Journal
CANCER LETTERS
Volume 356, Issue 1, Pages 34-42Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.11.018
Keywords
Bystander effects; Non-targeted effects; Ionizing radiation; In vivo; Radiobiology; Carcinogenesis
Categories
Funding
- EU [MC-CIG-303514]
- European Union (European Social Fund -ESF)
- Greek national funds through the Operational Program Education and Lifelong Learning of the National Strategic Reference Framework (NSRF)-Research Funding Program: THALES [MIS 379346, COST Action CM1201]
- Greek national funds through the Operational Program Education and Lifelong Learning of the National Strategic Reference Framework (NSRF) - Research Funding Program: THALIS - UOA- [MIS: 377177]
- SSF Scholarships from OP Education and Lifelong Learning resources, European Social Fund (ESF) of the NSRF
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Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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