Key mechanisms involved in ionizing radiation-induced systemic effects. A current review

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

(2015) Benjamin Frey et al.   CANCER LETTERS

Non-targeted effects induced by ionizing radiation: Mechanisms and potential impact on radiation induced health effects

(2015) William F. Morgan et al.   CANCER LETTERS

HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas

(2015) Anne Ernst et al.   CANCER LETTERS

Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology

(2015) Vasiliki I. Hatzi et al.   CANCER LETTERS

The many interactions between the innate immune system and the response to radiation

(2015) Serge M. Candéias et al.   CANCER LETTERS

Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects

(2015) Carl N. Sprung et al.   CANCER LETTERS

The Nuclear Factor κB pathway: A link to the immune system in the radiation response

(2015) Christine E. Hellweg   CANCER LETTERS

The role of oxidative DNA damage in radiation induced bystander effect

(2015) Sophia Havaki et al.   CANCER LETTERS

Emerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approaches

(2015) Alexandros G. Georgakilas et al.   CANCER LETTERS

The inflammasome accelerates radiation-induced lung inflammation and fibrosis in mice

(2015) Sung-Hwa Sohn et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Naringin inhibits gamma radiation-induced oxidative DNA damage and inflammation, by modulating p53 and NF-κB signaling pathways in murine splenocytes

(2015) K. Manna et al.   FREE RADICAL RESEARCH

Growth differentiation factor 15 as a radiation-induced marker in oral carcinoma increasing radiation resistance

(2015) Eik Schiegnitz et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

The non-targeted effects of radiation are perpetuated by exosomes

(2015) Ammar Al-Mayah et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Growth Differentiation Factor-15 (GDF-15) is a potential marker of radiation response and radiation sensitivity

(2015) Nikolett Sándor et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells

(2015) Rafael Carretero et al.   NATURE IMMUNOLOGY

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where

(2015) Ioannis S. Pateras et al.   PHARMACOLOGY & THERAPEUTICS

Non-targeted effects of radiation exposure: recent advances and implications: Figure 1.

(2015) M. A. Kadhim et al.   RADIATION PROTECTION DOSIMETRY

Mechanisms of the induction of apoptosis mediated by radiation-induced cytokine release

(2015) G. Babini et al.   RADIATION PROTECTION DOSIMETRY

Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner

(2015) N Werthmöller et al.   Cell Death & Disease

The role of TGF-β1–miR-21–ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells

(2014) Y Jiang et al.   BRITISH JOURNAL OF CANCER

Head and neck cancer relapse after chemoradiotherapy correlates with CD163+ macrophages in primary tumour and CD11b+ myeloid cells in recurrences

(2014) P Balermpas et al.   BRITISH JOURNAL OF CANCER

Radiation-Induced Modulation of Costimulatory and Coinhibitory T-Cell Signaling Molecules on Human Prostate Carcinoma Cells Promotes Productive Antitumor Immune Interactions

(2014) Michael B. Bernstein et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages

(2014) Julie M. Lowe et al.   CANCER RESEARCH

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Induction of bystander effects by UVA, UVB, and UVC radiation in human fibroblasts and the implication of reactive oxygen species

(2014) Maria Widel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy

(2014) Udo S Gaipl et al.   Immunotherapy

High hydrostatic pressure induces immunogenic cell death in human tumor cells

(2014) Jitka Fucikova et al.   INTERNATIONAL JOURNAL OF CANCER

Intensity modulated radiotherapy induces pro-inflammatory and pro-survival responses in prostate cancer patients

(2014) HOUSSEIN EL-SAGHIRE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Combinations of Radiation Therapy and Immunotherapy for Melanoma: A Review of Clinical Outcomes

(2014) Christopher A. Barker et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Small oral squamous cell carcinomas with nodal lymphogenic metastasis show increased infiltration of M2 polarized macrophages – An immunohistochemical analysis

(2014) Manuel Weber et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells

(2014) Veit M. Stoecklein et al.   JOURNAL OF IMMUNOLOGY

Reactive Oxygen Species– and DNA Damage Response–Dependent NK Cell Activating Ligand Upregulation Occurs at Transcriptional Levels and Requires the Transcriptional Factor E2F1

(2014) Alessandra Soriani et al.   JOURNAL OF IMMUNOLOGY

Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells

(2014) Lorenz Kulzer et al.   Journal of Immunotoxicology

Differential Expression of Stress and Immune Response Pathway Transcripts and miRNAs in Normal Human Endothelial Cells Subjected to Fractionated or Single-Dose Radiation

(2014) Sanjeewani T. Palayoor et al.   MOLECULAR CANCER RESEARCH

Low Doses of Gamma-Irradiation Induce an Early Bystander Effect in Zebrafish Cells Which Is Sufficient to Radioprotect Cells

(2014) Sandrine Pereira et al.   PLoS One

Immunological aspects of radiotherapy

(2014) Heike Scheithauer et al.   Radiation Oncology

Defining Molecular Signature of Pro-Immunogenic Radiotherapy Targets in Human Prostate Cancer Cells

(2014) Molykutty J. Aryankalayil et al.   RADIATION RESEARCH

Irradiated U937 Cells Trigger Inflammatory Bystander Responses in Human Umbilical Vein Endothelial Cells through the p38 Pathway

(2014) Linlin Xiao et al.   RADIATION RESEARCH

Irradiation of existing atherosclerotic lesions increased inflammation by favoring pro-inflammatory macrophages

(2014) Karen Gabriels et al.   RADIOTHERAPY AND ONCOLOGY

Gene expression responses in human lung fibroblasts exposed to alpha particle radiation

(2014) Vinita Chauhan et al.   TOXICOLOGY IN VITRO

Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy

(2014) Irena Adkins et al.   OncoImmunology

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy

(2013) Matthew D. Vesely et al.   Annals of the New York Academy of Sciences

Radiation-induced non-targeted response in vivo: role of the TGFβ-TGFBR1-COX-2 signalling pathway

(2013) Y Chai et al.   BRITISH JOURNAL OF CANCER

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Antitumor immune responses induced by ionizing irradiation and further immune stimulation

(2013) Benjamin Frey et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Low-Dose γ-Irradiation Affects the Survival of Exposed Daphnia and their Offspring

(2013) Elena I. Sarapultseva et al.   Dose-Response

Bystander Effect between Zebrafish Embryos in Vivo Induced by High-Dose X-rays

(2013) V. W. Y. Choi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Low doses of ionizing radiation induce immune-stimulatory responses in isolated human primary monocytes

(2013) HOUSSEIN EL-SAGHIRE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Gene set enrichment analysis highlights different gene expression profiles in whole blood samples X-irradiated with low and high doses

(2013) Houssein El-Saghire et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Oncogenic Radiation Abscopal Effects In Vivo: Interrogating Mouse Skin

(2013) Mariateresa Mancuso et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

(2013) Cherilyn M. Sirois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR1/2 Ligand-Stimulated Mouse Liver Endothelial Cells Secrete IL-12 and Trigger CD8+ T Cell Immunity In Vitro

(2013) J. Liu et al.   JOURNAL OF IMMUNOLOGY

Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation

(2013) Moritz Ries et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Widespread Decreased Expression of Immune Function Genes in Human Peripheral Blood Following Radiation Exposure

(2013) Sunirmal Paul et al.   RADIATION RESEARCH

Low-Dose Gamma Irradiation Enhances Superoxide Anion Production by Nonirradiated Cells Through TGF-β1-Dependent Bystander Signaling

(2013) Jennifer Temme et al.   RADIATION RESEARCH

Radiation-Induced Bystander Signaling from Somatic Cells to Germ Cells inCaenorhabditis elegans

(2013) Xiaoying Guo et al.   RADIATION RESEARCH

Issues in Low Dose Radiation Biology: The Controversy Continues. A Perspective

(2013) William F. Morgan et al.   RADIATION RESEARCH

Radio-induced apoptosis of peripheral blood CD8 T lymphocytes is a novel prognostic factor for survival in cervical carcinoma patients

