Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

Recent Clinical Trials for the Etiological Treatment of Chronic Chagas Disease: Advances, Challenges and Perspectives

(2014) Julio A. Urbina   JOURNAL OF EUKARYOTIC MICROBIOLOGY

4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

(2014) Claudia M. Calvet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis

(2014) et al.   SCIENCE

Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents

(2013) Daryl L. Richie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

(2013) Jonathan W Choy et al.   Beilstein Journal of Organic Chemistry

New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice

(2013) J. M. Bustamante et al.   JOURNAL OF INFECTIOUS DISEASES

Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas Agents

(2013) Jun Yong Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

(2013) Grasiella Andriani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations

(2013) Gregory I. Lang et al.   NATURE

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

(2013) S. P. S. Rao et al.   Science Translational Medicine

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

(2012) Dominic Hoepfner et al.   Cell Host & Microbe

Drug delivery systems for the topical treatment of cutaneous leishmaniasis

(2012) Guilherme Carneiro et al.   Expert Opinion on Drug Delivery

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

(2012) Marco Spinazzi et al.   Nature Protocols

Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

(2012) Beat Nyfeler et al.   PLoS One

Multiple Mitochondrial Introgression Events and Heteroplasmy in Trypanosoma cruzi Revealed by Maxicircle MLST and Next Generation Sequencing

(2012) Louisa A. Messenger et al.   PLoS Neglected Tropical Diseases

A Chemical Genomic Analysis of Decoquinate, aPlasmodium falciparumCytochromebInhibitor

(2011) Tae-gyu Nam et al.   ACS Chemical Biology

X-ray structure of the dimeric cytochrome bc1 complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution

(2011) Thomas Kleinschroth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Trypanosoma cruzi and Chagas' Disease in the United States

(2011) C. Bern et al.   CLINICAL MICROBIOLOGY REVIEWS

Finding New Hits in Neglected Disease Projects: Target or Phenotypic Based Screening?

(2011) Ian H. Gilbert et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Variation among Plasmodium falciparum Strains in Their Reliance on Mitochondrial Electron Transport Chain Function

(2011) Hangjun Ke et al.   EUKARYOTIC CELL

O2 consumption rates along the growth curve: new insights into Trypanosoma cruzi mitochondrial respiratory chain

(2011) Thiago M. Silva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Role of Trypanosoma cruzi peroxiredoxins in mitochondrial bioenergetics

(2011) Eduardo de Figueiredo Peloso et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Saccharomyces Genome Database: the genomics resource of budding yeast

(2011) J. M. Cherry et al.   NUCLEIC ACIDS RESEARCH

The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

(2011) Rosario Diaz-Gonzalez et al.   PLoS Neglected Tropical Diseases

Successful Treatment with Posaconazole of a Patient with Chronic Chagas Disease and Systemic Lupus Erythematosus

(2010) María-Jesús Pinazo et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

(2010) J. C. Engel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Advances in Chagas disease drug development: 2009–2010

(2010) Frederick S Buckner et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Decylubiquinone Increases Mitochondrial Function in Synaptosomes

(2010) Jayne E. Telford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chagas disease

(2010) Anis Rassi et al.   LANCET

A population of tRNA-derived small RNAs is actively produced in Trypanosoma cruzi and recruited to specific cytoplasmic granules

(2010) Maria Rosa Garcia-Silva et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Chagas disease: pushing through the pipeline

(2010) Julie Clayton   NATURE

A survey of yeast genomic assays for drug and target discovery

(2010) Andrew M. Smith et al.   PHARMACOLOGY & THERAPEUTICS

Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities

(2009) Rodolfo Viotti et al.   Expert Review of Anti-Infective Therapy

Use of L-Proline and ATP Production by Trypanosoma cruzi Metacyclic Forms as Requirements for Host Cell Invasion

(2009) R. M. Martins et al.   INFECTION AND IMMUNITY

Two approaches to discovering and developing new drugs for Chagas disease

(2009) JH McKerrow et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Molecular basis of resistance to cytochromebc1inhibitors

(2008) Nick Fisher et al.   FEMS YEAST RESEARCH

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA