Article
Multidisciplinary Sciences
Igor Shuryak, Rainer K. Sachs, David J. Brenner
Summary: This study used a TE + NTE model to analyze the effects of different types of radiation on mouse tumorigenesis, and predicted tumor yield for a Mars-mission-relevant radiation mixture through modeling, enhancing knowledge about space radiation quality effects and health risks.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Munira Kadhim, Seda Tuncay Cagatay, Eman Mohammed Elbakrawy
Summary: Radiation-induced non-targeted effects play a significant role in radiation biology, with extracellular vesicles like exosomes potentially carrying nucleic acids and proteins as mediators of these effects. Current literature suggests that ionizing radiation can modulate the release and cargo content of exosomes, leading to functional changes in recipient cells. However, there are still significant gaps in our understanding, particularly regarding the modified exosome cargo post radiation exposure and the induced functional changes in recipient cells.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carmel Mothersill, Alan Cocchetto, Colin Seymour
Summary: This paper discusses the role of signaling in the effects of ionising radiation and presents a new model that explains the role of low dose effects in determining disease outcomes. The paper emphasizes the importance of signaling in coordinating responses across system levels, and proposes the concept of "infosome" to describe radiation-induced communication systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dietrich Averbeck
Summary: Non-targeted effects (NTE) are observed in both low-dose and high-dose ionizing radiation (IR) scenarios. Mitochondrial dysfunction and reorganization play a significant role in inducing NTE and radiobiological effects. These effects involve the release of molecular mediators and activation of cellular defense systems, leading to cell survival and anti-tumor radiation therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Annum Dawood, Carmel Mothersill, Colin Seymour
Summary: This review analyzes the historical narrative of low dose radiation effects on the immune system, particularly focusing on non-targeted effects like radiation induced bystander effect (RIBE), radiation induced genomic instability (RIGI), and abscopal effect (AE). Recent discovery of ultraviolet A photons emitted by irradiated cells triggering non-targeted effects raises the need for fresh examination of the field with respect to immune response. Limited research on immune response in the context of low dose ionizing radiation and non-targeted effects underscores the complexity and controversy surrounding the topic.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Review
Biology
Hiba Omer
Summary: Radiation is widely used in medicine for diagnosis and treatment, but the understanding of non-ionizing radiation is limited. This article aims to explain the fundamentals of different types of non-ionizing radiation to equip students and medical personnel with knowledge on medical applications.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Puja Upadhaya, Nathan Ryan, Peyton Roth, Travis Pero, Felipe Lamenza, Anna Springer, Pete Jordanides, Hasan Pracha, Darrion Mitchell, Steve Oghumu
Summary: This study demonstrates that tumor-targeted radiation therapy can generate tumor antigens that induce strong immune responses. These responses show comparable sensitivity but greater specificity for T cell activation compared to conventional antibodies. This information can be utilized to predict patient responses to radiation and immune therapy.
Article
Biochemistry & Molecular Biology
Ye-Ram Kim, Ah-Reum Han, Jin-Baek Kim, Chan-Hun Jung
Summary: Dendrobine inhibits IR-induced migration and invasion of NSCLC cells by suppressing SULF2 expression, demonstrating its potential as a therapeutic enhancer to overcome the malignant effects of radiation therapy.
Article
Plant Sciences
Xiaomeng Zhang, Xiaoying Chen, Lei Wang, An Wang, Changhao He, Zhongyu Shi, Shujing Zhang, Qian Fu, Wenhui Xu, Sumin Hu
Summary: This study confirmed the protective effects of YQJD decoction on ionizing radiation-induced spermatogenic cell injury. The findings may provide a new strategy for the application of Chinese herbs in radioprotection.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Himanshi Yadav, Rajeev Singh
Summary: In daily life, people are usually exposed to radiofrequency radiations (RFR). The effects of RFR on human physiology have been a major source of controversy since the WHO declared that these radiations are a type of environmental energy that interacts with the physiological functioning of the human body. This study aimed to investigate the influence of non-ionizing electromagnetic radiation from mobile phones on innate immune responses in a cell-specific and time-dependent manner.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biotechnology & Applied Microbiology
Swati, Vijayta D. Chadha
Summary: Despite its importance in diagnosis and treatment of cancer, ionizing radiation can lead to genotoxicity and side effects causing secondary carcinogenesis. While modern cancer radiation therapy has improved patient outcomes, the risk of radiation-related adverse effects remains a growing challenge. The off-targeted effects of IR involve various molecular events and may be influenced by epigenetic factors.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhangyu Dai, Wenjing Zhang, Mengke Shang, Huangqi Tang, Lijun Wu, Yuejin Wu, Ting Wang, Po Bian
Summary: This study explores the effect of DDR activation on the radiosensitivity of the vulva in C. elegans and discovers that it is mainly regulated by somatic DDR rather than germline DDR. The researchers also found that the signaling cascade of DDR may operate in a non-cell autonomous mode. The findings shed light on the regulation of DNA repair in the soma of C. elegans and may have implications for cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Margarita Pustovalova, Philipp Malakhov, Anastasia Guryanova, Maxim Sorokin, Maria Suntsova, Anton Buzdin, Andreyan N. N. Osipov, Sergey Leonov
Summary: Radioresistance is a major obstacle in the successful therapy of many cancers, including non-small cell lung cancer (NSCLC). By comparing the transcriptional changes of radioresistant NSCLC cells with parental cells using RNA-seq, differentially expressed genes associated with radioresistance were identified. These gene expressions reflect the complex biological processes involved in clinical cancer cell eradication and might serve as potential biomarkers and therapeutic targets for NSCLC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jingshu Meng, Yan Li, Chao Wan, Yajie Sun, Xiaomeng Dai, Jing Huang, Yan Hu, Yanan Gao, Bian Wu, Zhanjie Zhang, Ke Jiang, Shuangbing Xu, Jonathan F. Lovell, Yu Hu, Gang Wu, Honglin Jin, Kunyu Yang
Summary: The study highlights the importance of targeting senescence-like characteristics in cancer-associated fibroblasts to enhance radiosensitivity of non-small cell lung cancer cells, as well as alleviate radiation-induced pulmonary fibrosis.
Article
Biology
Iman M. Ahmad, Lisa Bartenhagen, Kimberly Michael, Maher Y. Abdalla
Summary: This study investigated the influence of occupational radiation exposure on oxidative stress and antioxidant levels among different hospital imaging professional groups. The results showed that imaging professionals exposed to radiation had higher levels of oxidative stress markers and antioxidant enzymes, compared to the control group. Furthermore, the results from the non-ionizing radiation group were significantly higher than the ionizing radiation group.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
