Article
Nutrition & Dietetics
Nouf Aljobaily, Kelsey Krutsinger, Michael J. Viereckl, Raznin Joly, Bridger Menlove, Brexton Cone, Ailaina Suppes, Yuyan Han
Summary: This study demonstrates the therapeutic potential of cannabigerol (CBG), a plant-derived non-psychotropic compound, in reducing hepatic steatosis, fibrosis, and inflammation in Non-Alcoholic Steatohepatitis (NASH). The low dose of CBG alleviated hepatic fibrosis and inflammation, while the high dose of CBG showed enhanced liver damage.
Article
Gastroenterology & Hepatology
Yu Jung Heo, Sung-E Choi, Nami Lee, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim
Summary: Visfatin injection aggravated hepatic steatosis, inflammation, and fibrosis in the MCD-diet-induced steatohepatitis mouse model by inducing ER and oxidative stress.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Endocrinology & Metabolism
Shuquan Lv, Zhongyong Zhang, Xiuhai Su, Wendong Li, Xiaoyun Wang, Baochao Pan, Hanzhou Li, Hui Zhang, Yuansong Wang
Summary: Qingrequzhuo capsule (QRQZ), composed of various plant extracts, has been used to treat nonalcoholic steatohepatitis (NASH). This study found that QRQZ reduced lipid accumulation and inflammation in NASH mice by modulating gut microbiota, enhancing gut barrier function, and inhibiting TLR4/NF-kB signaling pathway activation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Wei Wang, Ting Zhai, Ping Luo, Xiaolei Miao, Junjun Wang, Yong Chen
Summary: The study showed that SIL treatment reduced serum lipids and bile acid levels in MCD mice, while increasing beneficial microorganisms. This alleviative effect may be achieved by influencing the composition of the gut microbiota and regulating the levels of serum lipids and bile acids through the enterohepatic axis.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Reyes Gamez-Belmonte, Mireia Tena-Garitaonaindia, Cristina Hernandez-Chirlaque, Samir Cordova, Diego Ceacero-Heras, Fermin Sanchez de Medina, Olga Martinez-Augustin
Summary: The study showed that TNAP haplodeficient mice can develop hepatosteatosis similar to that induced by a MCD diet when fed a control diet, but without weight loss, increased ALT levels, or hypoglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Meng-juan Gong, Cai-yan Zhu, Zhong-jie Zou, Bin Han, Ping Huang
Summary: The study evaluated the beneficial effects and underlying mechanisms of puerarin on MCD diet-induced NASH in mice using metabonomics and gene sequencing. Puerarin improved hepatic steatosis and inflammation in NASH mice by ameliorating metabolic disorders and rebalancing gut flora. The findings provide new insights into NASH pathogenesis and support the use of puerarin as an anti-NASH agent.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Gastroenterology & Hepatology
Martin Karl, Solveig Hasselwander, Yawen Zhou, Gisela Reifenberg, Yong Ook Kim, Kyoung-Sook Park, Dirk A. Ridder, Xiaoyu Wang, Eric Seidel, Nadine Hoevelmeyer, Beate K. Straub, Huige Li, Detlef Schuppan, Ning Xia
Summary: This study suggests that B lymphocytes play both detrimental and protective roles in the development of non-alcoholic fatty liver disease (NAFLD). The lack of secretion of pathogenic antibodies partially protects from NAFLD, while certain subsets of B cells provide additional protection. Regulatory B cells producing IL-10 may represent a protective subset of B cells.
Article
Food Science & Technology
Xinwei Jiang, Xia Li, Wenjun Feng, Yige Qin, Zhen Li, Hua Nie, Weibing Qin, Lu Han, Weibin Bai
Summary: This study demonstrates the importance of methionine and choline in diet and emphasizes the crucial role of cooking conditions, which are dietary factors that influence the quality of sperm production. The results showed that a methionine-choline deficient diet induced testicular degradation and damage to spermatocytes, while baking the diet further aggravated testicular injury and significantly reduced sperm density, motility, and normal sperm morphology. These effects were not related to the blood-testis barrier or Leydig cell dysfunction, but were associated with spermatocyte loss and apoptosis mediated by endoplasmic reticulum stress.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bilian Zhu, Honggui Li, Bangchao Lu, Xinlei Guo, Chiashan Wu, Fen Wang, Qingsheng Li, Linglin Xie, Shannon Glaser, Heather Francis, Gianfranco Alpini, Chaodong Wu
Summary: Indole supplementation alleviates the severity of non-alcoholic steatohepatitis (NASH) by suppressing hepatocyte proinflammatory responses and hepatic stellate cell fibrogenic activation, as well as reducing intestinal proinflammatory responses.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Editorial Material
Gastroenterology & Hepatology
Manal F. Abdelmalek
Summary: In 2020, there were significant advances in nonalcoholic fatty liver disease, including new insights into pathophysiology, advancements in non-invasive diagnostics, and the publication of interim results from the first phase III trial showing improvement in hepatic fibrosis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Microbiology
An-Ming Yang, Chien-Yu Lin, Shih-Hao Liu, Guan-Da Syu, Hao-Jhe Sun, Kuei-Chuan Lee, Han-Chieh Lin, Ming-Chih Hou
Summary: Saccharomyces boulardii (SB), a dietary supplement yeast, has been shown to improve non-alcoholic steatohepatitis (NASH) symptoms by maintaining gut integrity, increasing microbial diversity, and increasing the number of potentially beneficial gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammed Abdullah Alshawsh, Abdulsamad Alsalahi, Salah Abdalrazak Alshehade, Sultan Ayesh Mohammed Saghir, Ahmad Faheem Ahmeda, Raghdaa Hamdan Al Zarzour, Ayman Moawad Mahmoud
Summary: This review evaluates the differences in gene expression patterns and NAFLD/NASH progression pathways between two common dietary animal models, HFD-fed and MCD diet-fed animals. The study shows that both HFD and MCD diet can regulate the expression of genes and proteins involved in lipid metabolism, inflammation, oxidative stress, and fibrogenesis pathways. The MCD diet model can spontaneously develop liver fibrosis within a short period of time, while the HFD model shows milder fibrosis.
