Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors

(2016) Katsuhiko Mitachi et al.   ANALYTICAL BIOCHEMISTRY

UDP-GlcNAc pathway: Potential target for inhibitor discovery against M. tuberculosis

(2016) Chitra Rani et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis

(2016) Sandeep Thanna et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of KasA as the cellular target of an anti-tubercular scaffold

(2016) Katherine A. Abrahams et al.   Nature Communications

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

(2016) María Martínez-Hoyos et al.   EBioMedicine

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

(2015) Vadim Makarov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

(2015) Joaquín Rullas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis

(2015) Gaëlle S. Kolly et al.   JOURNAL OF BACTERIOLOGY

Lead selection and characterization of antitubercular compounds using the Nested Chemical Library

(2015) Anna Sipos et al.   TUBERCULOSIS

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase

(2015) Sarah M. Batt et al.   ACS Infectious Diseases

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

(2015) Grace Mugumbate et al.   PLoS One

Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F

(2014) Martina Hrast et al.   BIOORGANIC CHEMISTRY

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

(2014) V. Makarov et al.   EMBO Molecular Medicine

Discovery of a capuramycin analog that kills nonreplicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitors

(2014) Shajila Siricilla et al.   JOURNAL OF ANTIBIOTICS

Specificity of the Transport of Lipid II by FtsW inEscherichia coli

(2014) Tamimount Mohammadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA

(2014) Lourdes Encinas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of New Thiadiazole-Based Direct Inhibitors of Enoyl Acyl Carrier Protein Reductase (InhA) for the Treatment of Tuberculosis

(2014) Roman Šink et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway inMycobacterium tuberculosisusing conditional mutants

(2014) Gaëlle S. Kolly et al.   MOLECULAR MICROBIOLOGY

Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target

(2014) Sudagar S. Gurcha et al.   PLoS One

MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

(2014) L.-T. Sham et al.   SCIENCE

Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone

(2014) Anna E. Grzegorzewicz et al.   ACS Infectious Diseases

Kinetic mechanism and inhibition ofMycobacterium tuberculosisd-alanine:d-alanine ligase by the antibioticd-cycloserine

(2013) Gareth A. Prosser et al.   FEBS Journal

Inhibition of the First Step in Synthesis of the Mycobacterial Cell Wall Core, Catalyzed by the GlcNAc-1-phosphate Transferase WecA, by the Novel Caprazamycin Derivative CPZEN-45

(2013) Yoshimasa Ishizaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

(2013) Regina Wilson et al.   Nature Chemical Biology

Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU)

(2013) Anh Thu Tran et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

(2013) Katherine A. Abrahams et al.   PLoS One

Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis

(2013) Tulika Munshi et al.   PLoS One

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

(2013) Modesto J. Remuiñán et al.   PLoS One

Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

(2013) Thomas R. Ioerger et al.   PLoS One

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

(2013) S. A. Stanley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis

(2013) Gareth A. Prosser et al.   ACS Medicinal Chemistry Letters

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antigen 85C Inhibition Restricts Mycobacterium tuberculosis Growth through Disruption of Cord Factor Biosynthesis

(2012) Thulasi Warrier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of Mycobacterium tuberculosis l,d-Transpeptidase LdtMt1by Carbapenems and Cephalosporins

(2012) Vincent Dubée et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

targetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis

(2012) Karthik Raman et al.   BMC Systems Biology

MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria

(2012) Cristian Varela et al.   CHEMISTRY & BIOLOGY

Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds

(2012) Pan Pan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

(2012) Katherine A Sacksteder et al.   Future Microbiology

The Galactosamine Residue in Mycobacterial Arabinogalactan Is α-Linked

(2012) Wenjie Peng et al.   JOURNAL OF ORGANIC CHEMISTRY

Meropenem inhibits D,D-carboxypeptidase activity inMycobacterium tuberculosis

(2012) Pradeep Kumar et al.   MOLECULAR MICROBIOLOGY

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

(2012) Anna E Grzegorzewicz et al.   Nature Chemical Biology

Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria

(2012) Amrita K. Rana et al.   PLoS One

Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

(2012) S. M. Batt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of Functional Mycobacterial Arabinosyltransferase AftC Proteoliposome and Assessment of Decaprenylphosphorylarabinose Analogues as Arabinofuranosyl Donors

(2011) Jian Zhang et al.   ACS Chemical Biology

MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

(2011) Valentina La Rosa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Inhibitors of InhA Efficiently KillMycobacterium tuberculosisunder Aerobic and Anaerobic Conditions

(2011) Catherine Vilchèze et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design and synthesis of novel cell wall inhibitors of Mycobacterium tuberculosis GlmM and GlmU

(2011) Yongmeng Li et al.   CARBOHYDRATE RESEARCH

Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane

(2011) Tamimount Mohammadi et al.   EMBO JOURNAL

nvestigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster

(2011) P. Dianišková et al.   GENERAL PHYSIOLOGY AND BIOPHYSICS

ESI-MS Assay of M. tuberculosis Cell Wall Antigen 85 Enzymes Permits Substrate Profiling and Design of a Mechanism-Based Inhibitor

(2011) Conor S. Barry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The effect of MSMEG_6402 gene disruption on the cell wall structure of Mycobacterium smegmatis

(2011) Tao Jiang et al.   MICROBIAL PATHOGENESIS

Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branching

(2011) Arun K. Mishra et al.   MOLECULAR MICROBIOLOGY

The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module

(2011) Luke J. Alderwick et al.   PLoS Pathogens

Structure of theMycobacterium tuberculosisd-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine

(2010) John B. Bruning et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics

(2010) Amy E. Trunkfield et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic UDP-Furanoses as Potent Inhibitors of Mycobacterial Galactan Biogenesis

(2010) Pauline Peltier et al.   CHEMISTRY & BIOLOGY

Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG___4947 have WecA function and MSMEG__4947 is required for the growth of M. smegmatis

(2010) Yue Jin et al.   FEMS MICROBIOLOGY LETTERS

Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase

(2010) L. J. Alderwick et al.   GLYCOBIOLOGY

Redundant Function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis Cyclopropanation of Oxygenated Mycolates

(2010) D. Barkan et al.   JOURNAL OF BACTERIOLOGY

Biosynthetic Origin of the Galactosamine Substituent of Arabinogalactan inMycobacterium tuberculosis

(2010) Henrieta Škovierová et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of hotspot regions of MurB oxidoreductase enzyme using homology modeling, molecular dynamics and molecular docking techniques

(2010) Vivek Kumar et al.   JOURNAL OF MOLECULAR MODELING

A truncated lipoglycan from mycobacteria with altered immunological properties

(2010) H. L. Birch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of GlmU fromMycobacterium tuberculosis

(2009) Zhening Zhang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis

(2009) B. V. Nikonenko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

5-Benzylidenethiazolidin-4-ones as Multitarget Inhibitors of Bacterial Mur Ligases

(2009) Tihomir Tomašić et al.   ChemMedChem

AftD, a novel essential arabinofuranosyltransferase from mycobacteria

(2009) Henrieta Škovierová et al.   GLYCOBIOLOGY

Identification of a Polyprenylphosphomannosyl Synthase Involved in the Synthesis of Mycobacterial Mannosides

(2009) H. Scherman et al.   JOURNAL OF BACTERIOLOGY

New Insights into the Early Steps of Phosphatidylinositol Mannoside Biosynthesis in Mycobacteria

(2009) Marcelo E. Guerin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mycolyltransferase 85A, a putative drug target of Mycobacterium tuberculosis: Development of a novel assay and quantification of glycolipid-status of the mycobacterial cell wall

(2009) Ayssar A. Elamin et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Epimeric and amino disaccharide analogs as probes of an α-(1→6)-mannosyltransferase involved in mycobacterial lipoarabinomannanbiosynthesis

(2009) Pui Hang Tam et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases

(2009) Alistair K. Brown et al.   PLoS One

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

(2009) J.-E. Hugonnet et al.   SCIENCE

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

Synthesis of methyl 5-S-alkyl-5-thio-d-arabinofuranosides and evaluation of their antimycobacterial activity

(2008) Aditya K. Sanki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

(2008) Mamoun M. Alhamadsheh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Loss of a Mycobacterial Gene Encoding a Reductase Leads to an Altered Cell Wall Containing β-oxo- Mycolic Acid Analogs and Accumulation of Ketones

(2008) Apoorva Bhatt et al.   CHEMISTRY & BIOLOGY

Antigen 85C-mediated acyl-transfer between synthetic acyl donors and fragments of the arabinan

(2008) Aditya K. Sanki et al.   GLYCOCONJUGATE JOURNAL

Mutations in pimE Restore Lipoarabinomannan Synthesis and Growth in a Mycobacterium smegmatis lpqW Mutant

(2008) P. K. Crellin et al.   JOURNAL OF BACTERIOLOGY

The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by L,D-Transpeptidation

(2008) M. Lavollay et al.   JOURNAL OF BACTERIOLOGY

The Identification and Location of Succinyl Residues and the Characterization of the Interior Arabinan Region Allow for a Model of the Complete Primary Structure ofMycobacterium tuberculosisMycolyl Arabinogalactan

(2008) Suresh Bhamidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL

(2008) A. E. Grzegorzewicz et al.   MICROBIOLOGY-SGM

Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis

(2008) H. Huang et al.   MICROBIOLOGY-SGM

Identification of a novel α(1→6) mannopyranosyltransferase MptB fromCorynebacterium glutamicumby deletion of a conserved gene,NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant

(2008) Arun K. Mishra et al.   MOLECULAR MICROBIOLOGY

Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase in Escherichia coli

(2008) N. Ruiz   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoarabinomannan of Mycobacterium: Mannose capping by a multifunctional terminal mannosyltransferase

(2008) D. Kaur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis

(2007) Luke J. Alderwick et al.   PROTEIN EXPRESSION AND PURIFICATION