Review
Cardiac & Cardiovascular Systems
Luke S. Dunaway, Jennifer S. Pollock
Summary: HDAC1 plays a crucial regulatory role in endothelial biology by influencing major endothelial functions such as angiogenesis, inflammatory signaling, redox homeostasis, and nitric oxide signaling.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemical Research Methods
Zhongyun Jiang, Sidi Liu, Xiang Xiao, Guimei Jiang, Qing Qu, Xingxing Miao, Renfei Wu, Rui Shi, Ruochen Guo, Jian Liu
Summary: In this study, a technique using droplet biosensors for the detection of nitric oxide (NO) secreted by a single macrophage under inflammatory stimuli was reported. The approach allows for studying the interactions between bacteria and macrophages at the single cell level.
Article
Biochemistry & Molecular Biology
Dennis J. J. Stuehr, Pranjal Biswas, Yue Dai, Arnab Ghosh, Sidra Islam, Dhanya Thamaraparambil Jayaram
Summary: A natural heme deficiency outside of circulation affects the heme contents and functions of heme proteins in cells and tissues. Recently, it was found that nitric oxide (NO) can trigger or repress intracellular heme deployment in a concentration-dependent hormetic manner. This discovery reveals a new role for NO in controlling heme deployment and heme protein functions, which has implications for various biological processes.
Article
Biochemistry & Molecular Biology
Md Atikur Rahman, Ahmad Humayan Kabir, Yowook Song, Sang-Hoon Lee, Mirza Hasanuzzaman, Ki-Won Lee
Summary: This study demonstrates that nitric oxide (NO) plays a crucial role in restoring iron (Fe) deficiency-induced growth inhibition and oxidative stress in alfalfa. By upregulating specific genes, NO helps alleviate the negative effects of Fe deficiency by inhibiting oxidative stress and enhancing antioxidant defense mechanisms.
Article
Chemistry, Multidisciplinary
Chengchen Zhang, Biyao Yang, Joanna M. Biazik, Richard F. Webster, Wanjie Xie, Jianbo Tang, Francois-Marie Allioux, Roozbeh Abbasi, Maedehsadat Mousavi, Ewa M. Goldys, Kristopher A. Kilian, Rona Chandrawati, Dorna Esrafilzadeh, Kourosh Kalantar-Zadeh
Summary: This study reveals the mechanisms of gallium as an anti-inflammatory by delivering gallium nanodroplets into macrophages. The gallium nanodroplets selectively inhibit nitric oxide production without affecting the accumulation of pro-inflammatory mediators. This study provides new insights for the use of gallium in anti-inflammatory and future biomedical applications.
Article
Environmental Sciences
Jun Wang, Bowen Liu, Zhiwei Jin, Longna Li, Wenbiao Shen
Summary: The production of nitric oxide (NO) stimulated by argon plays a crucial role in enhancing crop tolerance to cadmium (Cd) stress and improving iron homeostasis.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Won Jin Lee, Hyuk Gyoon Lee, Jinwoo Hur, Gyeong Hee Lee, Jun Pil Won, Eunsu Kim, Jung Seok Hwang, Han Geuk Seo
Summary: The nuclear receptor PPAR delta plays a regulatory role in cellular iron homeostasis, and its activation can alleviate 6-OHDA-induced neurotoxicity. PPAR delta activation reduces iron accumulation and suppresses the generation of reactive oxygen species and lipid peroxides.
Article
Chemistry, Multidisciplinary
Haixing Wang, Sien Lin, Lu Feng, Baozhen Huang, Xuan Lu, Zhengmeng Yang, Zhaowei Jiang, Yu-Cong Li, Xiaoting Zhang, Ming Wang, Bin Wang, Lingchi Kong, Qi Pan, Shanshan Bai, Yuan Li, Yongkang Yang, Wayne Yuk Wai Lee, Peter D. Currie, Changshuang Lin, Yanfu Jiang, Juyu Chen, Micky D. Tortorella, Hongyi Li, Gang Li
Summary: Recent studies have shown that T cells play a role in maintaining bone homeostasis, suggesting them as potential therapeutic targets for bone-related conditions. This study reports that low-dose administration of SEC2 2M-118 can alleviate bone loss in mice by modulating T cells. The treatment increases trabecular bone mass by promoting bone formation and this effect is diminished in T-cell-deficient mice. The key factor mediating these effects is IFN-gamma, which stimulates signaling pathways and enhances osteogenic differentiation.
Review
Plant Sciences
Lovely Mahawar, Kesava Priyan Ramasamy, Aparna Pandey, Sheo Mohan Prasad
Summary: Iron is a crucial micronutrient for plant growth and human nutrition. Understanding iron homeostasis in plants is essential for improving growth and development and addressing iron deficiency in low-income rural populations. This review focuses on the role of signaling molecules, particularly phytohormones and nitric oxide, and their coordination in iron homeostasis in agriculturally important crops. These signaling molecules play a vital role in up-regulating iron acquisition genes, facilitating iron translocation, and enhancing iron accessibility, making them important biofortification strategies for addressing hidden hunger.
