Efavirenz Promotes β-Secretase Expression and Increased Aβ1-40,42 via Oxidative Stress and Reduced Microglial Phagocytosis: Implications for HIV Associated Neurocognitive Disorders (HAND)

ER stress in human hepatic cells treated with Efavirenz: Mitochondria again

(2013) Nadezda Apostolova et al.   JOURNAL OF HEPATOLOGY

Risk Factors for β-Amyloid Deposition in Healthy Aging

(2013) Karen M. Rodrigue et al.   JAMA Neurology

Profile of stress and toxicity gene expression in human hepatic cells treated with Efavirenz

(2012) Leysa J. Gomez-Sucerquia et al.   ANTIVIRAL RESEARCH

11C-PiB Imaging of Human Immunodeficiency Virus–Associated Neurocognitive Disorder

(2012) Beau M. Ances   ARCHIVES OF NEUROLOGY

Twenty Years of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Time to Reevaluate their Toxicity

(2012) A. Blas-Garcia et al.   CURRENT MEDICINAL CHEMISTRY

Oxidative Stress and Mitochondrial Impairment After Treatment with Anti-HIV Drugs: Clinical Implications

(2012) Ana Blas-Garcia et al.   CURRENT PHARMACEUTICAL DESIGN

Cerebrospinal Fluid Profiles and Prospective Course and Outcome in Patients With Amnestic Mild Cognitive Impairment

(2011) Ozioma C. Okonkwo   ARCHIVES OF NEUROLOGY

Autophagy as a rescue mechanism in Efavirenz-induced mitochondrial dysfunction: A lesson from hepatic cells

(2011) Nadezda Apostolova et al.   Autophagy

Mitochondrial Toxicity in HAART: An Overview of In Vitro Evidence

(2011) Nadezda Apostolova et al.   CURRENT PHARMACEUTICAL DESIGN

Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy

(2011) Nadezda Apostolova et al.   HEPATOLOGY

Efavirenz associated with cognitive disorders in otherwise asymptomatic HIV-infected patients

(2011) N. Ciccarelli et al.   NEUROLOGY

Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition

(2011) Nadezda Apostolova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Antiretroviral drug supply challenges in the era of scaling up ART in Malawi

(2011) Erik J Schouten et al.   Journal of the International AIDS Society

Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders

(2011) Brian Giunta et al.   Molecular Brain

A phase IV, double-blind, multicentre, randomized, placebo-controlled, pilot study to assess the feasibility of switching individuals receiving efavirenz with continuing central nervous system adverse events to etravirine

(2010) Laura Waters et al.   AIDS

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

In Utero Exposure of Female CD-1 Mice to AZT and/or 3TC: II. Persistence of Functional Alterations in Cardiac Tissue

(2010) Salina M. Torres et al.   Cardiovascular Toxicology

Does Choice of Combination Antiretroviral Therapy (cART) Alter Changes in Cerebral Function Testing after 48 Weeks in Treatment‐Naive, HIV‐1–Infected Individuals Commencing cART? A Randomized, Controlled Study

(2010) Alan Winston et al.   CLINICAL INFECTIOUS DISEASES

Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood–brain barrier endothelial cells

(2010) Kalyan Reddy Manda et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells

(2010) Ana Blas-García et al.   HEPATOLOGY

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

Dream changes following initiation of efavirenz treatment

(2010) María Velasco et al.   MEDICINA CLINICA

Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: A case-control study

(2010) B. M. Ances et al.   NEUROLOGY

Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice

(2010) Brian Giunta et al.   NEUROSCIENCE LETTERS

Nuclear Factor-Kappa B Family Member RelB Inhibits Human Immunodeficiency Virus-1 Tat-Induced Tumor Necrosis Factor-Alpha Production

(2010) Michelle Kiebala et al.   PLoS One

Decreased cerebrospinal fluid Aβ42correlates with brain atrophy in cognitively normal elderly

(2009) Anne M. Fagan et al.   ANNALS OF NEUROLOGY

Beta Amyloid in Alzheimer's Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid

(2009) Timo Grimmer et al.   BIOLOGICAL PSYCHIATRY

Amyloid and tau cerebrospinal fluid biomarkers in HIV infection

(2009) Magnus Gisslén et al.   BMC Neurology

Cerebrospinal fluid tau and ptau181increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

(2009) Anne M. Fagan et al.   EMBO Molecular Medicine

Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients

(2009) Cristian L. Achim et al.   Journal of Neuroimmune Pharmacology

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease

(2009) D. B. Clifford et al.   NEUROLOGY

Anti-HIV Drugs Nevirapine and Efavirenz Affect Anxiety-Related Behavior and Cognitive Performance in Mice

(2009) Pedro R. T. Romão et al.   NEUROTOXICITY RESEARCH

Antiviral efficacy, tolerability and pharmacokinetics of efavirenz in an unselected cohort of HIV-infected children

(2008) U. Wintergerst et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Initial Treatment for HIV Infection — An Embarrassment of Riches

(2008) Bernard Hirschel et al.   NEW ENGLAND JOURNAL OF MEDICINE