Targeting endoplasmic reticulum stress in liver disease

CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis

(2016) Erawan Borkham-Kamphorst et al.   CELLULAR SIGNALLING

Endoplasmic reticulum stress and disturbed calcium homeostasis are involved in copper-induced alteration in hepatic lipid metabolism in yellow catfish Pelteobagrus fulvidraco

(2016) Yu-Feng Song et al.   CHEMOSPHERE

PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1

(2016) Daniela Eletto et al.   FASEB JOURNAL

Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway

(2016) Ru Ying et al.   LIFE SCIENCES

Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress

(2015) J. D. Mosinski et al.   Acta Physiologica

Tauroursodeoxycholic acid prevents stress induced aggregation of proteins in vitro and promotes PERK activation in HepG2 cells

(2015) Amina R. Gani et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68

(2015) Tsz Yan Wong et al.   BRITISH JOURNAL OF NUTRITION

Synthesis and biological evaluation of geldanamycin analogs against human cancer cells

(2015) Yan-ping Li et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

(2015) Z. Lin et al.   CIRCULATION

5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma

(2015) Xiao-Yun Hu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(ii)(salicylaldiminato)(DMSO or Picolino)Cl complexes

(2015) Faiz-Ur Rahman et al.   DALTON TRANSACTIONS

Baicalein protects against polymicrobial sepsis-induced liver injury via inhibition of inflammation and apoptosis in mice

(2015) Anding Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms

(2015) Jung-Ju Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cystatin C attenuates insulin signaling transduction by promoting endoplasmic reticulum stress in hepatocytes

(2015) Xiaolin Ji et al.   FEBS LETTERS

Dysregulated iron homeostasis is strongly associated with multiorgan failure and early mortality in acute-on-chronic liver failure

(2015) Jaswinder Singh Maras et al.   HEPATOLOGY

Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress

(2015) Min-Kyung Jang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis

(2015) Motoko Sasaki et al.   JOURNAL OF GASTROENTEROLOGY

Selective Regulation of FGF19 and FGF21 Expression by Cellular and Nutritional Stress

(2015) Makoto SHIMIZU et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis

(2015) Beatriz San-Miguel et al.   JOURNAL OF PINEAL RESEARCH

Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice

(2015) Kyung Eun Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Fenofibrate Treatment Attenuated Chronic Endoplasmic Reticulum Stress in the Liver of Nonalcoholic Fatty Liver Disease Mice

(2015) Nan Zhang et al.   PHARMACOLOGY

Baicalein Triggers Autophagy and Inhibits the Protein Kinase B/Mammalian Target of Rapamycin Pathway in Hepatocellular Carcinoma HepG2 Cells

(2015) Ya-Fang Wang et al.   PHYTOTHERAPY RESEARCH

Genomewide Histone H3 Lysine 9 Acetylation Profiling in CD4+ T Cells Revealed Endoplasmic Reticulum Stress Deficiency in Patients with Acute-on-chronic Liver Failure

(2015) L. Jin et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Rapamycin Protection of Livers From Ischemia and Reperfusion Injury Is Dependent on Both Autophagy Induction and Mammalian Target of Rapamycin Complex 2-Akt Activation

(2015) Jianjun Zhu et al.   TRANSPLANTATION

Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

(2015) Behzad Yeganeh   WORLD JOURNAL OF GASTROENTEROLOGY

Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress

(2015) Jian-Shuang Li et al.   Food & Function

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

(2015) Yves-Paul Vandewynckel et al.   Oncotarget

Erratum: Corrigendum: Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice

(2015) Jingyao Zhang et al.   Scientific Reports

Autophagy in ethanol-exposed liver disease

(2015) Li-Ren Wang et al.   Expert Review of Gastroenterology & Hepatology

The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease

(2015) Alexandra Feldman et al.   Biomed Research International

The Hsp90 inhibitor SNX-2112 induces apoptosis of human hepatocellular carcinoma cells: The role of ER stress

(2014) Xiao Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Tauroursodeoxycholic Acid Attenuates Progression of Steatohepatitis in Mice Fed a Methionine–Choline-Deficient Diet

(2014) Eun-Ju Cho et al.   DIGESTIVE DISEASES AND SCIENCES

Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress

(2014) Jeong Moon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Involvement of androgen receptor and glucose-regulated protein 78kDa in human hepatocarcinogenesis

(2014) Xia Jiang et al.   EXPERIMENTAL CELL RESEARCH

The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target

(2014) Wen-Yue Liu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target

(2014) Wen-Yue Liu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

(2014) Shan Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of Cyclophilins B and C Leads to Dysregulation of Endoplasmic Reticulum Redox Homeostasis

(2014) Pawel Stocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phagocytic function of Kupffer cells in mouse nonalcoholic fatty liver disease models: Evaluation with superparamagnetic iron oxide

