Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins

MUC1-C drives MYC in multiple myeloma

(2016) Ashujit Tagde et al.   BLOOD

Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease

(2016) H van Andel et al.   ONCOGENE

The osteoblastic niche in the context of multiple myeloma

(2014) Denise Toscani et al.   Annals of the New York Academy of Sciences

Osteoblastic niche supports the growth of quiescent multiple myeloma cells

(2014) Z. Chen et al.   BLOOD

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy

(2014) Jens G. Lohr et al.   CANCER CELL

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

GP130 activation induces myeloma and collaborates with MYC

(2014) Tobias Dechow et al.   JOURNAL OF CLINICAL INVESTIGATION

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy

(2013) G. Mulligan et al.   BLOOD

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding the Pathophysiology and the Genetics of Multiple Myeloma to Identify New Therapeutic Targets

(2013) Panisinee Lawasut et al.   SEMINARS IN ONCOLOGY

Stat3 Upregulates Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4 Expression in Osteosarcoma Cells

(2013) Jia Liu et al.   Biomed Research International

Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling

(2012) D. Horst et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

A pipeline for the generation of shRNA transgenic mice

(2012) Lukas E Dow et al.   Nature Protocols

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional Silencing of the Wnt-Antagonist DKK1 by Promoter Methylation Is Associated with Enhanced Wnt Signaling in Advanced Multiple Myeloma

(2012) Kinga A. Kocemba et al.   PLoS One

Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling

(2012) K. Takada et al.   Science Translational Medicine

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group

(2010) Torsten Haferlach et al.   JOURNAL OF CLINICAL ONCOLOGY

Aurora kinase A is a target of Wnt/ -catenin involved in multiple myeloma disease progression

(2009) J. Dutta-Simmons et al.   BLOOD

An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization

(2009) M. Jourdan et al.   BLOOD

Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma

(2009) E. Jost et al.   CANCER LETTERS

A Genomic Approach to Improve Prognosis and Predict Therapeutic Response in Chronic Lymphocytic Leukemia

(2009) D. R. Friedman et al.   CLINICAL CANCER RESEARCH

 -Catenin Small Interfering RNA Successfully Suppressed Progression of Multiple Myeloma in a Mouse Model

(2009) E. Ashihara et al.   CLINICAL CANCER RESEARCH

Wnt11 Promotes Osteoblast Maturation and Mineralization through R-spondin 2

(2009) Michael S. Friedman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples

(2009) Jacqueline E. Payton et al.   JOURNAL OF CLINICAL INVESTIGATION

Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia

(2009) K Giannopoulos et al.   LEUKEMIA

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Integrated Genomic Profiling of Chronic Lymphocytic Leukemia Identifies Subtypes of Deletion 13q14

(2008) P. Ouillette et al.   CANCER RESEARCH

Integration of genomic and gene expression data of childhood ALL without known aberrations identifies subgroups with specific genetic hallmarks

(2008) Silvia Bungaro et al.   GENES CHROMOSOMES & CANCER

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

(2008) R. G.W. Verhaak et al.   HAEMATOLOGICA

Stromal Gene Signatures in Large-B-Cell Lymphomas

(2008) G. Lenz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotype variability of two FAP families with an identical APC germline mutation at codon 1465: a potential modifier effect?

(2003) T Martin-Denavit et al.   CLINICAL GENETICS