PLANT GROWTH REGULATION
(2023)
Article
Chemistry, Analytical
Bingbing Zheng, Yang Tian, Senyao Liu, Jieyu Yang, Fapu Wu, Hu Xiong
Summary: Noninvasive visualization of liver polarity by using fluorescence imaging technology is achieved using a new cell membrane-targeted NIR small molecular probe (N-BPM-C ( 10 )). This probe exhibits polarity-dependent fluorescence and can rapidly light up cell membranes, making it useful for in vivo imaging studies. Importantly, it has been successfully applied to visualize liver polarity changes in DILI mice.
ANALYTICAL CHEMISTRY
(2023)
Review
Cell Biology
Shiwen Ma, Yao Mawulikplimi Adzavon, Xiaohu Wen, Pengxiang Zhao, Fei Xie, Mengyu Liu, Xuemei Ma
Summary: Ferroptosis is a newly defined programmed cell death process that differs from other types of programmed cell death. It can be regulated by antioxidants and iron-chelating agents, and it affects cancer progression by influencing iron ion deposition and lipid peroxidation. Significant progress has been made in understanding the molecular mechanism of ferroptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Thomas P. Buters, Pieter Hameeteman, Iris M. E. Jansen, Floris C. van Hindevoort, Wouter ten Voorde, Hendrika W. Grievink, Mascha Schoonakker, Marieke L. de Kam, Derek W. Gilroy, Gary Feiss, Robert Rissmann, Manon A. A. Jansen, Jacobus Burggraaf, Matthijs Moerland
Summary: In this study, the inhibitory effects of oral and topical corticosteroid treatment on intradermal lipopolysaccharide (LPS) responses were evaluated. The results showed that corticosteroids significantly suppressed the clinical inflammatory response and reduced the secretion of inflammatory mediators. This experimental model is effective in evaluating the effects of anti-inflammatory drugs.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Yan Yan, Karl N. Krecke, Aditi S. Bapat, Tingyuan Yang, Michael W. Lopresti, Douglas G. Mashek, Ameeta Kelekar
Summary: The study revealed a novel role for PHLPP2 in targeting AMP-activated protein kinase (AMPK) to suppress the survival response of leukemia cells under glucose limitation. Silencing PHLPP2 prolonged the survival of leukemia cells by promoting AMPK-mediated fatty acid oxidation. This discovery could lead to better therapeutic strategies for both cancer and metabolic diseases.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Hua Wang, Chuan Jiang, Yakun Yang, Jinghan Li, Yihan Wang, Chaonan Wang, Yonggang Gao
Summary: Resveratrol (RES) has protective effects against iron overload-induced liver fibrosis, possibly through its antioxidant, anti-inflammatory, antiapoptotic properties, and regulation of iron homeostasis.
Article
Plant Sciences
Ziqi Gao, Jiayuan Zhang, Jie Zhang, Wenxiu Zhang, Linlin Zheng, Tebuqin Borjigin, Yingchun Wang
Summary: This study found that nitric oxide (NO) can alleviate salt stress damage in Nitraria tangutorum seedlings by increasing antioxidants levels and activities, regulating related gene expression, and promoting ion transport.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Reproductive Biology
M. Ogorek, S. Herman, O. Pierzchala, A. Bednarz, Z. Rajfur, Z. Baster, P. Grzmil, R. R. StarzyNski, M. Szudzik, A. Jonczy, P. Lipinski, M. Lenartowicz
BIOLOGY OF REPRODUCTION
(2019)
Article
Multidisciplinary Sciences
Aleksandra Bednarz, Pawel Lipinski, Rafal R. Starzynski, Mateusz Tomczyk, Witold Nowak, Olga Mucha, Mateusz Ogorek, Olga Pierzchala, Aneta Jonczy, Robert Staron, Julia Smierzchalska, Zenon Rajfur, Zbigniew Baster, Alicja Jozkowicz, Malgorzata Lenartowicz
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Mateusz Szudzik, Pawel Lipinski, Aneta Jonczy, Rafal Mazgaj, Marek Pieszka, Marian Kamyczek, Ewa Smuda, Rafal R. Starzynski
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Oncology
Julia A. Braun, Anja L. Herrmann, Johanna Blase, Kristin Frensemeier, Julia Bulkescher, Martin Scheffner, Bruno Galy, Karin Hoppe-Seyler, Felix Hoppe-Seyler
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Iart Luca Shytaj, Bojana Lucic, Mattia Forcato, Carlotta Penzo, James Billingsley, Vibor Laketa, Steven Bosinger, Mia Stanic, Francesco Gregoretti, Laura Antonelli, Gennaro Oliva, Christian K. Frese, Aleksandra Trifunovic, Bruno Galy, Clarissa Eibl, Guido Silvestri, Silvio Bicciato, Andrea Savarino, Marina Lusic
Article
Biochemistry & Molecular Biology
Olga Haberkiewicz, Pawel Lipinski, Rafal R. Starzynski, Aneta Jonczy, Patrycja Kurowska, Mateusz Ogorek, Aleksandra Bednarz, Sylwia Herman, Dawid Hatala, Pawel Grzmil, Zenon Rajfur, Zbigniew Baster, Malgorzata Lenartowicz
Summary: Kidneys play a unique role in copper redistribution in the body, controlling copper uptake and release through copper transporters. The study showed changes in the expression and localization of CTR1 protein in the kidneys of copper-overloaded mosaic mutant mice, preventing copper transport and protecting cells from copper toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Magdalena Ogluszka, Pawel Lipinski, Rafal R. Starzynski
Summary: Telomeres play a key role in protecting chromosome ends and maintaining genome stability, but they shorten with aging. Short telomeres are associated with age-related diseases, but the variability in telomere shortening suggests it is modifiable. Studies have explored the impact of omega-3 fatty acids on telomere shortening, with most indicating a beneficial effect on telomere length.
