Article
Multidisciplinary Sciences
Michael B. Powner, Glen Jeffery
Summary: Systemic glucose levels can be modulated through specific solar wavelengths that affect mitochondrial metabolism. Different wavelengths of light have opposing effects on mitochondrial respiration, with longer wavelengths increasing ATP production and shorter wavelengths suppressing metabolism. This study in a bumblebee model found that manipulating mitochondrial activity with specific wavelengths of light significantly altered circulating glucose concentration. This research contributes to our understanding of how light can affect systemic metabolism.
Article
Cell Biology
Rabia Ramzan, Amalia M. Dolga, Susanne Michels, Petra Weber, Carsten Culmsee, Ardawan J. Rastan, Sebastian Vogt
Summary: This study investigates the effects of ATP inhibition on cytochrome c oxidase (CytOx) in isolated rat heart mitochondria. The findings suggest that inhibiting CytOx activity with ATP leads to static respiration and decreased ROS production, highlighting the importance of ATP/ADP ratio for mitochondrial function.
Article
Chemistry, Multidisciplinary
Wenshu Cong, Li Meng, Yuanjie Pan, Han Wang, Jiahui Zhu, Yuanyu Huang, Qingli Huang
Summary: Population aging is a global issue, and this study presents a novel approach using Pd-based single-atom nanozymes to improve mitochondrial function and attenuate aging. The nanozyme mimics enzyme activities in the mitochondrial respiratory chain and enhances mitochondrial activities and abundance. Additionally, it demonstrates excellent anti-aging and neuroprotective effects through the activation of the mitochondrial unfolded protein response (UPRmt) pathway.
Review
Microbiology
Eleanor C. Saunders, Marijke F. Sernee, Julie E. Ralton, Malcolm J. McConville
Summary: Leishmania parasites can survive long-term in the mature phagolysosome compartment of host cells by switching to a slow growth state and activating a stringent metabolic response. The heterogeneous expression of this response in vivo reflects temporal and spatial differences in lesion tissues, including dormant stages.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Aprajita Kumari, Vemula Chandra Kaladhar, Nidhi Yadav, Pooja Singh, Kishorekumar Reddy, Kapuganti Jagadis Gupta
Summary: The location of NO production in mitochondrial cytochrome c oxidase and its role in mitochondrial biogenesis were investigated in Arabidopsis seedlings under osmotic stress and recovery. Osmotic stress reduced growth and mitochondrial number while increasing NO production. Nitrite application stimulated NO production and mitochondrial number in a NO-deficient mutant. COX6b(-)3 and COA6-L subunits were induced during osmotic stress and mutants impaired in these subunits showed reduced NO production and mitochondrial biogenesis. The COX6b-3 and COA6-L subunits interacted with a VQ27 motif-containing protein in the presence of NO, and a vq27 mutant displayed impaired mitochondrial biogenesis.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Veterinary Sciences
Steven V. Kubiski, Carmel Witte, Jennifer A. Burchell, Dylan Conradson, Alexandra Zmuda, Alberto Rodriguez Barbon, Jose G. Vilches-Moure, Stephen A. Felt, Bruce A. Rideout
Summary: Isospora infections are common in both wild and captive passerine species. The severity of the disease varies, making it a concern for institutions housing endangered species. The risk of severe isosporiasis due to mixed-species enclosures and non-host-adapted strains needs further research.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Neurosciences
Benjamin R. Troutwine, Taylor A. Strope, Edziu Franczak, Colton R. Lysaker, Laylan Hamid, Clayton Mansel, Julia A. Stopperan, Cynthia M. Gouvion, Mohammad Haeri, Russell H. Swerdlow, Heather M. Wilkins
Summary: The study found that Alzheimer's disease (AD) patients have mitochondrial dysfunction, specifically reduced brain cytochrome oxidase (COX) function and complex II Vmax. APOE epsilon 4 carriers also have deficits in COX, complex II, and III. These results suggest a dysregulated relationship between brain mitochondrial function and A beta pathology in AD.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Cell Biology
Bettina Homberg, Peter Rehling, Luis Daniel Cruz-Zaragoza
Summary: Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria by protein translocases. The oxidase assembly (OXA) insertase in mitochondria plays a role in inserting mitochondrial-encoded proteins into the inner membrane. Recent research reveals the cooperation between OXA and the mitochondrial ribosome during the synthesis of these proteins, suggesting that OXA is a multifunctional protein insertase involved in protein transport, assembly, and stability at the inner membrane.
TRENDS IN CELL BIOLOGY
(2023)
Article
Cell Biology
Rosalinda C. Roberts
Summary: Schizophrenia is associated with abnormalities in mitochondrial structure and function, with deficits in mitochondrial gene expression, oxidative stress, energy metabolism, and synaptic function. These abnormalities may contribute to the symptoms and pathology of the disease.
Review
Cell Biology
Bernhard Kadenbach
Summary: ATP serves as the universal energy currency in all living cells, mainly synthesized in mitochondria through oxidative phosphorylation. Cytochrome c oxidase (COX) acts as the regulatory center of OXPHOS, regulated by various effectors such as feedback inhibition by ATP and phosphorylation. In the relaxed state, ATP inhibition of phosphorylated and dimeric COX helps maintain a low and healthy mitochondrial membrane potential, preventing the formation of ROS.
Article
Environmental Sciences
Libing Yu, Wenjing Li, Jian Chu, Chun Chen, Xijian Li, Wei Tang, Binyuan Xia, Zhonghua Xiong
Summary: Uranium as an emerging pollutant presents serious threats to ecological and human health, with the kidney identified as a major deposition site and sensitive target organ for its toxicity, which is associated with oxidative stress and mitochondrial respiration. This study found that cytochrome c oxidase and ATP synthase play key roles in uranium-induced toxicity by inhibiting their activities in the mitochondrial respiration pathway. These inhibitory effects could explain the generation of reactive oxygen species and mitochondrial alterations observed in uranium poisoning.
