Article
Environmental Sciences
Qiang Luo, Shuqiong Tang, Xiaoping Xiao, You Wei, Bo Cheng, Yong Huang, Keyuan Zhong, Guiyou Tian, Huiqiang Lu
Summary: In this study, the toxicity of benomyl to zebrafish was evaluated, showing high toxicity and inducing oxidative stress and apoptosis. These findings provide important insights into the safe use of benomyl.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Shanghong Wang, Xue Han, Tingting Yu, Yulong Liu, Hongying Zhang, Huiling Mao, Chengyu Hu, Xiaowen Xu
Summary: Exposure to isoprocarb induces developmental toxicity, hindbrain defects, and impaired motor ability in zebrafish embryos. The expressions of genes involved in neurodevelopment signaling pathways are inhibited, and oxidative stress is induced, which may be the molecular basis of isoprocarb-induced neurotoxicity in zebrafish embryos.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Viktor Manuel Jooss, Jan Stephan Bolten, Joerg Huwyler, Daniel Ahmed
Summary: In vivo micromanipulation using ultrasound allows for precise manipulation of gas-filled microparticles in zebrafish embryos, offering potential therapeutic options.
Article
Biochemistry & Molecular Biology
Xue Han, Xiaowen Xu, Tingting Yu, Meifeng Li, Yulong Liu, Jingli Lai, Huiling Mao, Chengyu Hu, Shanghong Wang
Summary: Exposure to Diflubenzuron resulted in cardiac developmental damage in zebrafish embryos, increased apoptotic cells and promoted the expression of apoptosis-related genes, while inhibiting the expression of some heart-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Mingyue He, Xueting Li, Lidong Yu, Shuai Deng, Ning Gu, Li Li, Jianbo Jia, Bingsheng Li
Summary: Nano-ZnO exhibits excellent antibacterial properties but can cause hepatotoxicity leading to the development of fatty liver disease in zebrafish. Our study reveals that Nano-ZnO triggers oxidative and endoplasmic reticulum stress, promoting fatty acid synthesis and steatosis. Treatment with carbon dots alleviates the hepatotoxicity of Nano-ZnO.
Article
Environmental Sciences
Jinze Ma, Ping Jiang, Yong Huang, Chen Lu, Guiyou Tian, Xiaoping Xiao, Yunlong Meng, Xiaoqiang Xiong, Bo Cheng, Di Wang, Huiqiang Lu
Summary: The herbicide flumioxazin has been found to induce cardiac defects in vertebrates, possibly due to oxidative stress. This study investigated the underlying mechanisms and found that flumioxazin caused cardiac malformations and abnormal gene expression associated with cardiac development. It also led to increased oxidative stress and apoptosis in the zebrafish heart. The antioxidant astaxanthin reversed these effects and protected against flumioxazin-induced cardiotoxicity.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Environmental Sciences
Jinze Ma, Yong Huang, Yuyang Peng, Zhaopeng Xu, Ziqin Wang, Xiaobei Chen, Shuling Xie, Ping Jiang, Keyuan Zhong, Huiqiang Lu
Summary: The study showed that bifenazate exposure has significant toxicity to aquatic organisms, especially zebrafish. Exposure to bifenazate causes severe cardiac toxicity in zebrafish, which can be partially alleviated by the antioxidant astaxanthin, indicating oxidative stress as a key mechanism in bifenazate-induced cardiotoxicity.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Yong Huang, Ziqin Wang, Yuyang Peng, Rong Xu, Jiajie Yan, Cong Xiong, Jinze Ma, Keyuan Zhong, Huiqiang Lu
Summary: Carboxin exhibits developmental and cardiotoxicity in zebrafish embryos, causing structural changes in the heart and disruption of heart developmental gene expression. Additionally, Carboxin induces oxidative stress and accumulation of reactive oxygen species (ROS) in zebrafish embryos, leading to mitochondrial damage and decreased ATPase activities. Carboxin also inhibits myocardial cell proliferation and decreases the number of blood cells in the heart, resulting in embryo death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Meifeng Li, Tingting Yu, Jingli Lai, Xue Han, Jihuan Hu, Zeyuan Deng, Dongming Li, Zuocheng Ye, Shanghong Wang, Chengyu Hu, Xiaowen Xu
Summary: The study revealed that ethoprophos exposure can cause cardiac defects in zebrafish embryos, such as low heart rate, pericardium edema, and long SV-BA distance, while not affecting vascular development. This indicates that oxidative stress and inhibition of the wnt signaling pathway are the molecular mechanisms underlying ethoprophos-induced injury in zebrafish.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Yunlong Meng, Keyuan Zhong, Suping Chen, Yong Huang, You Wei, Juan Wu, Juan Liu, Zhaopeng Xu, Jing Guo, Fasheng Liu, Huiqiang Lu
Summary: The study revealed that exposure to Pendimethalin can reduce heart rate, survival rate, and body length of zebrafish embryos, causing various malformations and affecting antioxidant enzyme activity and the expression of genes related to cardiac development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Wenhua Yan, Tian Zhang, Shuaiting Li, Yunpeng Wang, Li Zhu, Yu Cao, Xiaofang Lai, Huizhe Huang
Summary: This study investigated the effects of areca nut alkaloids on zebrafish embryonic development and motor behavior. It was found that exposure to these alkaloids resulted in dose-dependent changes in zebrafish larvae, including increased malformation rate and decreased swimming activity. Additionally, oxidative stress and transcriptome analysis revealed potential mechanisms underlying these effects. These findings contribute to the risk assessment and early warning of areca nut alkaloid exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Xiaomei Chen, Jun Guo, Yong Huang, Zekun Li, Wei Yuan, Suwen Zeng, Hanyi Zhu, Yinliang Zhong, Weiying Lin, Huiqiang Lu, Jian Yang
Summary: This study evaluated the ecological impact of O-phenylphenol (OPP) using a zebrafish model, and found that OPP exposure leads to early disorder in craniofacial development and behavioral abnormalities in zebrafish. Furthermore, OPP exposure induces reactive oxygen species production, oxidative stress, and reduces the proliferation of cranial neural crest stem cells (NCCs). Astaxanthin (AST), an antioxidant, partially rescues OPP-induced craniofacial cartilage development abnormalities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Eric Gyimah, Xian Zhu, Ziqi Zhang, Mengyuan Guo, Hai Xu, John Kenneth Mensah, Xing Dong, Zhen Zhang, Godfred Nana Wireko Gyimah
Summary: The present study investigated the potential mechanisms in BPAF-induced neurotoxicity in zebrafish embryos. The results showed that BPAF could cause decreased locomotor activity, apoptosis, and oxidative stress response in zebrafish embryos, as well as significant alterations in dopamine-related genes and neurodevelopmental genes expression.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Polymer Science
Ana Teixeira, Marisa P. Sarria, Ines Pinto, Begona Espina, Andreia C. Gomes, Alberto C. P. Dias
Summary: Curcumin, a multivalent molecule with antioxidant, anti-inflammatory, and neuroprotective properties, has poor chemical stability and low oral bioavailability, limiting its application. This study developed PCL nanoparticles loaded with curcumin and evaluated their protective capacity against herbicide-induced oxidative damage.
Article
Biochemistry & Molecular Biology
Modi Kiran Piyushbhai, Ambika Binesh, S. A. Shanmugam, Kaliyamurthi Venkatachalam
Summary: This study found that even a low dose of inorganic arsenic compound can cause teratogenicity, behavioral abnormalities, altered enzyme activities, and the expression of proinflammatory cytokines in zebrafish embryos.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jiandong Zhou, Guoming Zhang, Carlin Chang, Oscar Hou In Chou, Sharen Lee, Keith Sai Kit Leung, Wing Tak Wong, Tong Liu, Abraham Ka Chung Wai, Shuk Han Cheng, Qingpeng Zhang, Gary Tse
Summary: This study compares the cardiovascular effects of metformin and sulphonylurea in patients with type 2 diabetes mellitus. The results show that sulphonylurea users have a higher risk of atrial fibrillation, stroke, cardiovascular mortality, and all-cause mortality compared to metformin users. Male patients and those over 65 years old with sulphonylurea use are at the highest risk.
ACTA DIABETOLOGICA
(2022)
Article
Oncology
Waleed Abdelbag Almahi, K. N. Yu, Fathelrahman Mohammed, Peizhong Kong, Wei Han
Summary: The principle of radiotherapy is to kill cancer cells while minimizing harm to non-cancer cells. Ferroptosis has been proposed as a new mechanism of radiation-induced cell death. This study demonstrated that Hemin, an iron overload agent, enhances reactive oxygen species (ROS) generation induced by ionizing radiation in lung cancer cells, leading to ferroptosis. Hemin also protected normal lung cells against radiation-induced cell death.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Guodong Chen, Peizhong Kong, Miaomiao Yang, Wanglai Hu, Kevin M. Prise, K. N. Yu, Shujun Cui, Feng Qin, Gang Meng, Waleed Abdelbagi Almahi, Lili Nie, Wei Han
Summary: GOLPH3 mediates radioresistance in lung adenocarcinoma (LUAD) by stabilizing EGFR, and targeted suppression of GOLPH3 could enhance the sensitivity of LUAD to radiation therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Biology
Mehrdad Shahmohammadi Beni, Kwan Ngok Yu, M. Rafiqul Islam, Hiroshi Watabe
Summary: The Monte Carlo method is a powerful tool for modeling nuclear radiation interaction with matter. In this study, a custom-made GUI bundled with a 3D OpenGL visualizer has been developed for the PHITS MC package. The program focuses on modeling proton induced positron emitting radioisotopes, which can be used for verifying proton ranges in proton therapy. The GUI program is user-friendly and distributed under an open-source license.
JOURNAL OF RADIATION RESEARCH
(2022)
Article
Chemistry, Physical
K. N. Yu
Summary: This paper reviews the role of radiation-induced rescue effect (RIRE) in radiation field size effect. It discusses the relationship between the biological effects of ionizing radiation and the size of the irradiated area. RIRE refers to the mitigation of detrimental effects in irradiated cells after receiving signals from non-irradiated bystander cells or from previously conditioned bystander cells. The paper provides a brief overview of RIRE, including its definition, classification, signalling pathways, and chemical messengers, and also reviews selected literature on radiation field size effects. It concludes with a discussion on the future research priorities and directions of RIRE in radiation field size effect.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Oncology
Wei Cao, Guodong Chen, Lijun Wu, K. N. Yu, Mingyu Sun, Miaomiao Yang, Yanyi Jiang, Yuan Jiang, Yuan Xu, Shengjie Peng, Wei Han
Summary: The study investigates radiation-induced pyroptosis and its implications for radiation therapy. It explores the factors involved, possible mechanisms, and the effect on antitumor immunity. The results show that radiation induces pyroptosis in GSDME high-expressing tumor cell lines. Combination therapy with chemotherapy drugs and radiation enhances pyroptosis occurrence. This study provides valuable insights for improving the efficacy of tumor radiation therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Multidisciplinary Sciences
Mehrdad Shahmohammadi Beni, Hiroshi Watabe, Wing Sum Kwan, M. Rafiqul Islam, Kwan Ngok Yu
Summary: In this study, an open-source GUI computer program called RadStat was developed for statistical analysis of counts measured by a GM counter. RadStat provides a quick and convenient way to perform data analysis and visualization, making it a useful tool for research and teaching in nuclear radiation physics.
Review
Cardiac & Cardiovascular Systems
Jiandong Zhou, Sharen Lee, Yingzhi Liu, Jeffrey Shi Kai Chan, Guoliang Li, Wing Tak Wong, Kamalan Jeevaratnam, Shuk Han Cheng, Tong Liu, Gary Tse, Qingpeng Zhang
Summary: We hypothesized that an interpretable gradient boosting machine (GBM) model considering comorbidities, P-wave and echocardiographic measurements, can better predict mortality and cerebrovascular events in mitral regurgitation (MR).
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Nuclear Science & Technology
Hiroshi Watabe, Kwan Ngok Yu, Nursel Safakatti, Mehrdad Shahmohammadi Beni
Summary: The Monte Carlo (MC) method is essential in nuclear radiation research, and we have developed an open-source GUI computer program for radiation transport and interaction modeling using the PHITS MC package in segmented slab phantoms. This program is useful for future users, especially those with less experience in the PHITS MC package.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Sharen Lee, Cheuk To Chung, Oscar Hou In Chou, Teddy Tai Loy Lee, Danny Radford, Kamalan Jeevaratnam, Wing Tak Wong, Shuk Han Cheng, Ngai Shing Mok, Tong Liu, Gary Tse
Summary: Understanding the utilization of healthcare resources and its associated costs is crucial for improving resource allocation, but little research has been conducted on this issue in the setting of Brugada syndrome (BrS). In this retrospective study of BrS patients in Hong Kong, the healthcare resource utilization for accident and emergency, inpatient, and specialist outpatient visits was analyzed over 19 years. The median annual costs were $110 for accident and emergency visits, $6812 for inpatient stays, and $557 for specialist outpatient visits.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Environmental Sciences
Kwan Ngok Yu, Hiroshi Watabe, Milena Zivkovic, Dragana Krstic, Dragoslav Nikezic, Kyeong Min Kim, Taiga Yamaya, Naoki Kawachi, Hiroki Tanaka, A. K. F. Haque, Mehrdad Shahmohammadi Beni
Summary: This paper introduces an open-source graphical user interface (GUI) computer program called DynamicMC, which can generate an ORNL phantom input script for the Monte Carlo N-Particle (MCNP) package. The program can simulate the relative dynamic movement of the radiation source with respect to the ORNL phantom, similar to the movement of source-to-target (i.e., human phantom) distance in a 3-dimensional radiation field. It simplifies the organ-based dosimetry of the human body and can be used as a teaching tool for nuclear radiation physics and its interaction with the human body.
Article
Chemistry, Physical
Milena Zivkovic, Mehrdad Shahmohammadi Beni, Peter K. N. Yu, Hiroshi Watabe, Dragana Krstic, Dragoslav Nikezic
Summary: The detrimental effects of 137Cs soil contamination on human health were investigated. A general decrease in 137Cs concentration in soil samples was observed in 2018, although variations were found at different locations. The study also showed no significant difference in estimated equivalent dose rate per unit activity of 137Cs between ICRP and ORNL phantom models. Two open-source computer programs were developed to provide users with an easy-to-use interface and portable tools to determine dosimetric quantities.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Marine & Freshwater Biology
Drew R. Peterson, Frauke Seemann, Miles T. Wan, Roy R. Ye, Lianguo Chen, Keng P. Lai, Peter Yu, Richard Y. C. Kong, Doris W. T. Au
Summary: Estrogenic endocrine disrupting chemicals (EEDC) can impact offspring in a transgenerational manner through modifications of the germline epigenome. Exposure to EE2 during parental gametogenesis and embryogenesis can induce transgenerational reproductive effects and phenotype persistence in unexposed offspring. EE2 exposure also leads to feminization and subsequent masculinization of directly exposed generations. While reproductive output is more sensitive in females, immune competence is not significantly affected. These findings highlight the potential transgenerational toxicity of EEDCs and the negative impact on fish population sustainability.
AQUATIC TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peizhong Kong, Miaomiao Yang, Ying Wang, K. N. Yu, Lijun Wu, Wei Han
Summary: Radiation-induced intestinal injury (RIII) is a common complication of radiotherapy, seriously affecting patients' quality of life. This study found that ferroptosis plays a critical role in RIII, with increased levels of lipid peroxidation markers. In vivo experiments demonstrated that the ferroptosis inhibitor improved the survival rate and alleviated intestinal fibrosis in mice. It was also found that arachidonic acid enhanced ferroptosis in cultured intestinal epithelial cells and aggravated RIII. Mechanistic studies revealed that the level of ACSL4 protein increased after irradiation, regulated by the STAT1/IRF1 axis, while AMPK activation triggered by AA negatively regulated radiation-induced ferroptosis.
Article
Engineering, Marine
Yi Yang, Tze W. Chow, Yi Q. Zhang, Peter K. N. Yu, Chi C. Ko, Rudolf S. S. Wu
Summary: Existing methods for monitoring radionuclides in aquatic environments are often impractical due to the need for frequent sampling and tedious analytical procedures. This study explored the feasibility of using 'Artificial Mussels' (AMs) as a new tool for radionuclide monitoring in marine environments. Results showed that AMs could effectively accumulate U-238, Sr-88, and Cs-133 from water, reaching equilibrium within 7 to 8 weeks with high concentration factors. These findings suggest that AMs can overcome the limitations of existing methods and offer a practical solution for radionuclide monitoring.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
