Article
Biochemistry & Molecular Biology
Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon, Fu-Shi Quan
Summary: This study revealed that HDACi suppresses the expression of GPX8, sensitizing HCC cells to ER stress and oxidative stress, leading to apoptosis.
Letter
Oncology
Timothy L. Chen, Bonnie Harrington, Jean Truxall, Ronni Wasmuth, Alexander Prouty, Shelby Sloan, Amy M. Lehman, Deepa Sampath, Eric Orlemans, Robert A. Baiocchi, Lapo Alinari, John C. Byrd, Jennifer A. Woyach, Erin Hertlein
Summary: The Hsp90 inhibitor SNX-5422 has shown effectiveness in treating ibrutinib-resistant CLL, particularly when used in combination with ibrutinib, providing a significant survival benefit.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Christian Marx, Marc U. Schaarschmidt, Joanna Kirkpatrick, Lisa Marx-Bluemel, Melisa Halilovic, Martin Westermann, Doerte Hoelzer, Felix B. Meyer, Yibo Geng, Katrin Buder, Hauke M. Schadwinkel, Kanstantsin Siniuk, Sabine Becker, Rene Thierbach, James F. Beck, Juergen Sonnemann, Zhao-Qi Wang
Summary: The study suggests that combination treatment with HSP90 inhibitor and ATR inhibitor may be an effective therapeutic approach for Ewing's sarcoma, regardless of the p53 status.
CELL AND BIOSCIENCE
(2021)
Article
Food Science & Technology
Yalin Liu, Yifan Zhao, Jiaojiao Wu, Ting Liu, Mengke Tang, Ye Yao, Peng Xue, Miao He, Yanyi Xu, Peng Zhang, Minghua Gu, Weidong Qu, Yubin Zhang
Summary: This study reveals the previously unrecognized toxicity of lithium on hematopoietic stem cells, leading to an increase in lymphoid cells and a decrease in myeloid cells. It also highlights the impact of lithium on endoplasmic reticulum stress and Hsp90 signaling.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Miriam Longo, Marica Meroni, Erika Paolini, Veronica Erconi, Fabrizia Carli, Francesco Fortunato, Dario Ronchi, Roberto Piciotti, Silvia Sabatini, Chiara Macchi, Anna Alisi, Luca Miele, Giorgio Soardo, Giacomo Pietro Comi, Luca Valenti, Massimiliano Ruscica, Anna L. Fracanzani, Amalia Gastaldelli, Paola Dongiovanni
Summary: The study found that the co-presence of 3 at-risk variants, PNPLA3, TM6SF2, and MBOAT7, has a significant impact on the course of NAFLD in both patients and experimental models. It affects liver disease severity, LD accumulation, mitochondrial functionality, and metabolic reprogramming, leading to an increased risk of HCC.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Dong Zhao, Yi-Ming Xu, Lu-Qi Cao, Feng Yu, Huan Zhou, Wei Qin, Hui-Jin Li, Chun-Xia He, Lu Xing, Xin Zhou, Peng-Quan Li, Xin Jin, Yuan He, Jian-Hua He, Hui-Ling Cao
Summary: The study successfully determined the complex crystal structure of Hsp90(N)-SNX-2112, showing that SNX-2112 could effectively disable the molecular chaperone activity of Hsp90 in the ATP-binding pocket, exhibiting favorable inhibiting activity on non-small cell lung cancer cells. Novel SNX-2112 derivatives were designed based on the complex crystal structure and molecular interaction analysis, providing guidance for the development of new anti-NSCLC drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nidhi Sharma, Subhrajit Biswas, Noura Al-Dayan, Alaa Saud Alhegaili, Maryam Sarwat
Summary: Reactive oxygen species (ROS) are harmful to cells, leading to oxidative stress and endoplasmic reticulum stress, which are key biological factors in the progression of hepatocellular carcinoma (HCC). The use of antioxidants from herbal sources can significantly reduce oxidative stress, and kaempferol may serve as a potential candidate in preventing HCC.
Review
Biochemistry & Molecular Biology
Dong-Oh Moon
Summary: This review provides a comprehensive analysis of the multifaceted role of calcium in apoptosis regulation, focusing on its associated signaling pathways and molecular mechanisms. It explores the impact of calcium on apoptosis through its effects on various cellular compartments and highlights its connection to ER stress. Additionally, it discusses the interplay between calcium and proteins such as calpains, calmodulin, and Bcl-2 family members, and its role in regulating caspase activation and pro-apoptotic factor release. Understanding the complex relationship between calcium and apoptosis is crucial for identifying potential treatment options for diseases associated with imbalanced cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cheng-Yi Chang, Chih-Cheng Wu, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Wen-Yi Wang, Chun-Jung Chen
Summary: Elevation of intracellular cAMP levels through inhibition of phosphodiesterase using dipyridamole has shown to inhibit glioma cell proliferation, migration, and invasion. Dipyridamole induces apoptosis through Noxa-guided endoplasmic reticulum (ER) stress and impairs autophagic flux. YAP1 plays a role in the communication between ER stress and autophagy, promoting autophagy and protecting glioma cells from dipyridamole-induced apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhaolin Gao, Min Li, Fei Yao, Xiaobo Xia, Tianqi Duan, Jingzhuo Meng, Yanxia Huang, Ye He, Adonira Saro, Jufang Huang
Summary: The study investigated the effects and underlying mechanisms of valdecoxib on retinal ischemia-reperfusion injury and oxygen-glucose deprivation/recovery injury. The results showed that valdecoxib protected R28 cells by reducing cell apoptosis and exerted a protective effect on retinas by inhibiting retinal ganglion cell apoptosis. In addition, valdecoxib reversed the expression of certain proteins induced by glaucomatous model and the reversal was mediated by the PERK-ATF4-CHOP pathway. These findings suggest that valdecoxib protects against glaucomatous injury by inhibiting ER stress-induced apoptosis via the PERK-ATF4-CHOP pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kongdong Li, Chuanzhi Guo, Jiacheng Ruan, Bo Ning, Chris Kong-Chu Wong, Haifeng Shi, Jie Gu
Summary: Cadmium (Cd2+) exposure-induced cytotoxicity and renal injury can be protected against by activating the calcium-sensing receptor (CaSR) to restore the intracellular Ca2+ homeostasis through the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) channel. SERCA2 degradation caused by Cd2+ can be inhibited by the proteasome inhibitor MG132, indicating the involvement of the proteasomal protein degradation pathway in maintaining SERCA2 stability. Targeting SERCA2 and the associated proteasome may provide a new therapeutic approach for preventing Cd2+-induced cytotoxicity and renal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Summary: In this study, it was found that cadmium exposure induced cell death in HepG2 cells via a ROS-mediated PERK-CHOP-related apoptotic signaling pathway, providing a novel insight into the mechanisms of cadmium-induced hepatotoxicity. Inhibitors targeting oxidative stress and ER stress might be potential strategies for preventing or treating this disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Yufeng Wang, David L. Drum, Ruochuan Sun, Yida Zhang, Feng Chen, Fengfei Sun, Emre Dal, Ling Yu, Jingyu Jia, Shahrzad Arya, Lin Jia, Song Fan, Steven J. Isakoff, Allison M. Kehlmann, Gianpietro Dotti, Fubao Liu, Hui Zheng, Cristina R. Ferrone, Alphonse G. Taghian, Albert B. DeLeo, Marco Ventin, Giulia Cattaneo, Yongxiang Li, Youssef Jounaidi, Peigen Huang, Cristina Maccalli, Hanyu Zhang, Cheng Wang, Jibing Yang, Genevieve M. Boland, Ruslan I. Sadreyev, LaiPing Wong, Soldano Ferrone, Xinhui Wang
Summary: This study demonstrates a non-genetic approach to improve the efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors by reprogramming CAR T cells with stressed target cancer cells, resulting in the acquisition of memory-like characteristics and prolonged anti-tumor response in preclinical models.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Divya Saro Varghese, Deepu Oommen, Anne John, Bassam R. Ali
Summary: This study investigates the molecular mechanisms underlying the progression of oxLDL and ER stress-induced cytotoxicity in HepG2 cells. The results show that oxLDL induces ER stress response and leads to cytotoxicity and inflammatory responses. The study also finds that overexpression of BiP rescues hepatic cells and restores cellular homeostasis.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Cell Biology
Rita Dreier, Thomas Ising, Markus Ramroth, Yvonne Rellmann
Summary: Gender differences in osteoarthritis (OA) may be attributed to the differential response of males and females to endoplasmic reticulum (ER) stress in articular chondrocytes. This study demonstrates that the female sex hormone estradiol can reduce ER stress and ER stress-induced apoptosis in articular chondrocytes, thus minimizing critical events favoring osteoarthritic cartilage degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tu-Xiong Huang, Xiang-Yu Tan, Hui-Si Huang, Yu-Ting Li, Bei-Lei Liu, Kai-Sheng Liu, Xinchun Chen, Zhe Chen, Xin-Yuan Guan, Chang Zou, Li Fu
Summary: Solid tumours have poor response to ICI therapies due to the immunosuppressive TME, where CAFs play a key role in negatively regulating antitumor T-cell responses. Targeting WNT2 secreted by CAFs could enhance ICI efficacy and serve as a new approach for anticancer immunotherapy.
Article
Biochemistry & Molecular Biology
Ling Ou, Xinyou Wang, Shumin Cheng, Min Zhang, Ruiqin Cui, Chunxia Hu, Shiyi Liu, Qian Tang, Yuying Peng, Ruihuan Chai, Shouxia Xie, Shaoxiang Wang, Wei Huang, Xiao Wang
Summary: In this study, we found that verdinexor can inhibit the proliferation and migration of esophageal cancer cells, and exert its effects through the regulation of the XPO1/c-Myc/FOSL1 axis. This finding provides a new option for the development of anti-esophageal cancer drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huibin Song, Dongcheng Liu, Lingwei Wang, Kaisheng Liu, Chen Chen, Le Wang, Yi Ren, Bing Ju, Fuhua Zhong, Xingyu Jiang, Guangsuo Wang, Zhe-Sheng Chen, Chang Zou
Summary: This study demonstrates the crucial role of METTL7B in inducing resistance to EGFR-TKIs in lung adenocarcinoma. By regulating the mRNA modification of GPX4, HMOX1, and SOD1, METTL7B influences glutathione metabolism and drug sensitivity. These findings suggest that METTL7B inhibitors could serve as a potential treatment strategy for reversing EGFR-TKIs resistance in LUAD patients.
Article
Microbiology
Xiaowei Song, Yiliang Wang, Feng Li, Wenyan Cao, Qiongzhen Zeng, Shurong Qin, Zhaoyang Wang, Jiaoyan Jia, Ji Xiao, Xiao Hu, Kaisheng Liu, Yifei Wang, Zhe Ren
Summary: This study found that inhibitors of heat shock protein 90 (Hsp90) have antiviral activity against HSV-1 infection in neuronal cells. The results suggest that Hsp90 inhibitors promote viral adsorption but inhibit subsequent penetration, providing further insights into the molecular mechanism of Hsp90 in HSV-1 infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Shurong Qin, Xiao Hu, Shimin Lin, Ji Xiao, Zhaoyang Wang, Jiaoyan Jia, Xiaowei Song, Kaisheng Liu, Zhe Ren, Yifei Wang
Summary: This study demonstrates that Hsp90 inhibitors can directly target the HSV-1 UL42-Hsp90 complex and reduce virus titers of ACV-resistant HSV-1 strains. This provides a promising target for anti-HSV-1 therapies.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Cell Biology
Feng Li, Yifei Wang, Kai Zheng
Summary: This study reveals that gut microbial metabolites can regulate microglia-mediated neuroinflammation and mitigate the progression of herpes simplex encephalitis (HSE) by activating mitophagy. HSV-1 infection causes gut microbiota dysbiosis and hyperactivated microglia, while specific microbial metabolites can suppress HSE progression.
Article
Immunology
Tianhao Shan, Yanling Huang, Zibo Zhao, Feng Li, Yifei Wang, Cuifang Ye, Kai Zheng, Zhe Ren
Summary: This study shows that a ketogenic diet (KD), a low-carbohydrate high-fat diet, can restrict the neurotropic infection of HSV-1 and the progression of herpes simplex encephalitis (HSE) in mice. Depletion of gut microbes by antibiotics attenuated the protective function of KD on HSV-1-related neuroinflammation and HSE development.
MICROBES AND INFECTION
(2023)
Review
Virology
Ran Yan, Jiahao He, Ge Liu, Jianfeng Zhong, Jiapeng Xu, Kai Zheng, Zhe Ren, Zhendan He, Qinchang Zhu
Summary: Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. Currently, there is a lack of antiviral drugs in clinical practice for HFMD. Drug repositioning, specifically the repositioning of well-characterized therapeutics, is a potential strategy to identify new treatments for HFMD. Various types of drugs, including antibacterial, cardiovascular, and anticancer agents, have been studied for their therapeutic potential in treating HFMD.
Review
Biochemistry & Molecular Biology
Kai Zheng, Zhe Ren, Yifei Wang
Summary: Accumulating evidence has confirmed the interaction between viral infection and host alternative splicing. Serine-arginine (SR) proteins and serine-arginine protein kinases (SRPKs) play critical roles in spliceosome maturation, alternative splicing, and RNA metabolism. Viral proteins, as well as other cytoplasmic proteins, have been identified as substrates of SRPKs, highlighting the importance of SRPKs in virus-host interactions. This review discusses the regulation and biological function of SRPKs, their involvement in viral infection processes, the structure-function relationships of SRPK inhibitors, and the potential of targeting viral proteins and cellular substrates of SRPKs for antiviral therapy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Chemistry, Physical
Fanhui Kong, Qi Lei, Yi Ma, Peiying He, Guansheng Zheng, Yue Xu, Junda Huang, C. Jeffrey Brinker, Kaisheng Liu, Wei Zhu
Summary: By constructing a drug-loaded membrane fusion liposome, this study demonstrates a two-pronged strategy to trigger ferroptosis in cancer cells by delivering fatty acid hydroperoxide and blocking antioxidant systems.
CHEMISTRY OF MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Min Chen, Yanke Lin, Yongkang Dang, Yifei Xiao, Fugui Zhang, Guanghui Sun, Xuejun Jiang, Li Zhang, Jianhao Du, Shuyi Duan, Xiaojian Zhang, Zifei Qin, Jing Yang, Kaisheng Liu, Baojian Wu
Summary: This study reveals that the intestinal clock plays a crucial role in regulating liver rhythmicity and metabolism. The loss of the intestinal clock leads to a large-scale reprogramming of the liver transcriptome and alters hepatic metabolism. The intestinal clock controls the rhythmicity of the hepatic transcription factor SREBP-1c, which further affects hepatic lipogenesis and gluconeogenesis. These findings suggest that targeting intestinal rhythms may be a new approach for improving metabolic health.
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Houxiang Jiang, Shaoxiang Wang, Ying Liu, Chaopan Zheng, Lipeng Chen, Kai Zheng, Zhenyu Xu, Yong Dai, Hongtao Jin, Zhiqiang Cheng, Chang Zou, Li Fu, Kaisheng Liu, Xiaoshi Ma
Summary: This study identified EFNA1 as a key player in the progression of ESCC. The downregulation of EFNA1 inhibited cell proliferation and migration, activated cell cycle and autophagy. Additionally, a potential small molecule drug targeting EFNA1, salvianolic acid A (SAA), was found to suppress ESCC progression and enhance sensitivity to radiotherapy.
Article
Plant Sciences
Yuan Wang, Feng Li, Zexu Wang, Xiaowei Song, Zhe Ren, Xiao Wang, Yifei Wang, Kai Zheng
Summary: The study found that luteolin inhibits HSV-1 infection by activating the cGAS-STING pathway, promoting antiviral interferon production. In addition, luteolin can also alleviate HSV-1 infection-induced weight loss, neurodegeneration, and neuroinflammation.
Article
Medicine, Research & Experimental
Lianxia Guo, Haobin Cen, Jiaxian Weng, Yiting He, Xiaocao Guo, Di He, Kaisheng Liu, Shuyi Duan, Jing Yang, Xiaojian Zhang, Zifei Qin, Yong Wan, Zhiyong Chen, Baojian Wu
Summary: This study investigates the role of circadian clock in the development of pituitary adenomas. Altered expression of pituitary clock genes, especially PER2, is found in patients with pituitary adenomas. Jetlagged mice with PER2 upregulation show accelerated tumor growth, while loss of Per2 protects mice against estrogen-induced pituitary adenoma. Mechanistically, PER2 regulates the transcription of cell cycle genes to promote pituitary tumorigenesis. These findings advance our understanding of the relationship between circadian clock and pituitary adenomas, highlighting the relevance of clock-based approaches in disease management.
Article
Chemistry, Multidisciplinary
Zeyu Li, Liecong Xue, Junxian Yang, Stefan Wuttke, Peiying He, Chuanyi Lei, Haowei Yang, Liang Zhou, Jiangfan Cao, Anna Sinelshchikova, Guansheng Zheng, Jimin Guo, Jiangguo Lin, Qi Lei, C. Jeffrey Brinker, Kaisheng Liu, Wei Zhu
Summary: The researchers have developed armored red blood cell (RBC) biohybrids, which integrate urate oxidase and catalase enzymes within ZIF-8 framework-based nanoparticles, for fast-acting and long-lasting therapy for hyperuricemia. The biohybrids can effectively normalize the UA level of acute hyperuricemia model mice within 2 hours, and possess a longer elimination half-life compared to regular treatment options.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)