Parkinson’s Disease: The Mitochondria-Iron Link

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

New insights into cellular α-synuclein homeostasis in health and disease

(2016) Ulf Dettmer et al.   CURRENT OPINION IN NEUROBIOLOGY

Parkinson's disease as a result of aging

(2015) Manuel Rodriguez et al.   AGING CELL

Neurodegeneration with Brain Iron Accumulation: Genetic Diversity and Pathophysiological Mechanisms

(2015) Esther Meyer et al.   Annual Review of Genomics and Human Genetics

The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death

(2015) Natalia P. Mena et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PINK1 activation–turning on a promiscuous kinase

(2015) Liesbeth Aerts et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Iron –sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery

(2015) Nunziata Maio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Piperazine derivatives as iron chelators: a potential application in neurobiology

(2015) S. Abdelsayed et al.   BIOMETALS

Pink1 protects cortical neurons from thapsigargin-induced oxidative stress and neuronal apoptosis

(2015) Lin Li et al.   BIOSCIENCE REPORTS

Cationic Albumin-Conjugated Chelating Agent as a Novel Brain Drug Delivery System in Neurodegeneration

(2015) Golnaz Kamalinia et al.   Chemical Biology & Drug Design

Evidence for a common biological pathway linking three Parkinson's disease-causing genes:parkin,PINK1andDJ-1

(2015) Celia van der Merwe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich׳s ataxia

(2015) Juan A. Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating iron

(2015) Y.-Q. Wang et al.   FREE RADICAL RESEARCH

Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial

(2015)   LANCET NEUROLOGY

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders

(2015) Natalia P. Mena et al.   MITOCHONDRION

α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons

(2015) Richard Ortega et al.   MOLECULAR NEUROBIOLOGY

High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry

(2015) Nadya Pyatigorskaya et al.   MOVEMENT DISORDERS

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

(2015) Guangwei Du et al.   MOVEMENT DISORDERS

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging

(2015) Orit Bar-Am et al.   NEUROBIOLOGY OF AGING

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

(2015) Manik C. Ghosh et al.   NEUROBIOLOGY OF DISEASE

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

(2015) Peng Lei et al.   NEUROBIOLOGY OF DISEASE

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

(2015) M. Yue et al.   NEUROBIOLOGY OF DISEASE

Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease

(2015) Stephen Mullin et al.   NEUROLOGIC CLINICS

Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson’s disease

(2015) L.-H. You et al.   NEUROSCIENCE

Longitudinal midbrain changes in early Parkinson's disease: Iron content estimated from R2*/MRI

(2015) Marguerite Wieler et al.   PARKINSONISM & RELATED DISORDERS

Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells

(2015) Junghyung Park et al.   TOXICOLOGY

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Mitochondrial Dysfunction andα-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?

(2015) Michela Zaltieri et al.   Parkinsons Disease

Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP+/MPTP-Lesioned Dopaminergic Neurons

(2015) Pabla Aguirre et al.   PLoS One

Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD

(2015) Yang Hu et al.   PLoS One

Superoxide dismutase as a target of clioquinol-induced neurotoxicity

(2014) Kazuyuki Kawamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson's Disease

(2014) Angelique Camilleri et al.   CNS Neuroscience & Therapeutics

The Novel Multi-Target Iron Chelator, M30 Modulates HIF-1α-Related Glycolytic Genes and Insulin Signaling Pathway in the Frontal Cortex of APP/PS1 Alzheimer’s Disease Mice

(2014) Danit Mechlovich et al.   Current Alzheimer Research

Iron Chelating Strategies in Systemic Metal Overload, Neurodegeneration and Cancer

(2014) Elzbieta Gumienna-Kontecka et al.   CURRENT MEDICINAL CHEMISTRY

Bioenergetics and Mitochondrial Dysfunction in Aging: Recent Insights for a Therapeutical Approach

(2014) Antonino Romano et al.   CURRENT PHARMACEUTICAL DESIGN

LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis

(2014) A. Raquel Esteves et al.   EXPERIMENTAL NEUROLOGY

Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction

(2014) Jin-Sung Park et al.   HUMAN MOLECULAR GENETICS

The Perplexing Paradox of Paraquat: The Case for Host-Based Susceptibility and Postulated Neurodegenerative Effects

(2014) Byron C. Jones et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

α-synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: Implications in the pathogenesis of Parkinson's disease

(2014) Aritri Bir et al.   JOURNAL OF NEUROCHEMISTRY

Distinct neurological disorders with ATP1A3 mutations

(2014) Erin L Heinzen et al.   LANCET NEUROLOGY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications

(2014) Iakov N. Rudenko et al.   Neurotherapeutics

Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

(2014) Jason Howitt et al.   PLoS One

Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—A mechanistic approach

(2014) Maria Teresa Baltazar et al.   TOXICOLOGY LETTERS

The Role of Iron in Prion Disease and Other Neurodegenerative Diseases

(2014) Neena Singh   PLoS Pathogens

Mutations in theATP13A2Gene and Parkinsonism: A Preliminary Review

(2014) Xinglong Yang et al.   Biomed Research International

Fixating on metals: new insights into the role of metals in nodulation and symbiotic nitrogen fixation

(2014) Manuel González-Guerrero et al.   Frontiers in Plant Science

Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons

(2014) Carol D. SanMartín et al.   Frontiers in Molecular Neuroscience

The physiological functions of iron regulatory proteins in iron homeostasis - an update

(2014) De-Liang Zhang et al.   Frontiers in Pharmacology

The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders

(2014) Pamela J. Urrutia et al.   Frontiers in Pharmacology

Special delivery: distributing iron in the cytosol of mammalian cells

(2014) Caroline C. Philpott et al.   Frontiers in Pharmacology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Calcium dysregulation in Parkinson’s disease

(2013) Anthony H.V. Schapira   BRAIN

Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model

(2013) Fabia Febbraro et al.   EXPERIMENTAL NEUROLOGY

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

(2013) Patrick J. Schultheis et al.   HUMAN MOLECULAR GENETICS

Role of α-synuclein aggregation and the nuclear factor E2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity

(2013) Qing He et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pesticides, depression and suicide: A systematic review of the epidemiological evidence

(2013) Carmen Freire et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

The Parkinson's disease-associated genePINK1protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1

(2013) Yanxin Zhao et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity

(2013) Wei Xiang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Pro-inflammatory cytokine-mediated ferroportin down-regulation contributes to the nigral iron accumulation in lipopolysaccharide-induced Parkinsonian models

(2013) Z. Zhang et al.   NEUROSCIENCE

Modeling Lewy pathology propagation in Parkinson's disease

(2013) Kelvin C. Luk et al.   PARKINSONISM & RELATED DISORDERS

Erythroid Heme Biosynthesis and Its Disorders

(2013) H. A. Dailey et al.   Cold Spring Harbor Perspectives in Medicine

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

(2013) Giovanni Esposito et al.   PLoS Genetics

Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study

(2013) Irene Pichler et al.   PLOS MEDICINE

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Insight into the evolution of the iron oxidation pathways

(2012) Marianne Ilbert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Intracellular iron trafficking: role of cytosolic ligands

(2012) Maya Shvartsman et al.   BIOMETALS

Iron toxicity in neurodegeneration

(2012) Marco T. Núñez et al.   BIOMETALS

Inhibition of Drp1 provides neuroprotection in vitro and in vivo

(2012) J Grohm et al.   CELL DEATH AND DIFFERENTIATION

Monoamine Oxidase Inhibitors as Neuroprotective Agents in Age-Dependent Neurodegenerative Disorders

(2012) Makoto Naoi et al.   CURRENT PHARMACEUTICAL DESIGN

Iron speciation in the cytosol: an overview

(2012) Robert C. Hider et al.   DALTON TRANSACTIONS

Coming into View: Eukaryotic Iron Chaperones and Intracellular Iron Delivery: FIGURE 1.

(2012) Caroline C. Philpott   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron accumulation in Parkinson’s disease

(2012) Hideki Mochizuki et al.   JOURNAL OF NEURAL TRANSMISSION

Excess iron harms the brain: the syndromes of neurodegeneration with brain iron accumulation (NBIA)

(2012) Susanne A. Schneider et al.   JOURNAL OF NEURAL TRANSMISSION

The role of iron in neurodegeneration—Mössbauer spectroscopy, electron microscopy, enzyme-linked immunosorbent assay and neuroimaging studies

(2012) Jolanta Galazka-Friedman et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice

(2012) Lana Kupershmidt et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Brain iron deposition fingerprints in Parkinson's disease and progressive supranuclear palsy

(2012) Kai Boelmans et al.   MOVEMENT DISORDERS

Central nervous system damage due to acute paraquat poisoning: A neuroimaging study with 3.0T MRI

(2012) Bailin Wu et al.   NEUROTOXICOLOGY

Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice

(2012) Minjuan Bian et al.   PLoS One

Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

(2012) Y. Ichikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling

(2012) Masato Katsuyama et al.   TOXICOLOGY

Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of Parkinson’s disease

(2012) Xi-Xun Du et al.   Neuroscience Bulletin

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

(2011) Anna Pilsl et al.   ACTA NEUROPATHOLOGICA

Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease

(2011) Michael Li-Hsuan Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of mitochondrial complex I inhibition on Fe–S cluster protein activity

(2011) Natalia P. Mena et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

(2011) Hung-Li Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glutathione: a key component of the cytoplasmic labile iron pool

(2011) Robert C. Hider et al.   BIOMETALS

Dopamine D2/D3 Agonists with Potent Iron Chelation, Antioxidant and Neuroprotective Properties: Potential Implication in Symptomatic and Neuroprotective Treatment of Parkinson’s Disease

(2011) Sanjib Gogoi et al.   ChemMedChem

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

(2011) David Ramonet et al.   HUMAN MOLECULAR GENETICS

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Mutations inLRRK2increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

(2011) Dario C. Angeles et al.   HUMAN MUTATION

Loss of ABCB7 gene: pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13)

(2011) Kazuya Sato et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Iron MediatesN-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity

(2011) Pablo Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Regulatory Protein 1 Outcompetes Iron Regulatory Protein 2 in Regulating Cellular Iron Homeostasis in Response to Nitric Oxide

(2011) Agnieszka Styś et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin-Mediated Protection of Dopaminergic Neurons in a Chronic MPTP-Minipump Mouse Model of Parkinson Disease

(2011) Toru Yasuda et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

HFE Gene Variants Affect Iron in the Brain

(2011) Wint Nandar et al.   JOURNAL OF NUTRITION

Dietary intake of metals and risk of Parkinson's disease: A case-control study in Japan

(2011) Yoshihiro Miyake et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

ATP13A2-related neurodegeneration (PARK9) without evidence of brain iron accumulation

(2011) Hsin Fen Chien et al.   MOVEMENT DISORDERS

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

(2011) Aaron M. Gusdon et al.   NEUROBIOLOGY OF DISEASE

Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain

(2011) L. Kupershmidt et al.   NEUROSCIENCE

Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome

(2011) Mario A. Acuña et al.   NEUROTOXICITY RESEARCH

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3

(2011) P. M. Rappold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Transferrin-iron routing to the cytosol and mitochondria as studied by live and real-time fluorescence

(2010) Maya Shvartsman et al.   BIOCHEMICAL JOURNAL

Redox Reactions of the α-Synuclein−Cu2+Complex and Their Effects on Neuronal Cell Viability

(2010) Chengshan Wang et al.   BIOCHEMISTRY

Paraquat and Parkinson's disease

(2010) C Berry et al.   CELL DEATH AND DIFFERENTIATION

Cytosolic Monothiol Glutaredoxins Function in Intracellular Iron Sensing and Trafficking via Their Bound Iron-Sulfur Cluster

(2010) Ulrich Mühlenhoff et al.   Cell Metabolism

Mitochondrial dynamics in cell death and neurodegeneration

(2010) Dong-Hyung Cho et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Up-Regulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30

(2010) Y. Avramovich-Tirosh et al.   Current Alzheimer Research

Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and Its Analogues as Highly Potent Dopamine D2/D3 Agonists and as Iron Chelator: In Vivo Activity Indicates Potential Application in Symptomatic and Neuroprotective Therapy for Parkinson’s Disease

(2010) Balaram Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain iron metabolism and its perturbation in neurological diseases

(2010) Robert R. Crichton et al.   JOURNAL OF NEURAL TRANSMISSION

Metalloproteomics and metal toxicology of α-synuclein

(2010) Aaron Santner et al.   Metallomics

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations

(2010) Maria I. Behrens et al.   MOVEMENT DISORDERS

ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation

(2010) Susanne A. Schneider et al.   MOVEMENT DISORDERS

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased Reactive Oxygen Species Production in the Brain After Repeated Low-Dose Pesticide Paraquat Exposure in Rats. A Comparison with Peripheral Tissues

(2010) Katarzyna Kuter et al.   NEUROCHEMICAL RESEARCH

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Paradoxical Role of Prion Protein Aggregates in Redox-Iron Induced Toxicity

(2010) Dola Das et al.   PLoS One

A Disruption in Iron-Sulfur Center Biogenesis via Inhibition of Mitochondrial Dithiol Glutaredoxin 2 May Contribute to Mitochondrial and Cellular Iron Dysregulation in Mammalian Glutathione-Depleted Dopaminergic Cells: Implications for Parkinson's Disease

(2009) Donna W. Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death

(2009) Julia Grohm et al.   BRAIN BEHAVIOR AND IMMUNITY

Clioquinol inhibits NGF-induced Trk autophosphorylation and neurite outgrowth in PC12 cells

(2009) Kunihiko Asakura et al.   BRAIN RESEARCH

Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

(2009) Joshua R. Veatch et al.   CELL

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthetic and natural iron chelators: therapeutic potential and clinical use

(2009) Heather C Hatcher et al.   Future Medicinal Chemistry

Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

(2009) Mordhwaj S. Parihar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation

(2009) A. Kathrin Lutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of α-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes

(2009) Yong Peng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

Metal Ion Physiopathology in Neurodegenerative Disorders

(2009) Silvia Bolognin et al.   NEUROMOLECULAR MEDICINE

Iron transport in Parkinson's disease

(2009) E.C. Hirsch   PARKINSONISM & RELATED DISORDERS

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H2O2-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures

(2009) David Cantu et al.   PLoS One

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Dietary Iron Intake and Risk of Parkinson's Disease

(2008) G. Logroscino et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY

Iron-Based Redox Switches in Biology

(2008) F. Wayne Outten et al.   ANTIOXIDANTS & REDOX SIGNALING

The PINK1–Parkin pathway is involved in the regulation of mitochondrial remodeling process

(2008) Jeehye Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The production of reactive oxygen species by complex I

(2008) Judy Hirst et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Iron, the substantia nigra and related neurological disorders

(2008) Amanda M. Snyder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Parkinson patient fibroblasts show increased alpha-synuclein expression

(2008) Hans-Hermann Hoepken et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

(2008) Shuzhen Zhang et al.   NEUROBIOLOGY OF AGING

Genetics of iron regulation and the possible role of iron in Parkinson's disease

(2008) Shannon L. Rhodes et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

(2008) Shaik Shavali et al.   NEUROSCIENCE LETTERS

HFE gene mutations in a population of Italian Parkinson's disease patients

(2008) Giorgio Biasiotto et al.   PARKINSONISM & RELATED DISORDERS

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

(2008) Alison Wood-Kaczmar et al.   PLoS One

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

(2008) C. A. Gautier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

(2008) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concerted Action of Metals and Macromolecular Crowding on the Fibrillation of α-Synuclein

(2008) Larissa Munishkina et al.   PROTEIN AND PEPTIDE LETTERS

Iron–sulfur cluster biogenesis and human disease

(2008) Tracey A. Rouault et al.   TRENDS IN GENETICS

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology

Complex I deficiency in Parkinson's disease frontal cortex

(2007) W. Davis Parker et al.   BRAIN RESEARCH

Brain iron pathways and their relevance to Parkinson's disease

(2003) D Berg et al.   JOURNAL OF NEUROCHEMISTRY