Article
Biochemistry & Molecular Biology
Mariana Silva Thomaz, Marcela Nascimento Sertorio, Marcos Leoni Gazarini, Daniel Araki Ribeiro, Luciana Pellegrini Pisani, Marcia Regina Nagaoka
Summary: Non-alcoholic fatty liver is the leading cause of liver disease worldwide. This study investigated the role of kinins in experimental non-alcoholic steatohepatitis (NASH) and found that kinins affect the antioxidant system and reduce superoxide dismutase activity in NASH.
Article
Medicine, Research & Experimental
Baohuan Lian, Lijun Cai, Zhaoqiang Zhang, Fen Lin, Zongxi Li, Xiao-kun Zhang, Fuquan Jiang
Summary: This study investigated the effects of Pien Tze Huang (PTH) on NASH mouse models and found that it exerted hepatoprotective effects by improving liver weight, reducing steatosis and fibrosis, and lowering serum levels of ALT and AST. PTH also inhibited the activation of the inflammatory pathway NF-κB, contributing to the improvement of NAFLD.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Youngae Jung, Bo Kyung Koo, Seo Young Jang, Dain Kim, Heeyeon Lee, Dong Hyeon Lee, Sae Kyung Joo, Yong Jin Jung, Jeong Hwan Park, Taekyeong Yoo, Murim Choi, Min Kyung Lee, Sang Won Kang, Mee Soo Chang, Won Kim, Geum-Sook Hwang
Summary: This study found that bile acid metabolism is dysregulated as the histological severity of NAFLD worsens, independent of obesity and diabetes status, and more prominent in nonobese NAFLD patients. The metabolome-driven omics approach provides new insight into altered bile acid metabolism associated with individual phenotypes of NAFLD.
LIVER INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Xianhua Mao, Ka Shing Cheung, Chengzhi Peng, Lung-Yi Mak, Ho Ming Cheng, James Fung, Noam Peleg, Howard H-W Leung, Rajneesh Kumar, Jeong-Hoon Lee, Amir Shlomai, Man-Fung Yuen, Wai-Kay Seto
Summary: This study collected data from observational studies to investigate the association of hepatic steatosis with HCC, cirrhosis, fibrosis, and HBsAg seroclearance. The results showed that hepatic steatosis was associated with an increased risk of HCC and cirrhosis among patients with CHB, but it also increased the chance of achieving a functional cure.
Article
Biochemistry & Molecular Biology
Su Jong Yu, Jeong-Ju Yoo, Dong Ho Lee, Su Jin Kim, Eun Ju Cho, Se Hyung Kim, Jeong-Hoon Lee, Yoon Jun Kim, Jeong Min Lee, Jae Young Lee, Jung-Hwan Yoon
Summary: Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced MRI can detect early stages of hepatocellular carcinoma (HCC) in patients with cirrhosis, but its survival benefit is unknown. This retrospective cohort study found that intermittent replacement of ultrasonography (USG) with Gd-EOB-DTPA-enhanced MRI improved the clinical outcomes of cirrhosis patients, including overall survival and time to progression.
Article
Radiology, Nuclear Medicine & Medical Imaging
Min Kyung Park, Dong Ho Lee, Bo Yun Hur, Hyung-Chul Lee, Yun Bin Lee, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee
Summary: This study assessed the detection power of ultrasound (US) and the occurrence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) based on the US Liver Imaging Reporting and Data System (LI-RADS) visualization score. The results showed that patients with suboptimal visualization (score B or C) had a higher risk of HCC and a higher rate of false-negative findings on US.
Article
Medicine, General & Internal
Eun Ju Cho, Goh Eun Chung, Jeong-Ju Yoo, Yuri Cho, Dong Wook Shin, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Su Jong Yu
Summary: This study aimed to investigate whether the association between alcohol consumption and hepatocellular carcinoma (HCC) risk differs by fasting serum glucose level and diabetes. The results showed that mild-to-moderate alcohol consumption increased the risk of HCC in all glycemic statuses, but the risk was highest in patients with diabetes.
Article
Medicine, General & Internal
Jeong-Ju Yoo, Man Young Park, Eun Ju Cho, Su Jong Yu, Sang Gyune Kim, Yoon Jun Kim, Young Seok Kim, Jung-Hwan Yoon
Summary: This study investigates the effect of smoking on the incidence of hepatocellular carcinoma (HCC) and cardiovascular disease (CVD) in patients with metabolic-associated fatty liver disease (MAFLD). The analysis of a Korean health screening database shows that smoking significantly increases the risk of HCC and CVD in MAFLD patients. Complete smoking cessation is highly recommended for individuals with MAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jihye Kim, Moon Haeng Hur, Seung Up Kim, Jin-Wook Kim, Dong Hyun Sinn, Hyun Woong Lee, Moon Young Kim, Jae Youn Cheong, Yong Jin Jung, Han Ah Lee, Young-Joo Jin, Jun Sik Yoon, Sung-Jae Park, Chang Hun Lee, In Hee Kim, June Sung Lee, Young Youn Cho, Hyung Joon Kim, Soo Young Park, Yeon Seok Seo, Hyunwoo Oh, Dae Won Jun, Mi Na Kim, Young Chang, Jae Young Jang, Sang Youn Hwang, Yoon Jun Kim
Summary: This study compared the effectiveness of entecavir and tenofovir disoproxil fumarate in preventing hepatocellular carcinoma among patients with chronic hepatitis B. The study found that the two antivirals had similar efficacy in preventing HCC and had comparable rates of other outcomes. However, the tenofovir disoproxil fumarate group had more side effects, leading to some patients needing to switch initial antiviral medications.
Article
Oncology
Goh Eun Chung, Su Jong Yu, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Dong Wook Shin, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Eun Ju Cho
Summary: This study investigates the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and cancer incidence or mortality. By categorizing MAFLD subgroups based on additional etiologies, the study found differential risks of all- and site-specific cancer incidence and mortality. These findings highlight the importance of MAFLD classification in identifying patients with poor cancer-related outcomes.
CANCER COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Cheol-Hyung Lee, Yun Bin Lee, Hyemi Moon, Jong-Won Chung, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Juneyoung Lee, Jung-Hwan Yoon
Summary: This study investigated the associations between aspirin use and risks of hepatocellular carcinoma (HCC), liver-related mortality, and major bleeding in non-cirrhotic patients with chronic hepatitis B (CHB). The results showed that aspirin use was associated with reduced risks of HCC and liver-related death, without an increase in the risk of major bleeding, in patients with CHB and a higher metabolic risk factor burden.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Scott K. Fung, Calvin Q. Pan, Grace Lai-Hung Wong, Wai-Kay Seto, Sang Hoon Ahn, Chi-Yi Chen, Hie-Won L. Hann, Maciej S. Jablkowski, Yoon Jun Kim, Cihan Yurdaydin, Cheng-Yuan Peng, Tuan Nguyen, Hiroshi Yatsuhashi, John F. Flaherty, Leland J. Yee, Frida Abramov, Hongyuan Wang, Dzhamal Abdurakhmanov, Young-Suk Lim, Maria Buti
Summary: Patients with CHB who switch from TDF to TAF show changes in lipid profiles but no significant impact on cardiovascular risk.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Biochemistry & Molecular Biology
Si-Cho Kim, Da-Won Kim, Eun Ju Cho, Jin-Young Lee, Jiwon Kim, Chaesun Kwon, Jeongsil Kim-Ha, Suk Kyun Hong, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Won Kim, Woojin Kim, Hyunsoo Kim, Yoon Jun Kim, Jung-Hwan Yoon, Su Jong Yu, Young-Joon Kim
Summary: To address the limitations of current HCC surveillance tests, this study identifies two HCC-specific methylation markers, RNF135 and LDHB, and develops a highly sensitive PCR method, MS-HRM, to detect them in cfDNA. The combined analysis of RNF135 and LDHB outperforms the AFP test in detecting HCC.
Article
Medicine, General & Internal
Heejoon Jang, Su Jong Yu, Hong Ghi Lee, Tae Min Kim, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Jung-Hwan Yoon, Yoon Jun Kim
Summary: The optimal duration of prophylactic antiviral therapy in patients with resolved HBV receiving rituximab is unclear. This study found that there is no significant difference in HBV reactivation between the 6-month and 12-month prophylactic TDF groups after completion of rituximab-based chemotherapy.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Ji Min Han, Youngil Koh, Sung Hwan Kim, Sung Yun Suh, Yoon Sook Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Hye Sun Gwak
Summary: This retrospective study evaluated the records of liver cirrhosis patients receiving dalteparin for portal vein thrombosis treatment. No history of variceal bleeding and newly developed thrombus before treatment were predictive factors associated with increased treatment response. Delay in starting treatment (more than three months or six months) was associated with a higher risk of relapse. Individualized dosing regimen (based on body weight) was more effective than fixed dosing regimen, with no observed bleeding complications.
MEDICINA-LITHUANIA
(2023)