ENVIRONMENTAL POLLUTION
(2021)
Article
Immunology
Christine Matte, Guillermo Arango Duque, Albert Descoteaux
Summary: Leishmaniasis, caused by protozoan parasites, can have debilitating effects ranging from self-healing ulcers to life-threatening visceral pathologies. Research has shown that early-stage interactions between Leishmania and inflammatory monocytes can impact antimicrobial responses, with the parasites inhibiting microbicidal properties of phagosomes within the cells. This study found that Leishmania donovani metacyclic promastigotes can impair superoxide production and pH acidification within inflammatory monocytes, potentially contributing to the establishment of chronic disease.
INFECTION AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Lynne M. Christianson, Shannon B. Johnson, Darrin T. Schultz, Steven H. D. Haddock
Summary: Despite historical difficulties in studying ctenophores, new primers have successfully amplified COI fragments, highlighting high diversity and supporting ecological and morphological differences among species. These new tools provide important advancements for researchers in exploring ctenophore diversity on a global scale.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Multidisciplinary Sciences
Jinsong Wei, Shuai Wang, Haozhe Zhu, Wei Cui, Jianan Gao, Ce Gao, Bo Yu, Bojing Liu, Jun Chen, Jinrong Peng
Summary: The study reveals that the nucleolar protein degradation pathway, mDEF-CAPN3, regulates the mitochondrial copper homeostasis by influencing the localization and accumulation of CAPN3, p53, and NRF1 proteins in the nucleoli, leading to the enhanced expression of Sco2 and Cox genes in the mitochondria, which promotes copper acquisition.
Article
Multidisciplinary Sciences
Luke E. Formosa, Shadi Maghool, Alice J. Sharpe, Boris Reljic, Linden Muellner-Wong, David A. Stroud, Michael T. Ryan, Megan J. Maher
Summary: COA7 is a crucial assembly factor for the biogenesis of mitochondrial complex IV. It interacts with SCO1 and SCO2 to catalyze copper relay and reduction of disulfide bonds, which are important for complex IV assembly.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Public, Environmental & Occupational Health
V. Ramesh, Himanshu Kaushal, Ashwani Kumar Mishra, Ruchi Singh, Poonam Salotra
Review
Pathology
Robert Duncan, Moussa Kourout, Elena Grigorenko, Carolyn Fisher, Ming Dong
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2016)
Article
Biochemistry & Molecular Biology
Vanila Sharma, Paresh Sharma, Angamuthu Selvapandiyan, Poonam Salotra
MOLECULAR MICROBIOLOGY
(2016)
Article
Infectious Diseases
V. Ramesh, Ruchi Singh, Kumar Avishek, Aditya Verma, Deepak Kumar Deep, Sandeep Verma, Poonam Salotra
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Article
Immunology
H. Kaushal, R. Bras-Goncalves, K. Avishek, D. Kumar Deep, E. Petitdidier, J. -L. Lemesre, G. Papierok, S. Kumar, V. Ramesh, P. Salotra
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
M. Dong, C. Fisher, G. Anez, M. Rios, H. L. Nakhasi, J. P. Hobson, M. Beanan, D. Hockman, E. Grigorenko, R. Duncan
JOURNAL OF APPLIED MICROBIOLOGY
(2016)
Editorial Material
Dermatology
V. Ramesh, Kumar Avishek, Poonam Salotra
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2015)
Article
Pathology
Elena Grigorenko, Carolyn Fisher, Sunali Patel, Caren Chancey, Maria Rios, Hira L. Nakhasi, Robert C. Duncan
JOURNAL OF MOLECULAR DIAGNOSTICS
(2014)
Editorial Material
Pathology
Robert Duncan
JOURNAL OF MOLECULAR DIAGNOSTICS
(2014)
Article
Parasitology
Lena Krayter, Ram A. Bumb, Kifaya Azmi, Julia Wuttke, Mariam D. Malik, Lionel F. Schnur, Poonam Salotra, Gabriele Schoenian
PARASITES & VECTORS
(2014)
Article
Multidisciplinary Sciences
Kumar Avishek, Himanshu Kaushal, Sreenivas Gannavaram, Ranadhir Dey, Angamuthu Selvapandiyan, V. Ramesh, Narender Singh Negi, Uma S. Dubey, Hira L. Nakhasi, Poonam Salotra
SCIENTIFIC REPORTS
(2016)
Review
Pathology
Robert Duncan, Elena Grigorenko, Carolyn Fisher, Donna Hockman, Bryan Lanning
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2019)
Article
Biotechnology & Applied Microbiology
R. A. Multari, D. A. Cremers, A. Nelson, Z. Karimi, S. Young, C. Fisher, R. Duncan
JOURNAL OF APPLIED MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Irina Tiper, Moussa Kourout, Carolyn Fisher, Krishnamurthy Konduru, Anjan Purkayastha, Gerardo Kaplan, Robert Duncan
Summary: Filoviruses are emerging pathogens causing acute fever with high fatality rates, posing a global public health threat. Genome sequencing during the Ebola virus outbreak enabled the study of virus evolution, pathogenic mutations, and viral spread. Resequencing microarrays provide a targeted, rapid, and sensitive method for obtaining genomic sequences critical in studying Ebolaviruses.
Article
Infectious Diseases
Sandeep Verma, Ruchi Singh, Vanila Sharma, Ram Avtar Bumb, Narendra Singh Negi, V. Ramesh, Poonam Salotra
BMC INFECTIOUS DISEASES
(2017)