DNA glycosylases search for and remove oxidized DNA bases

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

(2013) Silje Z. Krokeide et al.   DNA REPAIR

Structural and Biochemical Analysis of DNA Helix Invasion by the Bacterial 8-Oxoguanine DNA Glycosylase MutM

(2013) Rou-Jia Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

(2013) M. L. Hegde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Characterization of a Mouse Ortholog of Human NEIL3 with a Marked Preference for Single-Stranded DNA

(2013) Minmin Liu et al.   STRUCTURE

Base excision repair and cancer

(2012) Susan S. Wallace et al.   CANCER LETTERS

Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine

(2012) Stéphanie Duclos et al.   DNA REPAIR

Rules of engagement for base excision repair in chromatin

(2012) Ian D. Odell et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage

(2012) Minmin Liu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Thermodynamics of the multi-stage DNA lesion recognition and repair by formamidopyrimidine-DNA glycosylase using pyrrolocytosine fluorescence—stopped-flow pre-steady-state kinetics

(2012) Nikita A. Kuznetsov et al.   NUCLEIC ACIDS RESEARCH

Strandwise translocation of a DNA glycosylase on undamaged DNA

(2012) Y. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and purification of active mouse and human NEIL3 proteins

(2012) Minmin Liu et al.   PROTEIN EXPRESSION AND PURIFICATION

DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions

(2011) Karl E Zahn et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Characterization of Viral Ortholog of Human DNA Glycosylase NEIL1 Bound to Thymine Glycol or 5-Hydroxyuracil-containing DNA

(2011) Kayo Imamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome

(2011) Santi M. Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases

(2011) Yann-Vaï Le Bihan et al.   NUCLEIC ACIDS RESEARCH

Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA

(2011) Andrew R. Dunn et al.   NUCLEIC ACIDS RESEARCH

Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation

(2010) Neelam Azad et al.   Annals of the New York Academy of Sciences

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures

(2010) Corey A. Theriot et al.   DNA REPAIR

Redox regulation of Wnt signalling via nucleoredoxin

(2010) Yosuke Funato et al.   FREE RADICAL RESEARCH

Preferential Repair of Oxidized Base Damage in the Transcribed Genes of Mammalian Cells

(2010) Dibyendu Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collaborative Dynamic DNA Scanning by Nucleotide Excision Repair Proteins Investigated by Single- Molecule Imaging of Quantum-Dot-Labeled Proteins

(2010) Neil M. Kad et al.   MOLECULAR CELL

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox-control of matrix metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease

(2010) Supriya Kar et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Redox regulation of Nox proteins

(2010) Srikanth Pendyala et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reversible Chemical Step and Rate-Limiting Enzyme Regeneration in the Reaction Catalyzed by Formamidopyrimidine-DNA Glycosylase

(2009) Nikita A. Kuznetsov et al.   BIOCHEMISTRY

Expression patterns of Neil3 during embryonic brain development and neoplasia.

(2009) Gunn A Hildrestrand et al.   BMC NEUROSCIENCE

Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases

(2009) Scott D. Kathe et al.   DNA REPAIR

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

(2009) Michael K. Chan et al.   DNA REPAIR

Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance inEscherichia colimutant

(2009) Masashi Takao et al.   GENES TO CELLS

Structural Characterization of a Viral NEIL1 Ortholog Unliganded and Bound to Abasic Site-containing DNA

(2009) Kayo Imamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Entrapment and Structure of an Extrahelical Guanine Attempting to Enter the Active Site of a Bacterial DNA Glycosylase, MutM

(2009) Yan Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Real-time studies of conformational dynamics of the repair enzyme E. coli formamidopyrimidine-DNA glycosylase and its DNA complexes during catalytic cycle

(2009) Vladimir V. Koval et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme

(2009) Yan Qi et al.   NATURE

Superior Removal of Hydantoin Lesions Relative to Other Oxidized Bases by the Human DNA Glycosylase hNEIL1†

(2008) Nirmala Krishnamurthy et al.   BIOCHEMISTRY

Bacterial Base Excision Repair Enzyme Fpg Recognizes Bulky N7-Substituted-FapydG Lesion via Unproductive Binding Mode

(2008) Franck Coste et al.   CHEMISTRY & BIOLOGY

Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains

(2008) Veslemøy Rolseth et al.   DNA REPAIR

Physical and Functional Interaction between Human Oxidized Base-specific DNA Glycosylase NEIL1 and Flap Endonuclease 1

(2008) Muralidhar L. Hegde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diffusion Constant of a Nonspecifically Bound Protein Undergoing Curvilinear Motion along DNA†

(2008) Biman Bagchi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Expression and purification of NEIL3, a human DNA glycosylase homolog

(2008) Silje Z. Krokeide et al.   PROTEIN EXPRESSION AND PURIFICATION