Article
Multidisciplinary Sciences
Michael Bonadonna, Sandro Altamura, Elisabeth Tybl, Gael Palais, Maria Qatato, Maria Polycarpou-Schwarz, Martin Schneider, Christina Kalk, Wibke Ruediger, Alina Ertl, Natasha Anstee, Ruzhica Bogeska, Dominic Helm, Michael D. Milsom, Bruno Galy
Summary: Iron plays a crucial role in hemoglobin synthesis in red blood cells, but recent studies have shown that it also has a broader role in hematopoiesis and immune system formation. Iron availability is regulated by iron-regulatory protein 1 and IRP2, which are essential for neutrophil development and differentiation. This study reveals the previously unrecognized importance of IRPs and iron metabolism in the formation of the innate immune system.
Article
Multidisciplinary Sciences
Joe N. Frost, Sarah K. Wideman, Alexandra E. Preston, Megan R. Teh, Zhichao Ai, Lihui Wang, Amy Cross, Natasha White, Yavuz Yazicioglu, Michael Bonadonna, Alexander J. Clarke, Andrew E. Armitage, Bruno Galy, Irina A. Udalova, Hal Drakesmith
Summary: Low plasma iron induced by hepcidin inhibits neutrophil production and alters their effector functions, while having no significant effect on other types of white blood cells. Antagonizing endogenous hepcidin can enhance neutrophil production during acute inflammation. These findings suggest that plasma iron plays a role in modulating the profile of innate immunity, with potential therapeutic implications.
Article
Multidisciplinary Sciences
Joel I. Perez-Perri, Dunja Ferring-Appel, Ina Huppertz, Thomas Schwarzl, Sudeep Sahadevan, Frank Stein, Mandy Rettel, Bruno Galy, Matthias W. Hentze
Summary: The eRIC method was used to characterize the RNA-bound proteomes of three different mouse organs, revealing over 1300 active RNA-binding proteins, with nearly a quarter being previously unknown. Systematic differences in RNA binding were also observed between organs and cultured cells.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Bruno Galy, Marcus Conrad, Martina Muckenthaler
Summary: This review discusses the importance of iron in cellular functions and its tightly regulated mechanisms in mammals. Cells acquire, traffick, and export iron through various sensory and regulatory systems, and interact with systemic iron homeostasis control through multiple pathways. This knowledge is crucial for preventing diseases related to iron mismanagement.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Letter
Hematology
Maria Qatato, Michael Bonadonna, Gael Palais, Alina Ertl, Gabriele Schmidt, Maria Polycarpou-Schwarz, Zoubida Karim, Bruno Galy
Article
Medicine, Research & Experimental
Joe N. Frost, Tiong Kit Tan, Munawar Abbas, Sarah K. Wideman, Michael Bonadonna, Nicole U. Stoffel, Katherine Wray, Barbara Kronsteiner, Gaby Smits, Dean R. Campagna, Tiago L. Duarte, Jose M. Lopes, Akshay Shah, Andrew E. Armitage, Joao Arezes, Pei Jin Lim, Alexandra E. Preston, David Ahern, Megan Teh, Caitlin Naylor, Mariolina Salio, Uzi Gileadi, Simon C. Andrews, Susanna J. Dunachie, Michael B. Zimmermann, Fiona R. M. van der Klis, Vincenzo Cerundolo, Oliver Bannard, Simon J. Draper, Alain R. M. Townsend, Bruno Galy, Mark D. Fleming, Marie C. Lewis, Hal Drakesmith
Summary: The study found that hypoferremia severely impairs immune responses to vaccinations, but providing extra iron can improve this situation. Experiments on mice and piglets revealed that iron deficiency weakens immunity to vaccines and pathogens.
Article
Biochemistry & Molecular Biology
Aneta Jonczy, Pawel Lipinski, Mateusz Ogorek, Rafal Radoslaw Starzynski, Daria Krzysztofik, Aleksandra Bednarz, Wojciech Krzeptowski, Mateusz Szudzik, Olga Haberkiewicz, Agnieszka Milon, Pawel Grzmil, Malgorzata Lenartowicz
Letter
Hematology
Elisabeth Tybl, Hiromi Gunshin, Sanjay Gupta, Tomasa Barrientos, Michael Bonadonna, Ferran Celma Nos, Gael Palais, Zoubida Karim, Mayka Sanchez, Nancy C. Andrews, Bruno Galy