标题
mTOR Signaling in Parkinson’s Disease
作者
关键词
mTOR, Parkinson’s disease, Apoptosis, α-Synuclein, Oxidative stress
出版物
NEUROMOLECULAR MEDICINE
Volume 19, Issue 1, Pages 1-10
出版商
Springer Nature
发表日期
2016-06-05
DOI
10.1007/s12017-016-8417-7
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
- (2016) Yan Chen Shang et al. Aging-US
- Programming Apoptosis and Autophagy with Novel Approaches for Diabetes Mellitus
- (2015) Kenneth Maiese CURRENT NEUROVASCULAR RESEARCH
- Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease
- (2015) Zaijun Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pharmacologic agents targeting autophagy
- (2015) Helin Vakifahmetoglu-Norberg et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
- (2015) Benjamin Dehay et al. LANCET NEUROLOGY
- Compromised autophagy and neurodegenerative diseases
- (2015) Fiona M. Menzies et al. NATURE REVIEWS NEUROSCIENCE
- Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease
- (2015) Ulrika Nordström et al. NEUROBIOLOGY OF DISEASE
- mTOR in Brain Physiology and Pathologies
- (2015) Joël Bockaert et al. PHYSIOLOGICAL REVIEWS
- Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
- (2015) Changyoun Kim et al. Cell Reports
- Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease
- (2015) Anke A. Dijkstra et al. PLoS One
- High Glucose Condition Induces Autophagy in Endothelial Progenitor Cells Contributing to Angiogenic Impairment
- (2014) Kyeong-A Kim et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells
- (2014) Hee Ju Kim et al. Biomolecules & Therapeutics
- Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
- (2014) Yijiao Xu et al. CELLULAR SIGNALLING
- Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model
- (2014) Ji-Young Ha et al. JOURNAL OF NEUROCHEMISTRY
- Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway
- (2014) Lei-Lei Chen et al. Journal of Neuroimmune Pharmacology
- Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives
- (2014) Anthony H V Schapira et al. LANCET
- Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway
- (2014) Jia-Qing Yan et al. MOLECULAR NEUROBIOLOGY
- Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries
- (2014) Venkata Prasuja Nakka et al. MOLECULAR NEUROBIOLOGY
- PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways
- (2014) Xiaoxing Xiong et al. NEUROBIOLOGY OF DISEASE
- Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis
- (2014) Qian Zhou et al. TOXICOLOGICAL SCIENCES
- Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson’s disease
- (2014) J Romaní-Aumedes et al. Cell Death & Disease
- Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation
- (2014) B I Pérez-Revuelta et al. Cell Death & Disease
- Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes
- (2014) Yu-Mi Lim et al. Nature Communications
- Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice
- (2014) Arnaud Francois et al. Molecular Brain
- mTOR in aging, metabolism, and cancer
- (2013) Marion Cornu et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Parkinson disease: from pathology to molecular disease mechanisms
- (2013) David T. Dexter et al. FREE RADICAL BIOLOGY AND MEDICINE
- The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease
- (2013) Xian-Si Zeng et al. FREE RADICAL BIOLOGY AND MEDICINE
- Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
- (2013) Sarah Ciccone et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells
- (2013) An-Guo Wu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy
- (2013) Tian-Fang Jiang et al. Journal of Neuroimmune Pharmacology
- Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor
- (2013) Sajjad Hussain et al. MOLECULAR AND CELLULAR BIOLOGY
- Neurodegeneration in Parkinson's Disease: Interactions of Oxidative Stress, Tryptophan Catabolites and Depression with Mitochondria and Sirtuins
- (2013) George Anderson et al. MOLECULAR NEUROBIOLOGY
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Guide to Neurotoxic Animal Models of Parkinson's Disease
- (2013) K. Tieu Cold Spring Harbor Perspectives in Medicine
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Wnt1 Inducible Signaling Pathway Protein 1 (WISP1) Targets PRAS40 to Govern β-Amyloid Apoptotic Injury of Microglia
- (2012) Yan Chen Shang et al. CURRENT NEUROVASCULAR RESEARCH
- Mapping Autophagy on to Your Metabolic Radar
- (2012) E. Yamada et al. DIABETES
- Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes
- (2012) C. He et al. DIABETES
- Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment
- (2012) Jason R. Cannon et al. EXPERIMENTAL NEUROLOGY
- Mechanistic Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation Is Governed by Competition between Substrates for Interaction with Raptor
- (2012) Michael D. Dennis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling
- (2012) Senthil Selvaraj et al. JOURNAL OF CLINICAL INVESTIGATION
- Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1
- (2012) X. Lin et al. JOURNAL OF NEUROSCIENCE
- Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells
- (2012) Jezabel Rodríguez-Blanco et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity
- (2012) Jae-Kyo Jeong et al. NEUROSCIENCE RESEARCH
- Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways
- (2012) Jonathan Wills et al. PLoS One
- Differential Effects of UCHL1 Modulation on Alpha-Synuclein in PD-Like Models of Alpha-Synucleinopathy
- (2012) Anna E. Cartier et al. PLoS One
- PRAS40 Is an Integral Regulatory Component of Erythropoietin mTOR Signaling and Cytoprotection
- (2012) Zhao Zhong Chong et al. PLoS One
- mTOR: on target for novel therapeutic strategies in the nervous system
- (2012) Kenneth Maiese et al. TRENDS IN MOLECULAR MEDICINE
- Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration
- (2011) Sang Ryong Kim et al. ANNALS OF NEUROLOGY
- Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing
- (2011) Valerie Cullen et al. ANNALS OF NEUROLOGY
- Parkinson's Disease: Genetics and Pathogenesis
- (2011) Joshua M. Shulman et al. Annual Review of Pathology-Mechanisms of Disease
- Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
- (2011) Laura R. Pearce et al. BIOCHEMICAL JOURNAL
- mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
- (2011) P. Gulhati et al. CANCER RESEARCH
- mTOR complex 2 signaling and functions
- (2011) Won Jun Oh et al. CELL CYCLE
- Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions
- (2011) Laura Magri et al. Cell Stem Cell
- Proline-rich Akt substrate of 40kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway
- (2011) Haitao Wang et al. CELLULAR SIGNALLING
- Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease
- (2011) D. F.F. Silva et al. Current Alzheimer Research
- NMNAT Expression and its Relation to NAD Metabolism
- (2011) H. N. Jayaram et al. CURRENT MEDICINAL CHEMISTRY
- Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia
- (2011) Yan Chen Shang et al. CURRENT NEUROVASCULAR RESEARCH
- Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
- (2011) Andrii Domanskyi et al. FASEB JOURNAL
- Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives
- (2011) Zelda H. Cheung et al. JOURNAL OF NEUROCHEMISTRY
- Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling
- (2011) C. Rieker et al. JOURNAL OF NEUROSCIENCE
- Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia
- (2011) Srinivasa Subramaniam et al. NATURE NEUROSCIENCE
- Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains
- (2011) Rajeswara Babu Mythri et al. NEUROCHEMICAL RESEARCH
- FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models
- (2011) X.-Q. Bao et al. NEUROSCIENCE
- Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network
- (2011) Baoshan Xu et al. PLoS One
- Lysosomal membrane permeabilization in Parkinson disease
- (2010) Miquel Vila et al. Autophagy
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- Oxidative stress: Biomarkers and novel therapeutic pathways
- (2010) Kenneth Maiese et al. EXPERIMENTAL GERONTOLOGY
- Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death
- (2010) Long Chen et al. FREE RADICAL BIOLOGY AND MEDICINE
- A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1
- (2010) Hitoshi Murata et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease
- (2010) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells
- (2010) Long Chen et al. LABORATORY INVESTIGATION
- Autophagy gone awry in neurodegenerative diseases
- (2010) Esther Wong et al. NATURE NEUROSCIENCE
- Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
- (2010) Leslie Crews et al. PLoS One
- Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein
- (2009) Wai Haung Yu et al. AMERICAN JOURNAL OF PATHOLOGY
- Rapamycin inhibits mTORC1, but not completely
- (2009) Carson C. Thoreen et al. Autophagy
- Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors
- (2009) J. Huang et al. CANCER RESEARCH
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- The role of local protein synthesis and degradation in axon regeneration
- (2009) Laura F. Gumy et al. EXPERIMENTAL NEUROLOGY
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death
- (2009) Kyou-Chan Choi et al. JOURNAL OF NEUROCHEMISTRY
- RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation
- (2009) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
- (2009) Luke S Tain et al. NATURE NEUROSCIENCE
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
- (2009) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Rapamycin protects against rotenone-induced apoptosis through autophagy induction
- (2009) T. Pan et al. NEUROSCIENCE
- Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
- (2009) E. Santini et al. Science Signaling
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- Targets for neuroprotection in Parkinson's disease
- (2008) Talene A. Yacoubian et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
- (2008) Yuzuru Imai et al. EMBO JOURNAL
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis
- (2008) Long Chen et al. JOURNAL OF NEUROCHEMISTRY
- The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2
- (2008) J. Huang et al. MOLECULAR AND CELLULAR BIOLOGY
- Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
- (2008) Tianhong Pan et al. NEUROBIOLOGY OF DISEASE
- Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
- (2008) A. Y. Choo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of mTOR in physiology and pathology of the nervous system
- (2007) Lukasz Swiech et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started