Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

NeuroAIDS: An Evolving Epidemic

(2014) Christopher Power et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Mg supplementation attenuates ritonavir-induced hyperlipidemia, oxidative stress, and cardiac dysfunction in rats

(2013) I. Tong Mak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The maladaptive effects of HIV protease inhibitors (lopinavir/ritonavir) on the rat heart

(2013) Kathleen M.S.E. Reyskens et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardio-Metabolic Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir)

(2013) Kathleen M. S. E. Reyskens et al.   PLoS One

Antiretroviral neurotoxicity

(2012) Kevin Robertson et al.   JOURNAL OF NEUROVIROLOGY

Evidence for Time-Dependent Interactions between Ritonavir and Lopinavir/Ritonavir Plasma Levels Following P-Glycoprotein Inhibition in Sprague-Dawley Rats

(2011) Michael du Plooy et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Current understanding of HIV-associated neurocognitive disorders pathogenesis

(2011) Patrick Gannon et al.   CURRENT OPINION IN NEUROLOGY

Dimethyl Fumarate, an Immune Modulator and Inducer of the Antioxidant Response, Suppresses HIV Replication and Macrophage-Mediated Neurotoxicity: A Novel Candidate for HIV Neuroprotection

(2011) Stephanie A. Cross et al.   JOURNAL OF IMMUNOLOGY

Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus

(2011) Michelle M Mielke et al.   JOURNAL OF NEUROVIROLOGY

Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity

(2011) C. Akay et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Multiple Sclerosis Therapeutic Pipeline: Opportunities and Challenges

(2011) Stephen Krieger   MOUNT SINAI JOURNAL OF MEDICINE

Phase III success for Biogen's oral multiple sclerosis therapy

(2011)   NATURE REVIEWS DRUG DISCOVERY

Antiretroviral therapy CNS penetration and HIV-1-associated CNS disease

(2011) L. Garvey et al.   NEUROLOGY

Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration

(2011) Michael G. White et al.   NEUROSCIENCE RESEARCH

Resveratrol protects against protease inhibitor-induced reactive oxygen species production, reticulum stress and lipid raft perturbation

(2010) Olivia Touzet et al.   AIDS

Effects of central nervous system antiretroviral penetration on cognitive functioning in the ALLRT cohort

(2010) Marlene Smurzynski et al.   AIDS

HIV and SIV Induce Alterations in CNS CaMKII Expression and Activation

(2010) Ravi G. Gupta et al.   AMERICAN JOURNAL OF PATHOLOGY

Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice

(2010) Paul J. Pistell et al.   ANTIVIRAL RESEARCH

Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia

(2010) Jeffrey F. Waring et al.   ARCHIVES OF TOXICOLOGY

A Pharmacokinetic Model for Evaluating the Impact of Hepatic and Intestinal First-Pass Loss of Saquinavir in the Rat

(2010) R. Lledo-Garcia et al.   DRUG METABOLISM AND DISPOSITION

HIV‐1 Viral Escape in Cerebrospinal Fluid of Subjects on Suppressive Antiretroviral Treatment

(2010) Arvid Edén et al.   JOURNAL OF INFECTIOUS DISEASES

Simian Immunodeficiency Virus–Infected Macaques Treated with Highly Active Antiretroviral Therapy Have Reduced Central Nervous System Viral Replication and Inflammation but Persistence of Viral DNA

(2010) M. Christine Zink et al.   JOURNAL OF INFECTIOUS DISEASES

Nicotine and cotinine increases the brain penetration of saquinavir in rat

(2010) Vamshi K. Manda et al.   JOURNAL OF NEUROCHEMISTRY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

E2F1 localizes predominantly to neuronal cytoplasm and fails to induce expression of its transcriptional targets in human immunodeficiency virus-induced neuronal damage

(2010) Ying Wang et al.   NEUROSCIENCE LETTERS

Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats

(2010) Yi Yang et al.   VETERINARY JOURNAL

Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance

(2009) Christina M Marra et al.   AIDS

Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action

(2009) Caroline Bazzoli et al.   CLINICAL PHARMACOKINETICS

Changes in Cognition During Antiretroviral Therapy: Comparison of 2 Different Ranking Systems to Measure Antiretroviral Drug Efficacy on HIV-Associated Neurocognitive Disorders

(2009) Valerio Tozzi et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The Mitochondrial ATP-Sensitive Potassium Channel Blocker 5-Hydroxydecanoate Inhibits Toxicity of 6-Hydroxydopamine on Dopaminergic Neurons

(2009) J. Rodriguez-Pallares et al.   NEUROTOXICITY RESEARCH

Raltegravir Cerebrospinal Fluid Concentrations in HIV-1 Infection

(2009) Aylin Yilmaz et al.   PLoS One

Validation of the CNS Penetration-Effectiveness Rank for Quantifying Antiretroviral Penetration Into the Central Nervous System

(2008) Scott Letendre   ARCHIVES OF NEUROLOGY

The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer’s Disease: A Foreseeable Medical Challenge in Post-HAART Era

(2008) Jiqing Xu et al.   Journal of Neuroimmune Pharmacology

Combination antiretroviral therapy modulates the blood oxygen level–dependent amplitude in human immunodeficiency virus–seropositive patients

(2008) Beau M Ances et al.   JOURNAL OF NEUROVIROLOGY