Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression

The fat cell senescence hypothesis

(2014) Philip Newsholme et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response

(2013) Rachel Raynes et al.   PLoS One

The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype

(2012) Geunwon Kim et al.   AGING CELL

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?

(2012) Josianne Rodrigues-Krause et al.   CELL STRESS & CHAPERONES

Hepatic nitrosative stress in experimental diabetes

(2012) Fábio Cangeri Di Naso et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up

(2012) Shira Zelber-Sagi et al.   JOURNAL OF HEPATOLOGY

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

(2012) Aloysious Aravinthan et al.   JOURNAL OF HEPATOLOGY

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice

(2011) Virginia Maina et al.   CLINICAL SCIENCE

Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice

(2011) X. Zhang et al.   DIABETES

Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High-Fat Diet

(2011) Brante P. Sampey et al.   Obesity

JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease

(2011) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling

(2009) Alicia H. Clementi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibiting the transcription factor HSF1 as an anticancer strategy

(2009) Luke Whitesell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

(2009) C.-Y. Wang et al.   Science Signaling

Atherosclerosis: A redox-sensitive lipid imbalance suppressible by cyclopentenone prostaglandins

(2008) Lucila Ludmila Paula Gutierrez et al.   BIOCHEMICAL PHARMACOLOGY

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA