V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells

Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles

(2015) Nora S. Kayton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Human islet distribution programme for basic research: activity over the last 5 years

(2015) Rita Nano et al.   DIABETOLOGIA

Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells

(2015) Takatsugu Yamada et al.   ENDOCRINOLOGY

Efficient Reprogramming of Human Fibroblasts and Blood-Derived Endothelial Progenitor Cells Using Nonmodified RNA for Reprogramming and Immune Evasion

(2015) Marco Alexander Poleganov et al.   HUMAN GENE THERAPY

Role of Pancreatic Transcription Factors in Maintenance of Mature β-Cell Function

(2015) Hideaki Kaneto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preserving Mafa Expression in Diabetic Islet β-Cells Improves Glycemic Controlin Vivo

(2015) Taka-aki Matsuoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAFA and T3Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC

(2015) Cristina Aguayo-Mazzucato et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Synthetic Chemically Modified mRNA-Based Delivery of Cytoprotective Factor Promotes Early Cardiomyocyte Survival Post-Acute Myocardial Infarction

(2015) Chien-Ling Huang et al.   MOLECULAR PHARMACEUTICS

Synthetic mRNAs for manipulating cellular phenotypes: an overview

(2015) Elgar Susanne Quabius et al.   New Biotechnology

Light scattering as an intrinsic indicator for pancreatic islet cell mass and secretion

(2015) E. Ilegems et al.   Scientific Reports

Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo

(2015) Alan D. Agulnick et al.   Stem Cells Translational Medicine

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reprogramming of human pancreatic exocrine cells to β-like cells

(2014) M Lemper et al.   CELL DEATH AND DIFFERENTIATION

β-Cell Differentiation of Human Pancreatic Duct–Derived Cells After In Vitro Expansion

(2014) Elisa Corritore et al.   Cellular Reprogramming

Reprogramming human umbilical cord mesenchymal stromal cells to islet-like cells with the use of in vitro –synthesized pancreatic-duodenal homebox 1 messenger RNA

(2014) Xiao Li Wang et al.   CYTOTHERAPY

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

(2014) Yan Hang et al.   DIABETES

Cell Replacement Strategies Aimed at Reconstitution of the β-Cell Compartment in Type 1 Diabetes

(2014) Giuseppe Orlando et al.   DIABETES

MafA is critical for maintenance of the mature beta cell phenotype in mice

(2014) Wataru Nishimura et al.   DIABETOLOGIA

Improved differentiation of umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells by PDX-1 mRNA transfection

(2014) Phuc Van Pham et al.   DIFFERENTIATION

The use of β-cell transcription factors in engineering artificial β cells from non-pancreatic tissue

(2014) D Gerace et al.   GENE THERAPY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

The Temporal and Hierarchical Control of Transcription Factors-Induced Liver to Pancreas Transdifferentiation

(2014) Dana Berneman-Zeitouni et al.   PLoS One

Direct Reprogramming of Human Fibroblasts to Hepatocyte-Like Cells by Synthetic Modified mRNAs

(2014) Kamen P. Simeonov et al.   PLoS One

Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb

(2014) Haruka Nagasaki et al.   PLoS One

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

(2014) Julie Piccand et al.   Cell Reports

In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes

(2014) Weida Li et al.   eLife

Making β Cells from Adult Cells Within the Pancreas

(2013) Philippe A. Lysy et al.   Current Diabetes Reports

Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA

(2013) KaiHui Hu He et al.   DEVELOPMENTAL BIOLOGY

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

PDX1 in Ducts Is Not Required for Postnatal Formation of  -Cells but Is Necessary for Their Subsequent Maturation

(2013) L. Guo et al.   DIABETES

Thyroid Hormone Promotes Postnatal Rat Pancreatic  -Cell Development and Glucose-Responsive Insulin Secretion Through MAFA

(2013) C. Aguayo-Mazzucato et al.   DIABETES

Single-cell mRNA transfection studies: Delivery, kinetics and statistics by numbers

(2013) Carolin Leonhardt et al.   Nanomedicine-Nanotechnology Biology and Medicine

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Reprogramming human fibroblasts to pluripotency using modified mRNA

(2013) Pankaj K Mandal et al.   Nature Protocols

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

RNA-Based Tools for Nuclear Reprogramming and Lineage-Conversion: Towards Clinical Applications

(2013) Juan A. Bernal   Journal of Cardiovascular Translational Research

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts

(2012) Katharina Drews et al.   BIOMATERIALS

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Pancreatic Transcription Factors Containing Protein Transduction Domains Drive Mouse Embryonic Stem Cells towards Endocrine Pancreas

(2012) Maria João Lima et al.   PLoS One

Reprogramming of pancreatic exocrine cells towards a beta (β) cell character usingPdx1,Ngn3andMafA

(2011) Ersin Akinci et al.   BIOCHEMICAL JOURNAL

Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc

(2011) Geertrui Tavernier et al.   BIOMATERIALS

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

MafA and MafB Regulate Genes Critical to  -Cells in a Unique Temporal Manner

(2010) I. Artner et al.   DIABETES

Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells

(2010) C. Aguayo-Mazzucato et al.   DIABETOLOGIA

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of MafA in pancreatic progenitors is detrimental for pancreatic development

(2009) Wataru Nishimura et al.   DEVELOPMENTAL BIOLOGY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth

(2008) A. Inada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA