Structural characterization of the heme-based oxygen sensor,AfGcHK, its interactions with the cognate response regulator, and their combined mechanism of action in a bacterial two-component signaling system

Membrane-Anchored Cytochrome P450 1A2–Cytochrome b5 Complex Features an X-Shaped Contact between Antiparallel Transmembrane Helices

(2016) Petr Jeřábek et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Kinetic Analysis of a Globin-Coupled Histidine Kinase, AfGcHK: Effects of the Heme Iron Complex, Response Regulator, and Metal Cations on Autophosphorylation Activity

(2015) Veronika Fojtikova et al.   BIOCHEMISTRY

Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis

(2015) Daniel J. Frank et al.   BIOCHEMISTRY

Gaseous O2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors

(2015) Toru Shimizu et al.   CHEMICAL REVIEWS

The ins and outs of selective kinase inhibitor development

(2015) Susanne Müller et al.   Nature Chemical Biology

Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy

(2015) Wooseong Kim et al.   PLoS One

Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen

(2015) Jonathan W. Willett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic sensing by the inner membrane histidine kinase EnvZ

(2015) Yong Hwee Foo et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Signal Transduction in Histidine Kinases: Insights from New Structures

(2015) Manasi P. Bhate et al.   STRUCTURE

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase dependent activity inFrancisella novicida

(2015) Scott N Dean et al.   Virulence

Structural analysis of an oxygen-regulated diguanylate cyclase

(2015) Miroslaw Tarnawski et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

(2014) Ulrike Leurs et al.   ANALYTICAL CHEMISTRY

Flexible Docking-Based Molecular Dynamics/Steered Molecular Dynamics Calculations of Protein–Protein Contacts in a Complex of Cytochrome P450 1A2 with Cytochrome b5

(2014) Petr Jeřábek et al.   BIOCHEMISTRY

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

Pressure effects reveal that changes in the redox states of the heme iron complexes in the sensor domains of two heme-based oxygen sensor proteins,EcDOS and YddV, have profound effects on their flexibility

(2014) Pavel Anzenbacher et al.   FEBS Journal

The Assembly and Intermolecular Properties of the Hsp70-Tomm34-Hsp90 Molecular Chaperone Complex

(2014) Filip Trcka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase

(2014) C. M. Casadei et al.   SCIENCE

Cell Fate Regulation Governed by a Repurposed Bacterial Histidine Kinase

(2014) W. Seth Childers et al.   PLOS BIOLOGY

Heme Sensor Proteins

(2013) Hazel M. Girvan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme-based Globin-coupled Oxygen Sensors: Linking Oxygen Binding to Functional Regulation of Diguanylate Cyclase, Histidine Kinase, and Methyl-accepting Chemotaxis

(2013) Markéta Martínková et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helix Bundle Loops Determine Whether Histidine Kinases Autophosphorylate in cis or in trans

(2013) Orr Ashenberg et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of a Rationally Rewired Protein-Protein Interface Critical to Bacterial Signaling

(2013) Anna I. Podgornaia et al.   STRUCTURE

Identification and Functional and Spectral Characterization of a Globin-coupled Histidine Kinase fromAnaeromyxobactersp. Fw109-5

(2011) Kenichi Kitanishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of cysteine thiolate to the Fe(III) heme complex is critical for the function of heme sensor proteins

(2011) Toru Shimizu   JOURNAL OF INORGANIC BIOCHEMISTRY

Diversity of structure and function of response regulator output domains

(2010) Michael Y Galperin   CURRENT OPINION IN MICROBIOLOGY

The HADDOCK web server for data-driven biomolecular docking

(2010) Sjoerd J de Vries et al.   Nature Protocols

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Transient Protein-Protein Interactions: Structural, Functional, and Network Properties

(2010) James R. Perkins et al.   STRUCTURE

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction

(2009) Patricia Casino et al.   CELL

Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics

(2009) Urs Jenal et al.   CURRENT OPINION IN MICROBIOLOGY

Recombinant immobilized rhizopuspepsin as a new tool for protein digestion in hydrogen/deuterium exchange mass spectrometry

(2009) Martial Rey et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Protein-Protein Docking and Analysis Reveal That Two Homologous Bacterial Adenylyl Cyclase Toxins Interact with Calmodulin Differently

(2008) Qing Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of the Heme Binding Site of Heme-regulated Eukaryotic Initiation Factor 2α Kinase and the Role of the Regulatory Motif in Heme Sensing by Spectroscopic and Catalytic Studies of Mutant Proteins

(2008) Jotaro Igarashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HisE11 and HisF8 Provide Bis-histidyl Heme Hexa-coordination in the Globin Domain of Geobacter sulfurreducens Globin-coupled Sensor

(2008) Alessandra Pesce et al.   JOURNAL OF MOLECULAR BIOLOGY