Article
Cell Biology
Lioba Klaas, Juliane Vier, Ian E. Gentle, Georg Hacker, Susanne Kirschnek
Summary: The study revealed that infection with MVA triggers multiple cell death pathways in macrophages, with lacking specific pathways leading to compensatory death through other pathways. Key molecules such as TNF, MAVS, and ZBP1 play critical roles in MVA-induced apoptosis, and the mode of cell death significantly impacts the cytokine response of infected cells.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Alexia Belavgeni, Francesca Maremonti, Wulf Tonnus, Marlena Stadtmueller, Shubhangi Gavali, Melodie Mallais, Karolin Flade, Anne Brucker, Jorunn Naila Becker, Kristina Beer, Mirela Tmava, Julian Stump, Florian Gembardt, Christian Hugo, Mauro Giacca, Benjamin G. Hale, Nikolaos Perakakis, Wei Sha, Derek A. Pratt, Andrew Schally, Stefan R. Bornstein, Andreas Linkermann
Summary: This study found that the VILP of LCDV-1 virus can function as a potent and highly specific inhibitor of ferroptosis, while human insulin is ineffective. The antioxidative and anti-death effects of LCDV-1 are achieved through the viral C-peptide. These findings suggest that ferroptosis may serve as a viral defense mechanism in lower organisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Dong Keon Oh, Hyun Sik Na, Joo Yeon Jhun, Jeong Su Lee, In Gyu Um, Seung Yoon Lee, Myeong Soo Park, Mi-La Cho, Sung-Hwan Park
Summary: This study investigated the effects of Bifidobacterium longum BORI (B. BORI) on pain, cartilage destruction, and inflammation in an OA rat model induced by monosodium iodoacetate (MIA). The results showed that B. BORI treatment reduced pain severity, protected cartilage, and inhibited cartilage loss in OA rats. In addition, it decreased the expression levels of inflammatory cytokines and catabolic markers. These findings suggest that oral administration of B. BORI has therapeutic potential in reducing pain, progression, and inflammation in OA.
Review
Immunology
Gerone A. Gonzales, Johnathan Canton
Summary: This article reviews the active cytosolic transfer of various macromolecular danger signals across endocytic organelle membranes. It highlights the developing trends and discusses the potential molecular mechanisms driving this emerging phenomenon.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Emer O'Connell, Ian S. Reynolds, Andreas U. Lindner, Manuela Salvucci, Tony O'Grady, Orna Bacon, Sanghee Cho, Elizabeth McDonough, Daniel Longley, Fiona Ginty, Deborah A. McNamara, John P. Burke, Jochen H. M. Prehn
Summary: Apoptotic and necroptotic mediators are differentially expressed in mucinous and non-mucinous colorectal cancers, suggesting potential targets for investigating cell death mechanisms in the mucinous subtype.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
A. Gielecinska, M. Kciuk, E. -B. Yahya, T. Ainane, S. Mujwar, R. Kontek
Summary: This review aims to demonstrate that various FDA-approved chemotherapeutic drugs can induce different types of cell death, providing an overview of their molecular mechanisms and interactions, as well as facilitating the exploration of cell death types induced by other chemotherapeutic agents.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Immunology
Erandi Perez-Figueroa, Pablo Alvarez-Carrasco, Enrique Ortega, Carmen Maldonado-Bernal
Summary: Neutrophils play a crucial role in innate immune response by executing various effector functions. When activated, they undergo cell death processes to ensure the proper elimination of pathogens and damaged cells, contributing to timely resolution of inflammation. Neutrophils' cell death mechanisms include apoptosis, pyroptosis, necrosis, and others, ultimately maintaining homeostasis in the organism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Elena Catanzaro, Olivier Feron, Andre G. Skirtach, Dmitri V. Krysko
Summary: Immunogenic cell death (ICD) is an emerging therapeutic strategy in cancer immunotherapy, and nanomaterials can be used to enhance the immunogenicity of cancer cells killed by anti-cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Xiaoyun Guo, Yi Chen, Qinghang Liu
Summary: Cell death is crucial in cardiac diseases such as ischemic injury, pathological remodeling, and heart failure. Recent studies have shown that a subset of necrotic cell death, known as regulated necrosis or necroptosis, is actively mediated through specific pathways involving death receptors and the activation of RIPK3 and MLKL. Necroptosis has been found to play an important role in myocardial homeostasis, ischemic injury, and pathological remodeling. Genetic and pharmacological interventions targeting necroptosis have shown cardioprotective effects.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nunzio Antonio Cacciola, Angela Salzano, Nunzia D'Onofrio, Tommaso Venneri, Paola De Cicco, Francesco Vinale, Orsolina Petillo, Manuela Martano, Paola Maiolino, Gianluca Neglia, Ciro Campanile, Lorella Severino, Carmine Merola, Francesca Borrelli, Maria Luisa Balestrieri, Giuseppe Campanile
Summary: Pharmacological research on milk whey has shown its potential therapeutic properties in modern medicine. This study focused on whey from Mediterranean buffalo milk and investigated its anticancer effects on colorectal cancer. The results revealed that whey was able to regulate protein expression in apoptotic and necroptotic pathways to inhibit tumor growth. The findings suggest that whey could be a valuable source of biomolecules for the treatment of colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Qian Zhang, Meng Jia, YunFu Wang, Qun Wang, Jianping Wu
Summary: Ischemic stroke is a major cause of morbidity and mortality worldwide. Various cell death mechanisms, including apoptosis, necrosis, autophagy, etc., play a role in brain tissue injury after cerebral ischemia-reperfusion. Understanding these mechanisms and their interactions is crucial.
NEUROCHEMICAL RESEARCH
(2022)
Article
Cell Biology
Huyan Meng, Guowei Wu, Xinsuo Zhao, Anhui Wang, Dekang Li, Yilun Tong, Taijie Jin, Ye Cao, Bing Shan, Shichen Hu, Ying Li, Lifeng Pan, Xiaoxu Tian, Ping Wu, Chao Peng, Junying Yuan, Guohui Li, Li Tan, Zhaoyin Wang, Ying Li
Summary: Necrostatin-34 (Nec-34), a small molecule inhibitor of RIPK1 kinase, stabilizes RIPK1 in an inactive conformation by occupying a distinct binding pocket. It can synergize with Nec-1s to inhibit RIPK1 in vitro and in vivo, providing a new strategy for targeting RIPK1 kinase and potential option for combinatorial therapy for RIPK1-mediated diseases.
Article
Medicine, Research & Experimental
Tianshan She, Qiuxiao Shi, Zhao Li, Yanru Feng, Hao Yang, Ze Tao, Heng Li, Jie Chen, Shisheng Wang, Yan Liang, Jingqiu Cheng, Xiaofeng Lu
Summary: Chemotherapeutic multidrug resistance (MDR) and TRAIL resistance are common in colorectal cancer (CRC) cells. Combination therapy of long-acting TRAIL and tumor-cell targeted photodynamic therapy (PDT) shows promising results in combating CRC with both types of resistance.
Review
Virology
Shannic-Le Kerr, Cynthia Mathew, Reena Ghildyal
Summary: Rhinoviruses are common causes of the common cold and can lead to more severe diseases in lower respiratory tract infections. These viruses hijack host cell pathways to suppress antiviral responses, and the mechanism of how they exit infected cells remains unclear.
Article
Cell Biology
Teodora Oltean, Emily Van San, Tatyana Divert, Tom Vanden Berghe, Xavier Saelens, Jonathan Maelfait, Nozomi Takahashi, Peter Vandenabeele
Summary: The study found that RIPK3 plays an important role in protection against influenza A virus, but this protection is only apparent within a limited dose range of IAV challenge. The protective outcome is independent of RIPK3 kinase activity and MLKL, suggesting that the platform function of RIPK3 is crucial for protection. FADD-dependent apoptosis also has a crucial additional effect in protection against IAV infection.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Andreas Maier, Julia Wiedemann, Felicitas Rapp, Franziska Papenfuss, Franz Roedel, Stephanie Hehlgans, Udo S. Gaipl, Gerhard Kraft, Claudia Fournier, Benjamin Frey
Summary: Radon, an imperceptible natural occurring radioactive noble gas, is a major contributor to radiation exposure from natural sources. It is both a concern for radiation protection and a therapy for inflammatory and degenerative diseases. The effects of radon on organisms involve various levels of interaction from physical diffusion to biological response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Lukas Kaesmann, Annemarie Schroeder, Benjamin Frey, Daniel F. Fleischmann, Tobias Gauer, Nadja Ebert, Markus Hecht, David Krug, Maximilian Niyazi, Matthias Maeurer
Summary: The scientific content of the manuscript, reputation of the journal, and a high impact factor are key factors determining attractiveness for peer reviewing in radiation oncology. The majority of participants prefer a double-blind peer review process and are willing to conduct more reviews if compensation is available, with options such as free access to journal articles, discounts for publication costs or congress fees, and expense allowances identified to increase attractiveness of the review process.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Cell Biology
Michael Hader, Simon Streit, Andreas Rosin, Thorsten Gerdes, Martin Wadepohl, Sander Bekeschus, Rainer Fietkau, Benjamin Frey, Eberhard Schluecker, Stephan Gekle, Udo S. Gaipl
Summary: The immune phenotype of tumor cells plays a crucial role in the anti-tumor immune response, and the combination of hyperthermia with radiotherapy can enhance this response. The frequency of hyperthermia systems may impact the immune phenotype of treated tumor cells, affecting the immunogenicity of tumors.
Article
Dermatology
Stefan Haskamp, Benjamin Frey, Ina Becker, Anja Schulz-Kuhnt, Imke Atreya, Carola Berking, David Pauli, Arif B. Ekici, Johannes Berges, Rotraut Moessner, Dagmar Wilsmann-Theis, Michael Sticherling, Steffen Uebe, Philipp Kirchner, Ulrike Hueffmeier
Summary: Generalized pustular psoriasis is characterized by increased proportions of CD4+ cytotoxic T lymphocytes and other CD4+ effector cells, decreased frequencies of naive CD4+ T cells, and elevated expression of FGFBP2 in patients with disease-contributing variants. Differentially expressed genes in neutrophils are enriched in genes of the classical complement activation pathway.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Environmental Sciences
Nerea Paz, Carola Hartel, Elena Nasonova, Anna-Jasmina Donaubauer, Benjamin Frey, Sylvia Ritter
Summary: In this exploratory study, the actions of radon in vivo and the possible health risks were investigated by analyzing chromosome aberrations in lymphocytes of patients undergoing radon spa therapy. The results showed no increased health risk after radon spa treatment, despite pronounced inter-individual differences in the number and types of aberrations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Thomas Weissmann, Stefan Speer, Florian Putz, Sebastian Lettmaier, Philipp Schubert, Maya Shariff, Sabine Semrau, Antoniu-Oreste Gostian, Maximilian Traxdorf, Sarina K. Mueller, Markus Eckstein, Matthias Hautmann, Jens von der Gruen, Marlen Haderlein, Benjamin Frey, Udo S. Gaipl, Christoph Bert, Heinrich Iro, Rainer Fietkau, Markus Hecht
Summary: Definitive radiochemotherapy for locally advanced head and neck squamous cell cancer achieves high control rates, but is often linked with long-term toxicity. A potential future direction is a de-escalation strategy focusing on treated volume rather than radiation dose. This study evaluates radiotherapy dose and volume parameters in a standard contouring approach compared to a revised volume-reduced contouring approach.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Bin Lan, Siyuan Zeng, Shuman Zhang, Xiaofan Ren, Yuming Xing, Isabella Kutschick, Susanne Pfeffer, Benjamin Frey, Nathalie Britzen-Laurent, Robert Gruetzmann, Nils Cordes, Christian Pilarsky
Summary: Pancreatic cancer is the fourth leading cause of cancer-related deaths in Western countries. Radiation therapy has not yielded satisfactory results in treating pancreatic cancer, and understanding radioresistance mechanisms and developing new therapeutic targets have become major challenges. In this study, the researchers used CRISPR-Cas9 screening and 3D cell culture to identify DYRK1A as a sensitive target for radiotherapy in pancreatic cancer. Furthermore, they showed that DYRK1A-targeted inhibitors could enhance the efficacy of radiotherapy. These findings support the use of CRISPR-Cas9 screening to identify novel therapeutic targets and develop strategies to improve radiotherapy efficacy in pancreatic cancer.
Article
Cell Biology
Lisa Deloch, Stephanie Hehlgans, Michael Rueckert, Andreas Maier, Annika Hinrichs, Ann-Sophie Flohr, Denise Eckert, Thomas Weissmann, Michaela Seeling, Falk Nimmerjahn, Rainer Fietkau, Franz Roedel, Claudia Fournier, Benjamin Frey, Udo S. Gaipl
Summary: Radon treatment is used for chronic painful inflammatory diseases, but the underlying molecular effects are not well understood. This study investigated the clinical outcomes and mechanisms of radon exposure using a mouse model and isolated cells. The results showed that radon exposure improved clinical disease progression score in mice, and this effect was not mediated by the anti-oxidative system or cell death. Instead, radon exposure slightly affected the immune system.
Article
Health Care Sciences & Services
Wibke Mueller-Seubert, Patrick Ostermaier, Raymund E. Horch, Luitpold Distel, Benjamin Frey, Aijia Cai, Andreas Arkudas
Summary: This study evaluated tissue perfusion after irradiation of random pattern flaps and found that indocyanine green angiography is more accurate in predicting necrotic areas. Preoperative fractional irradiation with a lower individual dose but a higher total dose has a more negative impact on flap perfusion.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Azzaya Sengedorj, Michael Hader, Lukas Heger, Benjamin Frey, Diana Dudziak, Rainer Fietkau, Oliver J. Ott, Stephan Scheidegger, Sergio Mingo Barba, Udo S. Gaipl, Michael Rueckert
Summary: Hyperthermia (HT) is a cancer treatment that locally heats the tumor to supraphysiological temperature, and it is an effective sensitizer for radiotherapy (RT) and chemotherapy. This study found that the sequence of HT and RT does not strongly affect the immune phenotype of breast cancer cells, but the combination of HT and RT upregulates immune suppressive immune checkpoint molecules. Therefore, the addition of immune checkpoint inhibitors should be considered in multimodal tumor treatments with RT and HT.
Article
Oncology
Eileen Stoll, Michael Hader, Michael Rueckert, Thomas Weissmann, Sebastian Lettmaier, Florian Putz, Markus Hecht, Rainer Fietkau, Andreas Rosin, Benjamin Frey, Udo S. Gaipl
Summary: The combination of radiotherapy and hyperthermia can increase apoptosis and necrosis in glioblastoma cells and promote the release of HSP70. The expression of immune checkpoint molecules varies at different temperatures and treatment combinations.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Chemistry, Multidisciplinary
Lisa Zschiesche, Christina Janko, Bernhard Friedrich, Benjamin Frey, Julia Band, Stefan Lyer, Christoph Alexiou, Harald Unterweger
Summary: Dextran-coated superparamagnetic iron oxide nanoparticles (SPIONDex) of different sizes can be used as contrast agents in magnetic resonance imaging (MRI) without interfering with immune response.
Article
Cell Biology
Ilka Scheer, Ina Becker, Charlotte Schmitter, Sabine Semrau, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey, Anna-Jasmina Donaubauer
Summary: The study investigates the reactivation of CMV during radiotherapy for brain tumors. It is found that patients with CMV reactivation have significantly higher levels of CD8+ T-EMRA cells. Additionally, the expression of CD27, CD28, and CD57 is associated with CMV infection status. The percentage of CD8+ T-EMRA cells may serve as a biomarker for predicting the risk of CMV reactivation during radiotherapy.
Article
Oncology
Thomas Weissmann, Sina Mansoorian, Matthias Stefan May, Sebastian Lettmaier, Daniel Hoefler, Lisa Deloch, Stefan Speer, Matthias Balk, Benjamin Frey, Udo S. Gaipl, Christoph Bert, Luitpold Valentin Distel, Franziska Walter, Claus Belka, Sabine Semrau, Heinrich Iro, Rainer Fietkau, Yixing Huang, Florian Putz
Summary: This study introduces two novel methods for automatically analyzing the distribution of nodal metastases in head and neck cancer patients. The deep learning method accurately assigns lymph node metastases to different levels, while the registration-based method allows for the analysis and visualization of the 3D probability distribution of metastases without predefined level boundaries.
Article
Health Care Sciences & Services
Wibke Mueller-Seubert, Patrick Ostermaier, Raymund E. Horch, Luitpold Distel, Benjamin Frey, Ramona Erber, Andreas Arkudas
Summary: Different irradiation regimens have different effects on random-pattern flaps. A higher total dose of postoperative irradiation may increase flap necrosis, and irradiation can increase the expression of VEGF and HIF-1α.
JOURNAL OF PERSONALIZED MEDICINE
(2023)