(2014) Hyunhee Cheong et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Resveratrol Enhances Palmitate-Induced ER Stress and Apoptosis in Cancer Cells

(2014) Cristina Rojas et al.   PLoS One

Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity

(2014) Wim F.P.M. Van den Hof et al.   TOXICOLOGY

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

(2014) Mario Sanches et al.   Nature Communications

Autophagy in HCV Infection: Keeping Fat and Inflammation at Bay

(2014) Tiziana Vescovo et al.   Biomed Research International

The involvement of endoplasmic reticulum stress in bile acid-induced hepatocellular injury

(2013) Tetsuo Adachi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

(2013) Virginia Hernández-Gea et al.   JOURNAL OF HEPATOLOGY

Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway

(2013) Yi-Jen Chen et al.   MOLECULES

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia/reperfusion in mouse livers

(2013) Jae-Sung Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ultrastructural Examination of Renal Tubular Epithelial Cells and Hepatocytes in the Course of Chronic Cyclosporin A Treatment—A Possible Link to Oxidative Stress

(2013) Agnieszka Korolczuk et al.   ULTRASTRUCTURAL PATHOLOGY

Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity

(2013) Juan Yang et al.   Food & Function

Insulin Resistance, Ceramide Accumulation and Endoplasmic Reticulum Stress in Experimental Chronic Alcohol-Induced Steatohepatitis

(2012) Teresa Ramirez et al.   ALCOHOL AND ALCOHOLISM

Autophagy and RNA virus interactomes reveal IRGM as a common target

(2012) Isabel Pombo Grégoire et al.   Autophagy

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

(2012) Kenneth Cusi   GASTROENTEROLOGY

Replication of Hepatitis C Virus RNA on Autophagosomal Membranes

(2012) Donna Sir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice

(2012) Tomohiro Nakanishi et al.   JOURNAL OF NEUROCHEMISTRY

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease

(2012) Lisa Longato et al.   Oxidative Medicine and Cellular Longevity

Alcohol Disrupts Endoplasmic Reticulum Function and Protein Secretion in Hepatocytes

(2011) Deanna L. Howarth et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

4-Phenylbutyrate Stimulates Hsp70 Expression through the Elp2 Component of Elongator and STAT-3 in Cystic Fibrosis Epithelial Cells

(2011) Laurence Suaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease

(2011) Kori Volkmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways

(2011) Ting-Fang Kuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Hepatic Fibrosis and Carcinogenesis in  1-Antitrypsin Deficiency: A Prototype for Chronic Tissue Damage in Gain-of-Function Disorders

(2011) D. H. Perlmutter et al.   Cold Spring Harbor Perspectives in Biology

Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis

(2011) M P Lim et al.   Cell Death & Disease

Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells

(2010) Zeng-si Wang et al.   ACTA PHARMACOLOGICA SINICA

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction

(2010) Ji Hyun Choi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes

(2010) Shubham Shrivastava et al.   HEPATOLOGY

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

The Role of Lipid Metabolism in the Pathogenesis of Alcoholic and Nonalcoholic Hepatic Steatosis

(2010) Margaret Sozio et al.   SEMINARS IN LIVER DISEASE

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Knockdown of autophagy-related gene decreases the production of infectious Hepatitis C virus particles

(2009) Isei Tanida et al.   Autophagy

HIV protease inhibitor lopinavir-induced TNF-α and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages

(2009) Li Chen et al.   BIOCHEMICAL PHARMACOLOGY

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

(2009) L. P. James et al.   DRUG METABOLISM AND DISPOSITION

Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

(2009) Daisuke Oikawa et al.   EXPERIMENTAL CELL RESEARCH

A Novel Endoplasmic Reticulum Export Signal

(2009) Yoshinori Tsukumo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis

(2009) Shin-ichiro Hino et al.   JOURNAL OF BONE AND MINERAL METABOLISM

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

The Protective Effect of a Newly Developed Molecular Chaperone–Inducer Against Mouse Ischemic Acute Kidney Injury

(2009) Worapat Prachasilchai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The autophagy machinery is required to initiate hepatitis C virus replication

(2009) M. Dreux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury

(2009) Gábor Nagy et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury

(2008) Nobuyuki Tamaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Protein quality control in the early secretory pathway

(2008) Tiziana Anelli et al.   EMBO JOURNAL

Mammalian BiP controls posttranslational ER translocation of the hepatitis B virus large envelope protein

(2008) Karin Awe et al.   FEBS LETTERS

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response

(2008) Donna Sir et al.   HEPATOLOGY

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

(2008) InKi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress

(2008) Irina M Bochkis et al.   NATURE MEDICINE

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

(2008) E. Bobrovnikova-Marjon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice

(2007) Kazutomi Yoshiuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY