The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements

Mechanical control of the sense of touch by β-spectrin

(2014) Michael Krieg et al.   NATURE CELL BIOLOGY

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+channels

(2014) Stephen G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feeling the hidden mechanical forces in lipid bilayer is an original sense

(2014) A. Anishkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR-based technologies: prokaryotic defense weapons repurposed

(2014) Rebecca M. Terns et al.   TRENDS IN GENETICS

Phospholipids that Contain Polyunsaturated Fatty Acids Enhance Neuronal Cell Mechanics and Touch Sensation

(2014) Valeria Vásquez et al.   Cell Reports

Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol

(2013) Marc Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechano-Gated Ion Channels in Sensory Systems

(2013) Patrick Delmas et al.   CELL

The puzzle of TRPV4 channelopathies

(2013) Bernd Nilius et al.   EMBO REPORTS

Multidimensional View of the Bacterial Cytoskeleton

(2013) K. Celler et al.   JOURNAL OF BACTERIOLOGY

The Purified Mechanosensitive Channel TREK-1 Is Directly Sensitive to Membrane Tension

(2013) Catherine Berrier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A force of nature: molecular mechanisms of mechanoperception in plants

(2013) Gabriele B. Monshausen et al.   JOURNAL OF EXPERIMENTAL BOTANY

The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels

(2013) Kyunghee X. Kim et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain

(2013) Jizhe Hao et al.   NEURON

Stiffened lipid platforms at molecular force foci

(2013) A. Anishkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

(2013) Carlene Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes

(2013) N. W. Bellono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel

(2013) S. G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosaminoglycan-Binding Hydrogels Enable Mechanical Control of Human Pluripotent Stem Cell Self-Renewal

(2012) Samira Musah et al.   ACS Nano

In vivoElectrophysiological Characterization of TASK-1 Deficient Mice

(2012) Stella Petric et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Kinocilia Mediate Mechanosensitivity in Developing Zebrafish Hair Cells

(2012) Katie S. Kindt et al.   DEVELOPMENTAL CELL

Large Membrane Domains in Hair Bundles Specify Spatially Constricted Radixin Activation

(2012) H. Zhao et al.   JOURNAL OF NEUROSCIENCE

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels

(2012) D. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Putting the Squeeze on Phototransduction

(2012) E. R. Liman   SCIENCE

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

Photomechanical Responses in Drosophila Photoreceptors

(2012) R. C. Hardie et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Force-dependent cell signaling in stem cell differentiation

(2012) Evelyn KF Yim et al.   Stem Cell Research & Therapy

Melanopsin and Mechanisms of Non-visual Ocular Photoreception

(2011) Timothy Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

(2011) Kumar N. Alagramam et al.   PLoS One

Increased Basal Activity Is a Key Determinant in the Severity of Human Skeletal Dysplasia Caused by TRPV4 Mutations

(2011) Stephen Loukin et al.   PLoS One

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

(2011) D. E. Clapham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional ion channels in stem cells

(2011) Gui-Rong Li   World Journal of Stem Cells

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Biophysics and Structure of the Patch and the Gigaseal

(2009) Thomas M. Suchyna et al.   BIOPHYSICAL JOURNAL

Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids

(2009) Stephen H. Loukin et al.   FEBS LETTERS

Sensing of Blood Pressure Increase by Transient Receptor Potential Vanilloid 1 Receptors on Baroreceptors

(2009) H. Sun et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Lipid-Protein Interactions along the Slit Diaphragm of Podocytes

(2009) B. Schermer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

(2009) J. A. Lundbaek et al.   Journal of the Royal Society Interface

The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation

(2009) Yongjun Lu et al.   NEURON

TRPV4-Mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts

(2008) Ritsuko Masuyama et al.   Cell Metabolism

Actin stress fibers transmit and focus force to activate mechanosensitive channels

(2008) Kimihide Hayakawa et al.   JOURNAL OF CELL SCIENCE

Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss

(2008) Fumitaka Mizoguchi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Substrate rigidity regulates Ca2+oscillation via RhoA pathway in stem cells

(2008) Tae-Jin Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Contribution of TRPV channels to osmosensory transduction, thirst, and vasopressin release

(2008) R. Sharif-Naeini et al.   KIDNEY INTERNATIONAL

Central mechanisms of osmosensation and systemic osmoregulation

(2008) Charles W. Bourque   NATURE REVIEWS NEUROSCIENCE

TRP channels and mechanosensory transduction: insights into the arterial myogenic response

(2008) Reza Sharif-Naeini et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Membrane mechanics as a probe of ion-channel gating mechanisms

(2008) Daniel Reeves et al.   PHYSICAL REVIEW E

Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane

(2008) D. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA