Identification of KasA as the cellular target of an anti-tubercular scaffold
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Identification of KasA as the cellular target of an anti-tubercular scaffold
Authors
Keywords
-
Journal
Nature Communications
Volume 7, Issue -, Pages 12581
Publisher
Springer Nature
Online
2016-09-01
DOI
10.1038/ncomms12581
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria
- (2016) Jonathan A. G. Cox et al. Nature Microbiology
- Synthesis and biological activities of some new isonicotinic acid 2-(2-hydroxy-8-substituted-tricyclo[7.3.1.02.7]tridec-13-ylidene)-hydrazides
- (2015) Lilia Matei et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis
- (2015) Arundhati Maitra et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis
- (2015) Michael B. Harbut et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BioGPS: Navigating biological space to predict polypharmacology, off-targeting, and selectivity
- (2015) Lydia Siragusa et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria
- (2015) Wilfried Moreira et al. mBio
- Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery
- (2015) María Jose Rebollo-Lopez et al. PLoS One
- Ion Coalescence of Neutron Encoded TMT 10-Plex Reporter Ions
- (2014) Thilo Werner et al. ANALYTICAL CHEMISTRY
- In VitroandIn VivoActivities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis
- (2014) Ming Zhang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Modification of Rifamycin Polyketide Backbone Leads to Improved Drug Activity against Rifampicin-resistantMycobacterium tuberculosis
- (2014) Aeshna Nigam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target
- (2014) Sudagar S. Gurcha et al. PLoS One
- Future target-based drug discovery for tuberculosis?
- (2014) Bavesh Davandra Kana et al. TUBERCULOSIS
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis
- (2013) Lluís Ballell et al. ChemMedChem
- Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target fromMycobacterium Tuberculosis
- (2013) Johannes Schiebel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Measuring and Managing Ratio Compression for Accurate iTRAQ/TMT Quantification
- (2013) Mikhail M. Savitski et al. JOURNAL OF PROTEOME RESEARCH
- Advances in the development of new tuberculosis drugs and treatment regimens
- (2013) Alimuddin Zumla et al. NATURE REVIEWS DRUG DISCOVERY
- Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB
- (2013) Katherine A. Abrahams et al. PLoS One
- Synthesis, Antitubercular Activity and Mechanism of Resistance of Highly Effective Thiacetazone Analogues
- (2013) Geoffrey D. Coxon et al. PLoS One
- Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3
- (2013) Modesto J. Remuiñán et al. PLoS One
- Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?
- (2013) Robert C. Goldman TUBERCULOSIS
- Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
- (2011) Marcus Bantscheff et al. NATURE BIOTECHNOLOGY
- Large-scale phosphosite quantification in tissues by a spike-in SILAC method
- (2011) Mara Monetti et al. NATURE METHODS
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Fast Standardized Therapeutic-Efficacy Assay for Drug Discovery against Tuberculosis
- (2010) J. Rullas et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays
- (2010) Mikhail M. Savitski et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases
- (2009) Alistair K. Brown et al. PLoS One
- Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin
- (2009) Sylvia R. Luckner et al. STRUCTURE
- Loss of a Mycobacterial Gene Encoding a Reductase Leads to an Altered Cell Wall Containing β-oxo- Mycolic Acid Analogs and Accumulation of Ketones
- (2008) Apoorva Bhatt et al. CHEMISTRY & BIOLOGY
- Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
- (2008) Sarbjot Sachdeva et al. CHEMISTRY & BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now