- Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
- (2010) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
- (2010) J. H. Taube et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals
- (2010) B. Stecca et al. Journal of Molecular Cell Biology
- Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer
- (2009) H Nalwoga et al. BRITISH JOURNAL OF CANCER
- Development of Mammary Tumors by Conditional Expression of GLI1
- (2009) M. Fiaschi et al. CANCER RESEARCH
- Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers
- (2009) T. Tanei et al. CLINICAL CANCER RESEARCH
- Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer
- (2009) E. Charafe-Jauffret et al. CLINICAL CANCER RESEARCH
- Cloning of the HumanGLI2Promoter
- (2009) Sylviane Dennler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Hedgehog Pathway Transcription Factor GLI1 Promotes Malignant Behavior of Cancer Cells by Up-regulating Osteopontin
- (2009) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer
- (2009) Motoko Seto et al. MOLECULAR CARCINOGENESIS
- The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex
- (2009) Frédéric Mille et al. NATURE CELL BIOLOGY
- Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
- (2009) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
- (2009) J. M. Hyman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Runx2 Transcriptional Activation of Indian Hedgehog and a Downstream Bone Metastatic Pathway in Breast Cancer Cells
- (2008) J. Pratap et al. CANCER RESEARCH
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling
- (2008) Markku Varjosalo et al. CELL
- Naturally Occurring Small-Molecule Inhibitors of Hedgehog/GLI-Mediated Transcription
- (2008) Takahiro Hosoya et al. CHEMBIOCHEM
- Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
- (2008) E. Dessaud et al. DEVELOPMENT
- High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability
- (2008) Alysha K. Croker et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
- (2008) Anne-Pierre Morel et al. PLoS One
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