Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU)

A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

(2013) Michael D. Urbaniak et al.   ACS Chemical Biology

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode

(2012) Nicholas A. Larsen et al.   BIOCHEMICAL JOURNAL

Elucidation ofMycobacterium tuberculosisType II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy

(2012) Anh Thu Tran et al.   ChemMedChem

Kinetic Modelling of GlmU Reactions – Prioritization of Reaction for Therapeutic Application

(2012) Vivek K. Singh et al.   PLoS One

The use of phosphate bioisosteres in medicinal chemistry and chemical biology

(2012) Thomas S. Elliott et al.   MedChemComm

Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

(2011) Nicholas P. West et al.   CHEMICAL COMMUNICATIONS

Current Status and Research Strategies in Tuberculosis Drug Development

(2011) Lynn G. Dover et al.   JOURNAL OF MEDICINAL CHEMISTRY

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

Chemical genetic strategy for targeting protein kinases based on covalent complementarity

(2011) A. L. Garske et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and Structural Characterization ofMycobacterium tuberculosisβ-Lactamase with the Carbapenems Ertapenem and Doripenem

(2010) Lee W. Tremblay et al.   BIOCHEMISTRY

The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin

(2010) Radhika Gupta et al.   NATURE MEDICINE

Structure and function of GlmU fromMycobacterium tuberculosis

(2009) Zhening Zhang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure ofN-acetylglucosamine-1-phosphate uridyltransferase (GlmU) fromMycobacterium tuberculosisin a cubic space group

(2009) Sunil Kumar Verma et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

(2009) J.-E. Hugonnet et al.   SCIENCE

Inhibitors of UDP-Galactopyranose Mutase Thwart Mycobacterial Growth

(2008) Emily C. Dykhuizen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site

(2008) Igor Mochalkin et al.   PROTEIN SCIENCE