(2013) R. Ordoñez et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Lipopolysaccharide Appears to Activate Human Endometrial Endothelial Cells Through TLR-4-Dependent and TLR-4-Independent Mechanisms

(2012) Graciela Krikun et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

An acute negative bystander effect of  -irradiated recipients on transplanted hematopoietic stem cells

(2012) H. Shen et al.   BLOOD

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

Induction of Abscopal Anti-Tumor Immunity and Immunogenic Tumor Cell Death by Ionizing Irradiation - Implications for Cancer Therapies

(2012) B. Frey et al.   CURRENT MEDICINAL CHEMISTRY

Interactions between the tumor suppressor p53 and immune responses

(2012) Daniel Menendez et al.   CURRENT OPINION IN ONCOLOGY

Hormetic Effect Induced by Alpha-Particle-Induced Stress Communicated In Vivo between Zebrafish Embryos

(2012) V. W. Y. Choi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Investigation of the mechanisms underpinning IL-6 cytokine release in bystander responses: The roles of radiation dose, radiation quality and specific ROS/RNS scavengers

(2012) Luca G Mariotti et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Low dose ionising radiation leads to a NF-κB dependent decreased secretion of active IL-1β by activated macrophages with a discontinuous dose-dependency

(2012) Barbara Lödermann et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

MyD88 provides a protective role in long-term radiation-induced lung injury

(2012) Willie J. Brickey et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Combined treatment of human colorectal tumor cell lines with chemotherapeutic agents and ionizing irradiation canin vitroinduce tumor cell death forms with immunogenic potential

(2012) Benjamin Frey et al.   Journal of Immunotoxicology

Non-targeted effects of ionising radiation—Implications for low dose risk

(2012) Munira Kadhim et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

(2012) Jamie J Bernard et al.   NATURE MEDICINE

Phosphorylation of p65(RelA) on Ser547 by ATM Represses NF-κB-Dependent Transcription of Specific Genes after Genotoxic Stress

(2012) Hélène Sabatel et al.   PLoS One

Cytokines in Radiobiological Responses: A Review

(2012) Dörthe Schaue et al.   RADIATION RESEARCH

Bystander-Type Effects Mediated by Long-Lived Inflammatory Signaling in Irradiated Bone Marrow

(2012) Shubhra Rastogi et al.   RADIATION RESEARCH

The Tipping Point for Combination Therapy: Cancer Vaccines With Radiation, Chemotherapy, or Targeted Small Molecule Inhibitors

(2012) James W. Hodge et al.   SEMINARS IN ONCOLOGY

The danger theory in view of the injury hypothesis: 20 years later

(2012) Walter G. Land et al.   Frontiers in Immunology

Dying cell clearance and its impact on the outcome of tumor radiotherapy

(2012) Kirsten Lauber et al.   Frontiers in Oncology

Long-lived Inflammatory Signaling in Irradiated Bone Marrow Is Genome Dependent

(2011) S. A. Lorimore et al.   CANCER RESEARCH

Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults

(2011) Lori B. Daniels et al.   CIRCULATION

Differential expression of immune-associated cancer regulatory genes in low- versus high-dose-rate irradiated AKR/J mice

(2011) Suk Chul Shin et al.   GENOMICS

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Repeated exposure of human fibroblasts to ionizing radiation reveals an adaptive response that is not mediated by interleukin-6 or TGF-β

(2011) Birger Dieriks et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Low dose radiation response curves, networks and pathways in human lymphoblastoid cells exposed from 1 to 10cGy of acute gamma radiation

(2011) A.J. Wyrobek et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Role of connexin43 and ATP in long-range bystander radiation damage and oncogenesis in vivo

(2011) M Mancuso et al.   ONCOGENE

Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages

(2011) Petra Schildkopf et al.   RADIOTHERAPY AND ONCOLOGY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

The Toll-Like Receptor Gene Family Is Integrated into Human DNA Damage and p53 Networks

(2011) Daniel Menendez et al.   PLoS Genetics

Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality

(2010) Fredrik E. Wiklund et al.   AGING CELL

Ex vivo- and in vivo-induced dead tumor cells as modulators of antitumor responses

(2010) Eva-Maria Weiss et al.   Annals of the New York Academy of Sciences

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

How do Tumors Actively Escape from Host Immunosurveillance?

