Evidence for a common biological pathway linking three Parkinson's disease-causing genes:parkin,PINK1andDJ-1

PINK1 and Its Familial Parkinson's Disease-Associated Mutation Regulate Brain Vascular Endothelial Inflammation

(2014) Wang Yunfu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

(2014) L F Burbulla et al.   Cell Death & Disease

DJ-1 contributes to adipogenesis and obesity-induced inflammation

(2014) Jung-Min Kim et al.   Scientific Reports

PINK1-mediated Phosphorylation of Miro Inhibits Synaptic Growth and Protects Dopaminergic Neurons in Drosophila

(2014) Pei-I Tsai et al.   Scientific Reports

The systems biology of mitochondrial fission and fusion and implications for disease and aging

(2013) Anuradha Chauhan et al.   BIOGERONTOLOGY

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

(2013) I. Tai-Nagara et al.   BLOOD

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells andDrosophila

(2013) Saera Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulated Parkin expression protects mitochondrial homeostasis in DJ-1 konckdown cells and cells overexpressing the DJ-1 L166P mutation

(2013) Chunyan Chang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

Neuroprotective Function of DJ-1 in Parkinson’s Disease

(2013) Hiroyoshi Ariga et al.   Oxidative Medicine and Cellular Longevity

Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscle

(2013) Varuna C. Banduseela et al.   PHYSIOLOGICAL GENOMICS

Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model

(2013) Jun-yi Zhu et al.   PLoS One

Emerging roles of E3 ubiquitin ligases in autophagy

(2013) Ersheng Kuang et al.   TRENDS IN BIOCHEMICAL SCIENCES

PARK2 Mediates Interleukin 6 and Monocyte Chemoattractant Protein 1 Production by Human Macrophages

(2013) Louis de Léséleuc et al.   PLoS Neglected Tropical Diseases

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IRF-1 and miRNA126 Modulate VCAM-1 Expression in Response to a High-Fat Meal

(2012) Chongxiu Sun et al.   CIRCULATION RESEARCH

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease

(2012) Olga Corti et al.   CURRENT OPINION IN NEUROBIOLOGY

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons

(2012) Alvin P. Joselin et al.   HUMAN MOLECULAR GENETICS

Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode

(2012) Dorothea Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 Protects Against Dopamine Toxicity: Implications for Parkinson's Disease and Aging

(2012) N. Lev et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease

(2012) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

DJ-1 Null Dopaminergic Neuronal Cells Exhibit Defects in Mitochondrial Function and Structure: Involvement of Mitochondrial Complex I Assembly

(2012) Jun Young Heo et al.   PLoS One

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

(2012) B. N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes

(2012) Deepak Jain et al.   Journal of Molecular Cell Biology

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

(2011) Kye-Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

(2010) Sumihiro Kawajiri et al.   FEBS LETTERS

Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis

(2010) Lena F. Burbulla et al.   HUMAN MOLECULAR GENETICS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Human DJ-1-specific Transcriptional Activation of Tyrosine Hydroxylase Gene

(2010) Shizuma Ishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

(2010) Guido Krebiehl et al.   PLoS One

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

(2010) Angela C. Poole et al.   PLoS One

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Parkin stabilizes PINK1 through direct interaction

(2009) Kahori Shiba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†

(2009) Andreas Weihofen et al.   BIOCHEMISTRY

PINK1 function in health and disease

(2009) Emma Deas et al.   EMBO Molecular Medicine

Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology

(2009) A. Grünewald et al.   EXPERIMENTAL NEUROLOGY

Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

(2009) Hansruedi Büeler   EXPERIMENTAL NEUROLOGY

Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling

(2009) Anna Sandebring et al.   FEBS Journal

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

(2009) Philipp J. Kahle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling

(2009) D. Sha et al.   HUMAN MOLECULAR GENETICS

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

(2009) Jeff Blackinton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation

(2009) A. Kathrin Lutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

(2009) Hui Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular interaction between parkin and PINK1 in mammalian neuronal cells

(2009) Ji Won Um et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function

(2009) Eleanor J. Davison et al.   PROTEOMICS

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The PINK1–Parkin pathway is involved in the regulation of mitochondrial remodeling process

(2008) Jeehye Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites

(2008) P. W. Franks et al.   FASEB JOURNAL

Evaluation of a SNP map of 6q24–27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population

(2008) Tennille S. Leak et al.   HUMAN GENETICS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Mortalin: A Protein Associated With Progression of Parkinson Disease?

(2008) Min Shi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

(2008) Alison Wood-Kaczmar et al.   PLoS One

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

(2008) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

(2008) H. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA