The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

Acute nutrient regulation of the mitochondrial glutathione redox state in pancreatic β-cells

(2014) Hilton K. Takahashi et al.   BIOCHEMICAL JOURNAL

The fat cell senescence hypothesis

(2014) Philip Newsholme et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Endoplasmic Reticulum Stress, Diabetes Mellitus, and Tissue Injury

(2014) Liu Huang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Glycoprotein 130 Receptor Signaling Mediates  -Cell Dysfunction in a Rodent Model of Type 2 Diabetes

(2014) S. Z. Chow et al.   DIABETES

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

(2014) Dominika Nackiewicz et al.   DIABETOLOGIA

Inhibition of NADPH oxidase-1 preserves beta cell function

(2014) Jessica R. Weaver et al.   DIABETOLOGIA

SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response

(2014) Diana J. Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression

(2014) Fábio Cangeri Di Naso et al.   Obesity

Heat stress: A risk factor for skin carcinogenesis

(2013) Leslie Calapre et al.   CANCER LETTERS

Hsp70 regulation on Nox4/p22phox and cytoskeletal integrity as an effect of losartan in vascular smooth muscle cells

(2013) Andrea Fernanda Gil Lorenzo et al.   CELL STRESS & CHAPERONES

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistancein vivoand cause pancreatic β-cell dysfunction and deathin vitro

(2013) Mauricio Krause et al.   CLINICAL SCIENCE

Heat Shock Prevents Insulin Resistance-Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling

(2013) P. A. Karpe et al.   DIABETES

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice

(2013) T. Teodoro-Morrison et al.   DIABETOLOGIA

Association Between Promoter Polymorphisms of the GRP78 Gene and Risk of Type 2 Diabetes in a Chinese Han Population

(2013) Shengyuan Liu et al.   DNA AND CELL BIOLOGY

Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

(2013) Ping Cao et al.   FEBS LETTERS

Heat shock transcription factor 1 attenuates TNFα-induced cardiomyocyte death through suppression of NFκB pathway

(2013) Lianpin Wu et al.   GENE

Localization and Expression of Hsp27 and αB-Crystallin in Rat Primary Myocardial Cells during Heat Stress In Vitro

(2013) Shu Tang et al.   PLoS One

Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes

(2013) Karen Pillay et al.   Biomed Research International

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?

(2012) Josianne Rodrigues-Krause et al.   CELL STRESS & CHAPERONES

A sympathetic view of human obesity

(2012) Elisabeth A. Lambert et al.   CLINICAL AUTONOMIC RESEARCH

NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion

(2012) N. Li et al.   DIABETES

Transcriptional regulation of small HSP—HSF1 and beyond

(2012) Aurélie de Thonel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

(2012) P Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets

(2012) Mauricio da Silva Krause et al.   JOURNAL OF ENDOCRINOLOGY

SIRT1 Protects against  -Synuclein Aggregation by Activating Molecular Chaperones

(2012) G. Donmez et al.   JOURNAL OF NEUROSCIENCE

Regulation of Cyclooxygenase-2 Expression by Heat: A Novel Aspect of Heat Shock Factor 1 Function in Human Cells

(2012) Antonio Rossi et al.   PLoS One

Oxidative Stress, Nox Isoforms and Complications of Diabetes—Potential Targets for Novel Therapies

(2012) Mona Sedeek et al.   Journal of Cardiovascular Translational Research

HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?

(2011) Thiago Gomes Heck et al.   CELL BIOCHEMISTRY AND FUNCTION

l-Arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge

(2011) Mauricio S Krause et al.   JOURNAL OF ENDOCRINOLOGY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Alterations of NADPH Oxidase Activity in Rat Pancreatic Islets Induced by a High-Fat Diet

(2011) Maíra Mello Rezende Valle et al.   PANCREAS

Glucose and Fatty Acids Synergize to Promote B-Cell Apoptosis through Activation of Glycogen Synthase Kinase 3β Independent of JNK Activation

(2011) Katsuya Tanabe et al.   PLoS One

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets

(2011) Maria Fernanda Graciano et al.   Islets

The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes

(2010) Vita Chien et al.   BIOCHEMICAL JOURNAL

Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: A form of communication during injury, infection, and cell damage

(2010) Antonio De Maio   CELL STRESS & CHAPERONES

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

(2010) J. A. Ehses et al.   DIABETOLOGIA

Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse

(2010) L.-H. Kuo et al.   DIABETOLOGIA

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

(2010) Y. Liu et al.   DIABETOLOGIA

Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells

(2010) Huiping Yuan et al.   FEBS Journal

Inhibition of the JNK/Bim pathway by Hsp70 prevents Bax activation in UV-induced apoptosis

(2010) Hui Li et al.   FEBS LETTERS

Intracellular generation of superoxide by the phagocyte NADPH oxidase: How, where, and what for?

(2010) Johan Bylund et al.   FREE RADICAL BIOLOGY AND MEDICINE

β-Arrestin 2 regulates toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β

(2010) Hui Li et al.   IMMUNOLOGY

Exendin-4 Protects Oxidative Stress-Induced β-Cell Apoptosis through Reduced JNK and GSK3β Activity

(2010) Ju-Young Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities

(2010) Jiankun Zhu et al.   MEDIATORS OF INFLAMMATION

Extracellular heat shock proteins (eHSP70) in exercise: Possible targets outside the immune system and their role for neurodegenerative disorders treatment

(2010) Mauricio Krause et al.   MEDICAL HYPOTHESES

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

TLR4 and Insulin Resistance

(2010) Jane J. Kim et al.   Gastroenterology Research and Practice

Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice

(2009) Dariush Mokhtari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK-mediated GSK3β inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress

(2009) Song Hwa Choi et al.   BIOCHEMICAL PHARMACOLOGY

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Innate immunity and heat shock response in islet transplantation

(2009) Y. Lai et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

(2009) Philip Newsholme et al.   CLINICAL SCIENCE

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

(2009) M. D. McKenzie et al.   DIABETES

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

(2009) P. Newsholme et al.   DIABETOLOGIA

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Tlr2 is critical for diet-induced metabolic syndrome in a murine model

(2009) Ryan W. Himes et al.   FASEB JOURNAL

Toll-Like Receptor-4 Inhibits Enterocyte Proliferation via Impaired β-Catenin Signaling in Necrotizing Enterocolitis

(2009) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Heat shock protein 72 protects insulin-secreting beta cells from lipopolysaccharide-induced endoplasmic reticulum stress

(2009) Satoshi Hagiwara et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

WHO recognition of the global obesity epidemic

(2009) W P T James   INTERNATIONAL JOURNAL OF OBESITY

A Clear and Present Danger: Endogenous Ligands of Toll-like Receptors

(2009) Jacob A. Sloane et al.   NEUROMOLECULAR MEDICINE

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Heat shock proteins and exercise: a primer

(2008) Earl G. Noble et al.   Applied Physiology Nutrition and Metabolism

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

(2008) A. A. Gupte et al.   DIABETES

Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation

(2008) Z. Liu et al.   DIABETOLOGIA

Contribution of IL-6 to the Hsp72, Hsp25, and αβ-crystallin responses to inflammation and exercise training in mouse skeletal and cardiac muscle

(2008) Kimberly A. Huey et al.   JOURNAL OF APPLIED PHYSIOLOGY

Inducible Toll-like Receptor and NF-κB Regulatory Pathway Expression in Human Adipose Tissue

(2008) Olga I. Vitseva et al.   Obesity

Interleukin-6 regulates pancreatic  -cell mass expansion

(2008) H. Ellingsgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance

(2008) Katsuya Tanabe et al.   PLOS BIOLOGY