(2010) Jacek R. Wilczyński et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Evidence of an Adaptive Response Targeting DNA Nonhomologous End Joining and Its Transmission to Bystander Cells

(2010) H. Klammer et al.   CANCER RESEARCH

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways

(2010) Olga Kovalchuk et al.   CARCINOGENESIS

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Sequential expression of macrophage anti-microbial/inflammatory and wound healing markers following innate, alternative and classical activation

(2010) F. M. Menzies et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Radiation Induced Bystander effects in Mice given Low Doses of Radiation in vivo

(2010) Harleen Singh et al.   Dose-Response

Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma

(2010) K. Soucek et al.   HUMAN REPRODUCTION

Proteomics of the Radioresistant Phenotype in Head-and-Neck Cancer: Gp96 as a Novel Prediction Marker and Sensitizing Target for Radiotherapy

(2010) Ting-Yang Lin et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Genomic instability after targeted irradiation of human lymphocytes: Evidence for inter-individual differences under bystander conditions

(2010) Munira A. Kadhim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model

(2010) Igor Koturbash et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Investigation of Adaptive Responses in Bystander Cells in 3D Cultures Containing Tritium-Labeled and Unlabeled Normal Human Fibroblasts

(2010) Massimo Pinto et al.   RADIATION RESEARCH

The Induction of Bystander Mutagenic EffectsIn Vivoby Alpha-Particle Irradiation in WholeArabidopsis thalianaPlants

(2010) Fanghua Li et al.   RADIATION RESEARCH

Gene Expression Profiles in Mouse Liver after Long-Term Low-Dose-Rate Irradiation with Gamma Rays

(2010) Yoshihiko Uehara et al.   RADIATION RESEARCH

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease: Figure 1

(2009) Tomas Lindahl et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

γ-Irradiation induces P2X7 receptor-dependent ATP release from B16 melanoma cells

(2009) Yasuhiro Ohshima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK–RhoA signaling pathway

(2009) S Senapati et al.   ONCOGENE

Cytokine-induced memory-like natural killer cells

(2009) Megan A. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-particle-induced bystander effects between zebrafish embryos in vivo

(2009) E.H.W. Yum et al.   RADIATION MEASUREMENTS

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

(2009) James F Curtin et al.   PLOS MEDICINE

Chromosomal Instability in Unirradiated Hemaopoietic Cells Induced by Macrophages Exposed In vivo to Ionizing Radiation

(2008) S. A. Lorimore et al.   CANCER RESEARCH

Inflammation and Chronic Oxidative Stress in Radiation-Induced Late Normal Tissue Injury: Therapeutic Implications

(2008) Weiling Zhao et al.   CURRENT MEDICINAL CHEMISTRY

Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner

(2008) Yaroslav Ilnytskyy et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

In Vivo Bystander Effect: Cranial X-Irradiation Leads to Elevated DNA Damage, Altered Cellular Proliferation and Apoptosis, and Increased p53 Levels in Shielded Spleen

(2008) Igor Koturbash et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Formation of Clustered DNA Damage after High-LET Irradiation: A Review

(2008) Megumi HADA et al.   JOURNAL OF RADIATION RESEARCH

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum

(2008) M. Mancuso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bystander/Abscopal Effects Induced in Intact Arabidopsis Seeds by Low-Energy Heavy-Ion Radiation

(2008) Gen Yang et al.   RADIATION RESEARCH

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

(2008) Xiu R. Lowe et al.   RADIATION RESEARCH

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE