Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics
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Title
Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics
Authors
Keywords
HIV, Antiretroviral therapy, Neurotoxicity, Brain, HIV-associated neurocognitive disorder, CYP450
Journal
NEUROTOXICITY RESEARCH
Volume 30, Issue 4, Pages 677-697
Publisher
Springer Nature
Online
2016-06-30
DOI
10.1007/s12640-016-9646-0
References
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Note: Only part of the references are listed.- HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance
- (2016) Pornpun Vivithanaporn et al. AIDS
- HIV Non-Nucleoside Reverse Transcriptase Inhibitor Efavirenz Reduces Neural Stem Cell Proliferation in Vitro and in Vivo
- (2016) Jingji Jin et al. CELL TRANSPLANTATION
- ABC transporters at the blood–brain barrier
- (2016) Anne Mahringer et al. Expert Opinion on Drug Metabolism & Toxicology
- Cerebral white matter integrity during primary HIV infection
- (2015) Patrick W. Wright et al. AIDS
- Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage
- (2015) Ana B. Sanchez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Outcome of neuropsychiatric symptoms related to an antiretroviral drug following its substitution by nevirapine: the RELAX study
- (2015) E Pedrol et al. HIV MEDICINE
- Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines
- (2015) Haryes A. Funes et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders
- (2015) Brigid K. Jensen et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Central nervous system penetration effectiveness of antiretroviral drugs and neuropsychological impairment in the Ontario HIV Treatment Network Cohort Study
- (2015) Adriana Carvalhal et al. JOURNAL OF NEUROVIROLOGY
- Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients
- (2015) Qing Ma et al. JOURNAL OF NEUROVIROLOGY
- The Roles of HIV-1 Proteins and Antiretroviral Drug Therapy in HIV-1-Associated Endothelial Dysfunction
- (2015) Erik R. Kline et al. JOURNAL OF INVESTIGATIVE MEDICINE
- Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment
- (2014) Edana Cassol et al. AIDS
- Overexpression of mitochondrial antioxidant manganese superoxide dismutase (MnSOD) provides protection against AZT- or 3TC-induced endothelial dysfunction
- (2014) Mitzi Glover et al. ANTIVIRAL RESEARCH
- Impact of darunavir, atazanavir and lopinavir boosted with ritonavir on cultured human endothelial cells: beneficial effect of pravastatin
- (2014) Martine Auclair et al. ANTIVIRAL THERAPY
- Cytokine secretion from brain macrophages infected with human immunodeficiency virus in vitro and treated with raltegravir
- (2014) Erick T Tatro et al. BMC INFECTIOUS DISEASES
- Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study
- (2014) R. K. Heaton et al. CLINICAL INFECTIOUS DISEASES
- Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz
- (2014) A. Blas-Garcia et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Verbal memory declines more rapidly with age in HIV infected versus uninfected adults
- (2014) Talia R. Seider et al. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
- Involvement of Nitric Oxide in the Mitochondrial Action of Efavirenz: A Differential Effect on Neurons and Glial Cells
- (2014) Nadezda Apostolova et al. JOURNAL OF INFECTIOUS DISEASES
- Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum
- (2014) Sean G. Kelly et al. JOURNAL OF NEUROVIROLOGY
- Brain viral burden, neuroinflammation and neurodegeneration in HAART-treated HIV positive injecting drug users
- (2014) Donald B. Smith et al. JOURNAL OF NEUROVIROLOGY
- Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system
- (2014) Cagla Akay et al. JOURNAL OF NEUROVIROLOGY
- Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions
- (2014) E. C. Caniglia et al. NEUROLOGY
- Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages
- (2014) Xiaoxuan Zhang et al. PLoS One
- Long-Term Exposure of Mice to Nucleoside Analogues Disrupts Mitochondrial DNA Maintenance in Cortical Neurons
- (2014) Yulin Zhang et al. PLoS One
- Efavirenz Promotes β-Secretase Expression and Increased Aβ1-40,42 via Oxidative Stress and Reduced Microglial Phagocytosis: Implications for HIV Associated Neurocognitive Disorders (HAND)
- (2014) Lecia A. M. Brown et al. PLoS One
- Pharmacokinetics of Phase I Nevirapine Metabolites following a Single Dose and at Steady State
- (2013) Patty Fan-Havard et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents
- (2013) Yumi Hashiguchi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Neurological and Psychiatric Adverse Effects of Antiretroviral Drugs
- (2013) Michael S. Abers et al. CNS DRUGS
- In Vitro Analysis and Quantitative Prediction of Efavirenz Inhibition of Eight Cytochrome P450 (CYP) Enzymes: Major Effects on CYPs 2B6, 2C8, 2C9 and 2C19
- (2013) Cong Xu et al. Drug Metabolism and Pharmacokinetics
- Improved neurocognitive test performance in both arms of the SMART study: impact of practice effect
- (2013) Birgit Grund et al. JOURNAL OF NEUROVIROLOGY
- Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy
- (2013) Assawin Gongvatana et al. JOURNAL OF NEUROVIROLOGY
- Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene
- (2013) A Persson et al. MOLECULAR PSYCHIATRY
- Impact of pharmacogenetics on CNS side effects related to efavirenz
- (2013) Almudena Sánchez Martín et al. PHARMACOGENOMICS
- Marked increase of the astrocytic marker S100B in the cerebrospinal fluid of HIV-infected patients on LPV/r-monotherapy
- (2012) Renaud A. Du Pasquier et al. AIDS
- Brain injury caused by HIV protease inhibitors: Role of lipodystrophy and insulin resistance
- (2012) Sunita Gupta et al. ANTIVIRAL RESEARCH
- Psychological stress is associated with high levels of IL-6 in HIV-1 infected individuals on effective combined antiretroviral treatment
- (2012) Carmina R. Fumaz et al. BRAIN BEHAVIOR AND IMMUNITY
- CSF Penetration by Antiretroviral Drugs
- (2012) Christine Eisfeld et al. CNS DRUGS
- Antiretroviral neurotoxicity
- (2012) Kevin Robertson et al. JOURNAL OF NEUROVIROLOGY
- Impact of HIV and aging on neuropsychological function
- (2012) Lauren A. Wendelken et al. JOURNAL OF NEUROVIROLOGY
- Randomized, phase 2 evaluation of two single-tablet regimens elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate for the initial treatment of HIV infection
- (2011) Calvin Cohen et al. AIDS
- TNFα is involved in neuropathic pain induced by nucleoside reverse transcriptase inhibitor in rats
- (2011) Xuexing Zheng et al. BRAIN BEHAVIOR AND IMMUNITY
- Clinical Pharmacokinetic and Pharmacodynamic Profile of the HIV Integrase Inhibitor Elvitegravir
- (2011) Srinivasan Ramanathan et al. CLINICAL PHARMACOKINETICS
- Long-Term Safety from the Raltegravir Clinical Development Program
- (2011) Hedy Teppler et al. CURRENT HIV RESEARCH
- Protease inhibitor monotherapy and the CNS: peace of mind?
- (2011) I. Perez-Valero et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Modulatory effects of the CCR5 antagonist maraviroc on microglial pro-inflammatory activation elicited by gp120
- (2011) Lucia Lisi et al. JOURNAL OF NEUROCHEMISTRY
- Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism
- (2011) E. A. Eugenin et al. JOURNAL OF NEUROSCIENCE
- Brain-derived neurotrophic factor modulates antiretroviral-induced mechanical allodynia in the mouse
- (2011) Cynthia L. Renn et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Antiretroviral therapy CNS penetration and HIV-1-associated CNS disease
- (2011) L. Garvey et al. NEUROLOGY
- Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders
- (2011) Brian Giunta et al. Molecular Brain
- Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders
- (2011) Alejandra Borjabad et al. PLoS Pathogens
- Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
- (2010) Samanta Simioni et al. AIDS
- Oral uridine supplementation antagonizes the peripheral neuropathy and encephalopathy induced by antiretroviral nucleoside analogues
- (2010) Nils Venhoff et al. AIDS
- Effects of central nervous system antiretroviral penetration on cognitive functioning in the ALLRT cohort
- (2010) Marlene Smurzynski et al. AIDS
- Clinical perspective on antiretroviral drug–drug interactions with the non-nucleoside reverse transcriptase inhibitor etravirine
- (2010) Thomas N Kakuda et al. ANTIVIRAL THERAPY
- Ubisol-AquaTM: Coenzyme Q10 Prevents Antiretroviral Toxic Neuropathy in an In Vitro Model
- (2010) Catherine L. Cherry et al. CURRENT HIV RESEARCH
- Enhancing the Delivery of Anti Retroviral Drug “Saquinavir” Across the Blood Brain Barrier Using Nanoparticles
- (2010) Supriya D. Mahajan et al. CURRENT HIV RESEARCH
- Alcohol consumption enhances antiretroviral painful peripheral neuropathy by mitochondrial mechanisms
- (2010) Luiz F. Ferrari et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood–brain barrier endothelial cells
- (2010) Kalyan Reddy Manda et al. FREE RADICAL BIOLOGY AND MEDICINE
- CYP2C19 Genetic Variants Affect Nelfinavir Pharmacokinetics and Virologic Response in HIV-1–Infected Children Receiving Highly Active Antiretroviral Therapy
- (2010) Akihiko Saitoh et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Chronic exposure to nicotine and saquinavir decreases endothelial Notch-4 expression and disrupts blood-brain barrier integrity
- (2010) Vamshi K. Manda et al. JOURNAL OF NEUROCHEMISTRY
- Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage
- (2010) Rafael F. Bressani et al. Nanotoxicology
- Cardiovascular risk factors associated with lower baseline cognitive performance in HIV-positive persons
- (2010) E. J. Wright et al. NEUROLOGY
- Neurocognitive effects of treatment interruption in stable HIV-positive patients in an observational cohort
- (2010) K. R. Robertson et al. NEUROLOGY
- HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
- (2010) R. K. Heaton et al. NEUROLOGY
- Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury
- (2010) S. Nag et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Progressive Mitochondrial Compromise in Brains and Livers of Primates Exposed In Utero to Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
- (2010) Rao L. Divi et al. TOXICOLOGICAL SCIENCES
- Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs
- (2009) Puneet Sharma et al. ADVANCED DRUG DELIVERY REVIEWS
- Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance
- (2009) Christina M Marra et al. AIDS
- Roles and Mechanisms of Human Immunodeficiency Virus Protease Inhibitor Ritonavir and Other Anti-Human Immunodeficiency Virus Drugs in Endothelial Dysfunction of Porcine Pulmonary Arteries and Human Pulmonary Artery Endothelial Cells
- (2009) Xinwen Wang et al. AMERICAN JOURNAL OF PATHOLOGY
- Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3
- (2009) Rajgopal Govindarajan et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Non-nucleoside reverse transcriptase inhibitor efavirenz increases monolayer permeability of human coronary artery endothelial cells
- (2009) Md Saha Jamaluddin et al. ATHEROSCLEROSIS
- Drug Interactions with New and Investigational Antiretrovirals
- (2009) Kevin C. Brown et al. CLINICAL PHARMACOKINETICS
- PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities
- (2009) Wen Huang et al. FASEB JOURNAL
- The blood–brain barrier and immune function and dysfunction
- (2009) William A. Banks et al. NEUROBIOLOGY OF DISEASE
- Structure and function of the blood–brain barrier
- (2009) N. Joan Abbott et al. NEUROBIOLOGY OF DISEASE
- Neuropsychological Functioning and Antiretroviral Treatment in HIV/AIDS: A Review
- (2009) Lucette A. Cysique et al. NEUROPSYCHOLOGY REVIEW
- The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs
- (2009) Sarah Shugarts et al. PHARMACEUTICAL RESEARCH
- The complexities of antiretroviral drug–drug interactions: role of ABC and SLC transporters
- (2009) Olena Kis et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Exacerbation of depression associated with starting raltegravir: a report of four cases
- (2008) Marianne Harris et al. AIDS
- A Report on the Effect of Commencing Enfuvirtide on Peripheral Neuropathy
- (2008) Catherine L. Cherry et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy
- (2008) Ronald J. Ellis et al. ANNALS OF NEUROLOGY
- Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir
- (2008) Aline Grigorian et al. BMC NEUROSCIENCE
- Maraviroc:in vitroassessment of drug-drug interaction potential
- (2008) Ruth Hyland et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
- (2008) Samantha Abel et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Long-Term Exposure to AZT, but not d4T, Increases Endothelial Cell Oxidative Stress and Mitochondrial Dysfunction
- (2008) Erik R. Kline et al. Cardiovascular Toxicology
- CYP2B6: New Insights into a Historically Overlooked Cytochrome P450 Isozyme
- (2008) Hongbing Wang et al. CURRENT DRUG METABOLISM
- Efavirenz Induces CYP2B6-Mediated Hydroxylation of Bupropion in Healthy Subjects
- (2008) Sarah M Robertson et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Neurodegeneration and Ageing in the HAART Era
- (2008) Bruce J. Brew et al. Journal of Neuroimmune Pharmacology
- Effects of the HIV treatment drugs nevirapine and efavirenz on brain creatine kinase activity
- (2008) Emilio L. Streck et al. METABOLIC BRAIN DISEASE
- The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
- (2008) Berislav V. Zlokovic NEURON
- Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
- (2008) S. Palmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis
- (2007) Marcus Kaul Frontiers in Bioscience-Landmark
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