Making β Cells from Adult Cells Within the Pancreas

Birth and Death of Human β-Cells in Pancreases from Cadaver Donors, Autopsies, Surgical Specimens, and Islets Transplanted into Mice

(2013) Francisco Caballero et al.   CELL TRANSPLANTATION

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

(2013) F. C. Pan et al.   DEVELOPMENT

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Adenosine Signaling Promotes Regeneration of Pancreatic β Cells In Vivo

(2012) Olov Andersson et al.   Cell Metabolism

Potential of Pluripotent Stem Cells for Diabetes Therapy

(2012) Insa S. Schroeder   Current Diabetes Reports

Epigenetic obstacles encountered by transcription factors: reprogramming against all odds

(2012) Casey A Gifford et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation

(2012) Manuel Maglione et al.   Current Opinion in Organ Transplantation

ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools

(2012) Marilia Ioannou et al.   DEVELOPMENTAL BIOLOGY

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions

(2012) A. Nakamura et al.   DIABETOLOGIA

Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the NOTCH Pathway

(2012) Yael Bar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

(2012) Cécile Jacovetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Corneal transplantation

(2012) Donald TH Tan et al.   LANCET

Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice

(2012) Rachel B. Reinert et al.   PLoS One

Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication

(2012) J. P. Annes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic regulation of pancreas development and function

(2012) Dana Avrahami et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Critical Re-Evaluation of CD24-Positivity of Human Embryonic Stem Cells Differentiated into Pancreatic Progenitors

(2012) Ortwin Naujok et al.   Stem Cell Reviews and Reports

Chemical Methods to Induce Beta-Cell Proliferation

(2012) Amedeo Vetere et al.   International Journal of Endocrinology

Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation?

(2012) Wolfgang Wagner   Stem Cell Research & Therapy

Pancreatic β-cells are generated by neogenesis from non-β-cells after birth

(2011) Korefumi Nakamura et al.   BIOMEDICAL RESEARCH-TOKYO

From hepatocytes to stem and progenitor cells for liver regenerative medicine: advances and clinical perspectives

(2011) E. M. Sokal   CELL PROLIFERATION

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin

(2011) Simon R. Smukler et al.   Cell Stem Cell

Suppression of Ptf1a Activity Induces Acinar-to-Endocrine Conversion

(2011) Daniel Hesselson et al.   CURRENT BIOLOGY

State of the Art of Clinical Islet Transplantation and Novel Protocols of Immunosuppression

(2011) A. M. James Shapiro   Current Diabetes Reports

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

(2011) Yoshifumi Saisho et al.   DIABETES

Incretin Effects on  -Cell Function, Replication, and Mass: The human perspective

(2011) A. J. Garber   DIABETES CARE

Pancreatic islet and progenitor cell surface markers with cell sorting potential

(2011) J. Hald et al.   DIABETOLOGIA

Islets Transplanted in Immunoisolation Devices: A Review of the Progress and the Challenges that Remain

(2011) Esther S. O'Sullivan et al.   ENDOCRINE REVIEWS

Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development

(2011) Maura Gasparetto et al.   EXPERIMENTAL HEMATOLOGY

Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice

(2011) Angela Criscimanna et al.   GASTROENTEROLOGY

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Insulin-Producing Cells Generated from Dedifferentiated Human Pancreatic Beta Cells Expanded In Vitro

(2011) Holger A. Russ et al.   PLoS One

Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts

(2011) Lei Tian et al.   TRANSPLANT INTERNATIONAL

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

 -Cell Growth and Regeneration: Replication Is Only Part of the Story

(2010) S. Bonner-Weir et al.   DIABETES

Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells

(2010) A. Rezania et al.   DIABETES

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

(2010) Stephen C. Hanley et al.   ENDOCRINOLOGY

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

(2010) S. Perl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation

(2010) Dawn Belt Davis et al.   MOLECULAR ENDOCRINOLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

(2010) Sameer Kassem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small-molecule inducers of insulin expression in pancreatic  -cells

(2010) D. Fomina-Yadlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta cell regeneration in human pancreas

(2010) Roberto Gianani   Seminars in Immunopathology

Controlling Destiny through Chemistry: Small-Molecule Regulators of Cell Fate

(2009) Ari J. Firestone et al.   ACS Chemical Biology

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

(2009) Dohoon Kim et al.   Cell Stem Cell

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

Gestational Diabetes Mellitus Resulting From Impaired  -Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen

(2009) H. Zhang et al.   DIABETES

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

Mesenchymal Stem Cells Derived From Human Exocrine Pancreas Express Transcription Factors Implicated in Beta-Cell Development

(2009) Reto M. Baertschiger et al.   PANCREAS

Epithelial-Mesenchymal Transition in Cells Expanded In Vitro from Lineage-Traced Adult Human Pancreatic Beta Cells

(2009) Holger A. Russ et al.   PLoS One

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

(2009) M. Rovira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

(2008) Xiaobo Xu et al.   CELL

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

In Vitro Proliferation of Cells Derived From Adult Human  -Cells Revealed By Cell-Lineage Tracing

(2008) H. A. Russ et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Impact of Small-Molecule Glucokinase Activator on Glucose Metabolism and β-Cell Mass

(2008) Akinobu Nakamura et al.   ENDOCRINOLOGY

Impaired islet turnover in human donor pancreata with aging

(2008) Christina Reers et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic β Cell Protection and Replication

(2008) Hendrik Stukenbrock et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth

(2008) A. Inada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA