Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase dependent activity inFrancisella novicida

Francisella philomiragia Biofilm Formation and Interaction With the Aquatic Protist Acanthamoeba castellanii

(2016) Anne B. Verhoeven et al.   BIOLOGICAL BULLETIN

The Lipopeptide Antibiotic Paenibacterin Binds to the Bacterial Outer Membrane and Exerts Bactericidal Activity through Cytoplasmic Membrane Damage

(2014) E. Huang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacterial Serine/Threonine Protein Kinases in Host-Pathogen Interactions

(2014) Marc J. Canova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protein tyrosine kinases EpsB and PtkA differentially affect biofilm formation in Bacillus subtilis

(2014) J. Gerwig et al.   MICROBIOLOGY-SGM

Collateral damage

(2014) Robert E W Hancock   NATURE BIOTECHNOLOGY

QseC Inhibitors as an Antivirulence Approach for Gram-Negative Pathogens

(2014) Meredith M. Curtis et al.   mBio

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

A new dye uptake assay to test the activity of antibiotics against intracellular Francisella tularensis

(2014) Vivien Sutera et al.   Frontiers in Cellular and Infection Microbiology

New anti-infective strategies for treatment of tularemia

(2014) Max Maurin   Frontiers in Cellular and Infection Microbiology

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

(2013) Kovi Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs

(2013) Ren Sun et al.   BMC MICROBIOLOGY

Evolution toward high-level fluoroquinolone resistance in Francisella species

(2013) Vivien Sutera et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

(2013) Peter B. Madrid et al.   PLoS One

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

(2013) L. M. Johansen et al.   Science Translational Medicine

Standardized broth microdilution antimicrobial susceptibility testing of Francisella tularensis subsp. holarctica strains from Europe and rare Francisella species

(2012) E. Georgi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

(2012) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

EvolView, an online tool for visualizing, annotating and managing phylogenetic trees

(2012) Huangkai Zhang et al.   NUCLEIC ACIDS RESEARCH

Lipophilic Prodrugs of FR900098 Are Antimicrobial against Francisella novicida In Vivo and In Vitro and Show GlpT Independent Efficacy

(2012) Elizabeth S. McKenney et al.   PLoS One

Resistance of Francisella Novicida to Fosmidomycin Associated with Mutations in the Glycerol-3-Phosphate Transporte

(2012) Ryan S. Mackie et al.   Frontiers in Microbiology

Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus

(2011) Scott N Dean et al.   BMC MICROBIOLOGY

Steroid hormones as bactericidal agents to Helicobacter pylori

(2011) Kouichi Hosoda et al.   FEMS MICROBIOLOGY LETTERS

ChemMine tools: an online service for analyzing and clustering small molecules

(2011) T. W. H. Backman et al.   NUCLEIC ACIDS RESEARCH

Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37

(2011) Scott N. Dean et al.   Frontiers in Microbiology

Antimicrobial and antibiofilm activity of cathelicidins and short, synthetic peptides against Francisella

(2010) Lilian S. Amer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Azithromycin effectiveness against intracellular infections of Francisella

(2010) Saira Ahmad et al.   BMC MICROBIOLOGY

Regulation of Virulence Gene Transcripts by the Francisella novicida Orphan Response Regulator PmrA: Role of Phosphorylation and Evidence of MglA/SspA Interaction

(2010) B. L. Bell et al.   INFECTION AND IMMUNITY

Phenotypic and genetic characterization of macrolide resistance in Francisella tularensis subsp. holarctica biovar I

(2010) Brieuc Gestin et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Proteomic Characterization and Functional Analysis of Outer Membrane Vesicles of Francisella novicida Suggests Possible Role in Virulence and Use as a Vaccine

(2010) Tony Pierson et al.   JOURNAL OF PROTEOME RESEARCH

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth

(2009) K. Iljin et al.   CLINICAL CANCER RESEARCH

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Francisella novicida Forms In Vitro Biofilms Mediated by an Orphan Response Regulator

(2009) Meghan W. Durham-Colleran et al.   MICROBIAL ECOLOGY

Repurposing with a Difference

(2009) M. S. Boguski et al.   SCIENCE

Antimicrobial activity of human beta-defensins and induction by Francisella

(2008) SuHua Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Generation and Characterization of an Attenuated Mutant in a Response Regulator Gene of Francisella tularensis Live Vaccine Strain (LVS)

(2008) Wendy L. Sammons-Jackson et al.   DNA AND CELL BIOLOGY

Rapid comparative genomic analysis for clinical microbiology: The Francisella tularensis paradigm

(2008) B. La Scola et al.   GENOME RESEARCH

Targeting QseC Signaling and Virulence for Antibiotic Development

(2008) D. A. Rasko et al.   SCIENCE