Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

(2015) S. Sriskanthadevan et al.   BLOOD

Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi

(2015) Pablo Smircich et al.   BMC GENOMICS

Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles

(2015) Sabrina J. Nolan et al.   EUKARYOTIC CELL

Metabolic reconfiguration of the central glucose metabolism: a crucial strategy of Leishmania donovani for its survival during oxidative stress

(2015) Ayan K. Ghosh et al.   FASEB JOURNAL

Interfering with Immunity: Detrimental Role of Type I IFNs during Infection

(2015) Sebastian A. Stifter et al.   JOURNAL OF IMMUNOLOGY

Reevaluating the Trypanosoma cruzi proteomic map: The shotgun description of bloodstream trypomastigotes

(2015) Giselle Villa Flor Brunoro et al.   Journal of Proteomics

LACK, a RACK1 ortholog, facilitates cytochrome c oxidase subunit expression to promoteLeishmania majorfitness

(2015) Daviel Cardenas et al.   MOLECULAR MICROBIOLOGY

Trypanosoma cruzi Binds to Cytokeratin through Conserved Peptide Motifs Found in the Laminin-G-Like Domain of the gp85/Trans-sialidase Proteins

(2015) Andre Azevedo Reis Teixeira et al.   PLoS Neglected Tropical Diseases

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

(2015) Shilpi Khare et al.   PLoS Pathogens

Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

(2014) Bryan C Jensen et al.   BMC GENOMICS

The emerging role of RNA-binding proteins in the life cycle ofTrypanosoma brucei

(2014) Nikolay G. Kolev et al.   CELLULAR MICROBIOLOGY

Proteomic and Bioinformatic Analysis of Trypanosoma cruzi Chemotherapy and Potential Drug Targets: New Pieces for an Old Puzzle

(2014) Rubem Sadok Menna-Barreto et al.   CURRENT DRUG TARGETS

A Novel IFN Regulatory Factor 3-Dependent Pathway Activated by Trypanosomes Triggers IFN-  in Macrophages and Fibroblasts

(2014) A.-D. C. Chessler et al.   JOURNAL OF IMMUNOLOGY

Regulatory elements involved in the post-transcriptional control of stage-specific gene expression in Trypanosoma cruzi: a review

(2014) Patricia R Araújo et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Quantitative Proteomic and Phosphoproteomic Analysis ofTrypanosoma cruziAmastigogenesis

(2014) Rayner M. L. Queiroz et al.   MOLECULAR & CELLULAR PROTEOMICS

Networks of gene expression regulation in Trypanosoma brucei

(2014) C.E. Clayton   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A transcriptional switch underlies commitment to sexual development in malaria parasites

(2014) Björn F. C. Kafsack et al.   NATURE

Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages

(2014) Juan-José Vasquez et al.   NUCLEIC ACIDS RESEARCH

Trypanosoma cruzi: Gene Expression Surveyed by Proteomic Analysis Reveals Interaction between Different Genotypes in Mixed In Vitro Cultures

(2014) Alexandre Machin et al.   PLoS One

Proteomic Analysis of Trypanosoma cruzi Response to Ionizing Radiation Stress

(2014) Helaine Graziele Santos Vieira et al.   PLoS One

The mRNAs associated to a zinc finger protein fromTrypanosoma cruzishift during stress conditions

(2014) Lysangela Ronalte Alves et al.   RNA Biology

Deciphering RNA regulatory elements in trypanosomatids: one piece at a time or genome-wide?

(2014) Vahid H. Gazestani et al.   TRENDS IN PARASITOLOGY

Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishmania donovani

(2014) Jessica L. Martin et al.   PLoS Pathogens

Distinct genomic organization, mRNA expression and cellular localization of members of two amastin sub-families present in Trypanosoma cruzi

(2013) Monica Mendes Kangussu-Marcolino et al.   BMC MICROBIOLOGY

Host Metabolism Regulates Intracellular Growth of Trypanosoma cruzi

(2013) Kacey L. Caradonna et al.   Cell Host & Microbe

Iron uptake controls the generation ofLeishmaniainfective forms through regulation of ROS levels

(2013) Bidyottam Mittra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Apoptosis-Associated Speck-like Protein Containing a Caspase Recruitment Domain Inflammasomes Mediate IL-1  Response and Host Resistance to Trypanosoma cruzi Infection

(2013) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

Comprehensive Proteomic Analysis of Trypanosoma cruzi Epimastigote Cell Surface Proteins by Two Complementary Methods

(2013) Rayner M. L. Queiroz et al.   JOURNAL OF PROTEOME RESEARCH

Count-based differential expression analysis of RNA sequencing data using R and Bioconductor

(2013) Simon Anders et al.   Nature Protocols

Global identification of conserved post-transcriptional regulatory programs in trypanosomatids

(2013) H. S. Najafabadi et al.   NUCLEIC ACIDS RESEARCH

NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production

(2013) Virginia M. Gonçalves et al.   PLoS Neglected Tropical Diseases

The Regulation of Trypanosome Gene Expression by RNA-Binding Proteins

(2013) Christine Clayton   PLoS Pathogens

Genome-wide analysis of 3′-untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes

(2013) Javier G. De Gaudenzi et al.   PeerJ

Regulatory elements in the 3′ untranslated region of the GP82 glycoprotein are responsible for its stage-specific expression in Trypanosoma cruzi metacyclic trypomastigotes

(2012) Ethel Bayer-Santos et al.   ACTA TROPICA

A 43-Nucleotide U-rich Element in 3′-Untranslated Region of Large Number ofTrypanosoma cruziTranscripts Is Important for mRNA Abundance in Intracellular Amastigotes

(2012) Zhu-Hong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis ofTrypanosoma cruziEpimastigotes Subjected to Heat Shock

(2012) Deyanira Pérez-Morales et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Proteomic Analysis of Trypanosoma cruzi Secretome: Characterization of Two Populations of Extracellular Vesicles and Soluble Proteins

(2012) Ethel Bayer-Santos et al.   JOURNAL OF PROTEOME RESEARCH

Phospholipase A1: A novel virulence factor in Trypanosoma cruzi

(2012) María Laura Belaunzarán et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

(2012) J. S. Doggett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental Progression to Infectivity in Trypanosoma brucei Triggered by an RNA-Binding Protein

(2012) N. G. Kolev et al.   SCIENCE

Purine salvage in Leishmania: complex or simple by design?

(2012) Jan M. Boitz et al.   TRENDS IN PARASITOLOGY

Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes

(2012) S. Kelly et al.   Open Biology

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction

(2011) Herbert B. Tanowitz et al.   CELL CYCLE

Type I Interferons Increase Host Susceptibility to Trypanosoma cruzi Infection

(2011) Anne-Danielle C. Chessler et al.   INFECTION AND IMMUNITY

Requirement of UNC93B1 Reveals a Critical Role for TLR7 in Host Resistance to Primary Infection with Trypanosoma cruzi

(2011) B. C. Caetano et al.   JOURNAL OF IMMUNOLOGY

Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi

(2011) Alejandro E. Leroux et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Developmental regulation of gene expression in the absence of transcriptional control: The case of kinetoplastids

(2011) Susanne Kramer   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei

(2011) Pegine B. Walrad et al.   NUCLEIC ACIDS RESEARCH

Shotgun Sequencing Analysis of Trypanosoma cruzi I Sylvio X10/1 and Comparison with T. cruzi VI CL Brener

(2011) Oscar Franzén et al.   PLoS Neglected Tropical Diseases

Transcriptomic Signatures of Alterations in a Myoblast Cell Line Infected with Four Distinct Strains of Trypanosoma cruzi

(2010) Daniel Adesse et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Gene Network Analysis during Early Infection of Human Coronary Artery Smooth Muscle Cells by Trypanosoma cruzi and Its gp83 Ligand

(2010) Pius N. Nde et al.   CHEMISTRY & BIODIVERSITY

Flagellum assembly and function during the Leishmania life cycle

(2010) Eva Gluenz et al.   CURRENT OPINION IN MICROBIOLOGY

Optimization of endochin-like quinolones for antimalarial activity

(2010) Rolf Winter et al.   EXPERIMENTAL PARASITOLOGY

Multiple levels of gene regulation mediate differentiation of the intracellular pathogen Leishmania

(2010) T. Lahav et al.   FASEB JOURNAL

Acylation-dependent Export ofTrypanosoma cruziPhosphoinositide-specific Phospholipase C to the Outer Surface of Amastigotes

(2010) Vicente de Paulo Martins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chagas disease

(2010) Anis Rassi et al.   LANCET

Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence

(2010) Ranadhir Dey et al.   MOLECULAR MICROBIOLOGY

Role of the gp85/Trans-Sialidases in Trypanosoma cruzi Tissue Tropism: Preferential Binding of a Conserved Peptide Motif to the Vasculature In Vivo

(2010) Renata R. Tonelli et al.   PLoS Neglected Tropical Diseases

Role of GP82 in the Selective Binding to Gastric Mucin during Oral Infection with Trypanosoma cruzi

(2010) Daniela I. Staquicini et al.   PLoS Neglected Tropical Diseases

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi

(2009) Todd A Minning et al.   BMC GENOMICS

Cytokine-dependent and–independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling

(2009) Jaime A Costales et al.   BMC GENOMICS

Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons

(2009) Rafael Queiroz et al.   BMC GENOMICS

Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?

(2009) Anne M. Galea et al.   FREE RADICAL BIOLOGY AND MEDICINE

Trypanosoma cruzi Triggers an Early Type I IFN Response In Vivo at the Site of Intradermal Infection

(2009) A.-D. C. Chessler et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection

(2009) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

Glucose uptake in the mammalian stages of Trypanosoma cruzi

(2009) Ariel M. Silber et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages

(2008) V Lila Koumandou et al.   BMC GENOMICS

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

(2008) A. Cavazzuti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational modification of cellular proteins duringLeishmania donovani differentiation

(2008) Doron Rosenzweig et al.   PROTEOMICS

Antimalarial quinolones: Synthesis, potency, and mechanistic studies

(2007) Rolf W. Winter et al.   EXPERIMENTAL PARASITOLOGY