Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Gino Seravalle, Rita Facchetti, Cecilia Cappellini, Alessandra Annaloro, Elia Gel, Guido Grassi
Summary: This study aimed to determine whether a specific heart rate can accurately identify the level of adrenergic overdrive in obese individuals. The results showed that resting heart rate may not accurately reflect the functional status of the adrenergic cardiovascular drive in obese individuals. In contrast, healthy lean controls displayed significant differences in sympathetic nerve activity based on heart rate values.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Christian A. Reynolds, Zeljka Minic
Summary: Chronic pain is linked to the development of cardiovascular disease through activation of the sympathetic nervous system. This review provides evidence for the direct relationship between sympathetic nervous system dysfunction and chronic pain. Maladaptive changes in the neural network regulating sympathetic nervous system and pain perception contribute to sympathetic overactivation and cardiovascular disease in chronic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Yantao Xing, Yike Zhang, Zhijun Xiao, Chenxi Yang, Jiayi Li, Chang Cui, Jing Wang, Hongwu Chen, Jianqing Li, Chengyu Liu
Summary: This study proposed a method using TKE operator to preprocess SKNA signal, improved the detection accuracy for SKNA bursts with SKNAER feature, and showed significant differences in SNA evaluation compared to traditional methods.
Review
Biochemistry & Molecular Biology
Lu Qin, Jian Cui, Jianhua Li
Summary: This review discusses the impact of sympathetic nerve activity on blood pressure in patients with peripheral artery disease and the related neural mechanisms, and proposes intervention strategies to improve the deleterious effects of exercise-induced blood pressure changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Bartek Kulas, Stephen A. Klassen, M. Erin Moir, J. Kevin Shoemaker
Summary: This study examines the effects of baroreceptor unloading and volitional end-expiratory apnea on the firing patterns of sympathetic postganglionic neurons. The results suggest that these factors can modify the discharge rate, recruitment, and latency of sympathetic neurons.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Physiology
Shizuka Ikegame, Misa Yoshimoto, Kenju Miki
Summary: This study investigated the functional relationships between central amygdala neuronal activity (CeANA) and sympathetic nerve activity (SNA) in freely moving rats. The results showed that CeANA was related to RSNA, LSNA and HR in a behavioral state-dependent and regionally different manner. This suggests that the amygdala may play a role in generating regional differences in sympathetic nerve activity.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Neurosciences
Ying Zhu, Ai Yan, Bin Shu, Xuehan Chen, Yupei Chen, Guangyou Duan, He Huang
Summary: This study aimed to investigate the diurnal rhythm of basal pain sensitivity and its association with sympathetic nerve activity in healthy volunteers. Significant diurnal fluctuations were observed in experimental pain sensitivity and skin sympathetic nerve activity. However, there was no significant correlation between experimental pain sensitivity and sympathetic excitability at different times.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kosuke Otani, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, Hideyuki Yamawaki
Summary: This study investigated changes in cardiovascular dynamics, adipose tissue, and kidney pathology associated with obesity and T2D in ZFDM rats. The results showed that heart rate and plasma adrenaline concentration decrease with the progression of obesity and T2D in ZFDM rats. In addition, inflammation occurs in perirenal white adipose tissue, while degeneration and whitening occur in interscapular brown adipose tissue. Furthermore, renal function is impaired. ZFDM rats will be useful for studying metabolic changes associated with obesity and T2D progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yantao Xing, Yike Zhang, Chenxi Yang, Jianqing Li, Yuwen Li, Chang Cui, Jiayi Li, Hongyi Cheng, Yin Fang, Cheng Cai, Minglong Chen, Chengyu Liu
Summary: The proposed portable monitoring system based on skin sympathetic nerve activity (SKNA) allows simultaneous recording of SKNA and electrocardiogram (ECG). By modifying the analog front end (AFE) chip and using filtering and clipping techniques, the system achieves low noise levels and effectively rejects artifacts. Both laboratory and clinical experiments demonstrate the system's good performance and feasibility for autonomic nervous system assessment.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Physiology
Zhipeng Cai, Hongyi Cheng, Yantao Xing, Feifei Chen, Yike Zhang, Chang Cui
Summary: The proposed autonomic nervous activity analysis method based on VG and SKNA offers a new insight into ANS assessment in UST segments and ANS-Load quantification.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Kenju Miki, Shizuka Ikegame, Misa Yoshimoto
Summary: This review discusses how multiple baroreflex loops modulate sympathetic nerve activity in a region-specific and coordinated manner throughout the body, through evaluating the responses during freezing, REM sleep, and treadmill exercise.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Joseph C. Watso, Mu Huang, Gilbert Moralez, Matthew N. Cramer, Joseph M. Hendrix, Frank A. Cimino, Luke N. Belval, Carmen Hinojosa-Laborde, Craig G. Crandall
Summary: The study found that low dose ketamine administration can reduce pain perception and some cardiovascular responses, but does not affect muscle sympathetic nerve activity burst frequency. This suggests that low dose ketamine is effective in pain management.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Sport Sciences
Megan M. Wenner, Jody L. Greaney, Evan L. Matthews, Shane Mcginty, Jasdeep Kaur, Wanpen Vongpatanasin, Paul J. Fadel
Summary: Postmenopausal women display exaggerated blood pressure and muscle sympathetic nerve activity responses during exercise compared to young women. Estradiol administration attenuates these responses.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Peripheral Vascular Disease
Isao Usui
Summary: Hypertension and type 2 diabetes often occur together due to shared pathophysiological mechanisms. Both diseases are induced by factors such as obesity-induced hyperinsulinemia, activation of the sympathetic nervous system, chronic inflammation, and changes in adipokines. Vascular complications resulting from these diseases include endothelial dysfunction, peripheral vasodilation/constriction dysfunction, arteriosclerosis, and chronic kidney disease. Insulin resistance in the vasculature and increased fluid volume are major factors contributing to elevated blood pressure in obese and insulin-resistant patients, while peripheral vascular resistance plays a major role in hypertension in non-obese and/or insulin-deficient patients.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Nina Eikelis, John B. Dixon, Elisabeth A. Lambert, Geula Hanin, Yonat Tzur, David S. Greenberg, Hermona Soreq, Francine Z. Marques, Michael T. Fahey, Geoffrey A. Head, Markus P. Schlaich, Gavin W. Lambert
Summary: The study revealed an association between miR-132 and markers of cardiovascular and metabolic disease, suggesting that reduction of miR-132 may be a target for regulating liver lipid homeostasis and controlling obesity-related blood pressure.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Clinical Neurology
Zoe M. Jenkins, David J. Castle, Nina Eikelis, Andrea Phillipou, Gavin W. Lambert, Elisabeth A. Lambert
Summary: Abnormalities in autonomic function have been observed in individuals with anorexia nervosa. This study used various methodologies to assess autonomic nervous system function in women with both current and past diagnoses of anorexia, as well as in healthy controls. The results showed that women with anorexia had significantly decreased sympathetic activity, potentially due to reduced energy intake, and weight-restored participants also displayed some abnormalities in autonomic function. Future studies should investigate whether autonomic activity returns to normal in long-term weight-restored participants.
CLINICAL AUTONOMIC RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Melissa G. Y. Lee, Taryn L. Luitingh, Phillip S. Naimo, Elisabeth Lambert, Michael M. H. Cheung, Igor E. Konstantinov, Christian P. Brizard, Gavin Lambert, Yves d'Udekem
Summary: This study investigated the functional and mental health status of young adults with previous coarctation repair and the impact of late hypertension on their quality of life. The study found that adults with previous coarctation repair reported poorer physical health and tended towards higher anxiety trait compared to healthy controls.
HEART LUNG AND CIRCULATION
(2022)
Article
Peripheral Vascular Disease
Revathy Carnagarin, Janis M. Nolde, Rebecca Lee, Leslie Marisol Lugo-Gavidia, Natalie C. Ward, Gavin W. Lambert, Elisabeth A. Lambert, Murray D. Esler, Antony Walton, Marcio Galindo Kiuchi, Markus P. Schlaich
Summary: This study investigated the effect of renal denervation (RDN) on salt sensitivity in hypertensive patients and found that RDN increased salt sensitivity, which may represent a compensatory mechanism of the kidneys to maintain adequate salt handling. This finding has important implications for patient management after RDN.
JOURNAL OF HYPERTENSION
(2022)
Article
Rehabilitation
Clara C. Zwack, Rachael McDonald, Ainura Tursunalieva, Shradha Vasan, Gavin W. Lambert, Elisabeth A. Lambert
Summary: The study showed that adults with intellectual disabilities experience higher levels of perceived stress compared to those without disabilities, likely due to unique stressors they face. Stress is strongly associated with social isolation, obesity in females with mild intellectual disabilities, and arterial stiffness.
DISABILITY AND REHABILITATION
(2023)
Review
Cardiac & Cardiovascular Systems
Edgar M. Hidalgo, Leah Wright, Mats Isaksson, Gavin Lambert, Thomas H. Marwick
Summary: With advances in robotics and telecommunications, robot-assisted teleoperated ultrasound examination can help with medical diagnosis in remote areas, reducing health inequalities. Studies have shown that robots can safely perform ultrasound examinations by following the hand movements of sonographers and researchers. However, real-time transmission of video and ultrasound images requires high bandwidth, and improvements are needed in robot control and interface design.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Peripheral Vascular Disease
Revathy Carnagarin, Janis M. Nolde, Jun Yang, Francine Z. Marques, Dean S. Picone, Gavin W. Lambert, Thomas Beaney, Neil R. Poulter, Aletta E. Schutte, Christopher M. Reid, Derrin Brockman, Markus P. Schlaich
Summary: The awareness, treatment, and control rates of hypertension in Australia are substantially lower than global and high-income country rates, indicating the need for collaborative efforts to improve the situation.
JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Fakir M. Amirul Islam, Mohammad Ariful Islam, Mohammad Arzan Hosen, Elisabeth A. Lambert, Ralph Maddison, Gavin W. Lambert, Bruce R. Thompson
Summary: Engaging in high physical activity and having a positive attitude towards physical activity are associated with lower blood pressure levels in rural Bangladesh. Awareness programs should be implemented to promote the benefits of physical activity and increase participation in high physical activity.
Article
Psychology, Clinical
Daniel J. van den Hoek, Clint T. Miller, Steve F. Fraser, Steve E. Selig, Toni Rice, Mariee Grima, Carolina Ika Sari, Gavin W. Lambert, John B. Dixon
Summary: This study explored the effects of dietary weight loss intervention, with and without exercise, on health-related quality of life, depressive symptoms, and anxiety in premenopausal women. The results showed that the addition of exercise to energy restriction had a significant positive impact on health-related quality of life, depressive symptoms, and state and trait anxiety scores. Exercise can improve mental health and quality of life in women with severe obesity without further weight loss.
JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Gianni Sesa-ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Rebecca Lee, Vaughan G. Macefield, Tye Dawood, Yusuke Sata, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Marcio G. Kiuchi, Murray D. Esler, Markus P. Schlaich
Summary: Long-term follow-up studies on catheter-based renal denervation in patients with resistant hypertension show that the method can still effectively reduce blood pressure and decrease medication usage after nearly 9 years of follow-up, without any adverse effects on renal function.
Article
Cell Biology
Aeson Chang, Edoardo Botteri, Ryan D. Gillis, Lukas Lofling, Caroline P. Le, Alexandra I. Ziegler, Ni-Chun Chung, Matthew C. Rowe, Stewart A. Fabb, Brigham J. Hartley, Cameron J. Nowell, Sasagu Kurozumi, Sara Gandini, Elisabetta Munzone, Emilia Montagna, Nina Eikelis, Sarah E. Phillips, Chikako Honda, Kei Masuda, Ayaka Katayama, Tetsunari Oyama, Steve W. Cole, Gavin W. Lambert, Adam K. Walker, Erica K. Sloan
Summary: We found a relationship between beta-blocker use and anthracycline chemotherapy in protecting against TNBC progression, disease recurrence, and mortality. Beta-blockade improved the efficacy of anthracycline chemotherapy in TNBC mouse models by reducing metastatic development. Anthracycline chemotherapy increased sympathetic nerve fiber activity and norepinephrine concentration in mammary tumors, but this effect can be overcome by inhibiting beta 2-adrenergic signaling in the tumor microenvironment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Mansi Patil, Radhika Prashant Hedaoo, Rohan Pravinbhai Shah, Syed Mohammad Tauseef, Roy Rillera Marzo, Siew Mooi Ching, Gavin Lambert
Summary: The burden of hypertension has been increasing, and besides the risk of stroke and cardiovascular disease, it also affects the quality of life (QoL) of individuals. This study aimed to assess the QoL of hypertensive men undergoing treatment in India. The results showed that patients with uncontrolled hypertension had significantly poorer QoL compared to those with controlled blood pressure.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2023)
Meeting Abstract
Peripheral Vascular Disease
Markus Schlaich, Jonathon Sesa-Ashton, Rebecca Lee, Elisabeth Lambert, Gavin Lambert, Janis Nolde, Antony Walton, Murray Esler
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jason E. Bloom, Daniel Donner, Waled Shihata, Aascha Brown, Tsin Yee Tai, Gavin W. Lambert, Po-Yin Chu, William Chan, Dion Stub, Bing Wang, David M. Kaye
Article
Critical Care Medicine
Daniel G. Donner, Jason E. Bloom, Waled A. Shihata, Aascha A. Brown, Rosalind Cook, Tsin Yee Tai, Gavin W. Lambert, Po-Yin Chu, William Chan, Dion Stub, Bing H. Wang, David M. Kaye
Summary: This study evaluated the effects of adrenaline use during cardiac arrest resuscitation, and found that it did not improve survival rates. In fact, following successful return of spontaneous circulation, the use of adrenaline led to significantly higher mortality rates. Additionally, adrenaline was associated with increased myocardial injury, organ inflammation, and fibrosis. These findings highlight the need for further research on alternative pharmacologic adjuncts for cardiopulmonary resuscitation to improve survival and reduce organ injury.
RESUSCITATION PLUS
(2022)
