Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase

(2012) Inna V. Krieger et al.   CHEMISTRY & BIOLOGY

Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis

(2012) Myungsun Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel Inhibitors of InhA Efficiently KillMycobacterium tuberculosisunder Aerobic and Anaerobic Conditions

(2011) Catherine Vilchèze et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identifying Vulnerable Pathways in Mycobacterium tuberculosis by Using a Knockdown Approach

(2011) Paul Carroll et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Characterization of 7-amino-4-methylcoumarin as an effective antitubercular agent: structure–activity relationships

(2011) Rashmi Tandon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa

(2010) Thomas R Ioerger et al.   BMC GENOMICS

Screening for In Vitro Antimycobacterial Activity and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Study of 4-(arylamino)coumarin Derivatives

(2010) Vijay Virsdoia et al.   Chemical Biology & Drug Design

A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase fromMycobacterium tuberculosis

(2010) Sylvia R. Luckner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

The Dual Function of the Mycobacterium tuberculosis FadD32 Required for Mycolic Acid Biosynthesis

(2009) Mathieu Léger et al.   CHEMISTRY & BIOLOGY

Pseudomonas aeruginosa Infection of Zebrafish Involves both Host and Pathogen Determinants

(2009) A. E. Clatworthy et al.   INFECTION AND IMMUNITY

Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis

(2009) Pooja Arora et al.   Nature Chemical Biology

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

(2009) Subramaniam Ananthan et al.   TUBERCULOSIS

Insights into early mycobacterial pathogenesis from the zebrafish

(2008) Robin Lesley et al.   CURRENT OPINION IN MICROBIOLOGY

Confronting the scientific obstacles to global control of tuberculosis

(2008) Douglas B. Young et al.   JOURNAL OF CLINICAL INVESTIGATION

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE

Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis

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