Peripheral Mitochondrial Dysfunction: A Potential Contributor to the Development of Metabolic Disorders and Alzheimer’s Disease

Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial

(2023) Burak Yulug et al.   Translational Neurodegeneration

Implications of Glycosylation in Alzheimer’s Disease

(2021) Henriette Haukedal et al.   Frontiers in Neuroscience

The function of SUMOylation and its crucial roles in the development of neurological diseases

(2021) Xu Chen et al.   FASEB JOURNAL

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

(2021) Afzal Misrani et al.   Frontiers in Aging Neuroscience

Mitochondrial fusion and fission: The fine‐tune balance for cellular homeostasis

(2021) Mary Adebayo et al.   FASEB JOURNAL

Mitochondrial dysfunctions in neurodegenerative diseases: role in disease pathogenesis, strategies for analysis and therapeutic prospects

(2021) Stephana Carelli et al.   Neural Regeneration Research

Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer’s Disease: Targeting Mitochondria for Diagnosis and Prevention

(2020) Yunhua Peng et al.   ANTIOXIDANTS & REDOX SIGNALING

Association of combination statin and antihypertensive therapy with reduced Alzheimer’s disease and related dementia risk

(2020) Douglas Barthold et al.   PLoS One

The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease

(2020) Giacomo Monzio Compagnoni et al.   MOLECULAR NEUROBIOLOGY

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

The rise and rise of mitochondrial DNA mutations

(2020) Conor Lawless et al.   Open Biology

Mitochondrial Bioenergetics and Dynamics in Secretion Processes

(2020) Jennyfer Martínez et al.   Frontiers in Endocrinology

Truncation of tau selectively facilitates its pathological activities

(2020) Jianlan Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction in metabolic syndrome

(2020) Pankaj Prasun   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms

(2020) Xiaowen Huang et al.   CNS Neuroscience & Therapeutics

Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation

(2020) Hossein Ashrafian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis

(2019) Mark V Pinti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Treatment Combinations for Alzheimer’s Disease: Current And Future Pharmacotherapy Options

(2019) Jeffrey L. Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease

(2019) James A R Nicoll et al.   BRAIN

Mitochondrial Dysfunctions: A Thread Sewing Together Alzheimer’s Disease, Diabetes, and Obesity

(2019) Giulia Rigotto et al.   Oxidative Medicine and Cellular Longevity

Mitochondria in Health and Disease

(2019) Sarah J. Annesley et al.   Cells

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance

(2019) Ying Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

New Evidence of Mitochondria Dysfunction in the Female Alzheimer's Disease Brain: Deficiency of Estrogen Receptor-β

(2018) Jiangang Long et al.   JOURNAL OF ALZHEIMERS DISEASE

Biophysical Alterations in Lipid Rafts from Human Cerebral Cortex Associate with Increased BACE1/AβPP Interaction in Early Stages of Alzheimer's Disease

(2018) Mario Díaz et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

Are N- and C-terminally Truncated Aβ species key pathological triggers in Alzheimer’s disease?

(2018) Julie Dunys et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years

(2018) Kevin A. Matthews et al.   Alzheimers & Dementia

Bioenergetic regulation of microglia

(2017) Soumitra Ghosh et al.   GLIA

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Early interleukin-6 enhances hepatic ketogenesis in APP SWE /PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65

(2017) Le Shi et al.   NEUROBIOLOGY OF AGING

Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice

(2017) You-Jin Choi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

APP Function and Lipids: A Bidirectional Link

(2017) Marcus O. W. Grimm et al.   Frontiers in Molecular Neuroscience

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42and Phospho-Tau May Abet Alzheimer Development

(2016) Mini Sajan et al.   DIABETES

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers

(2016) Michelle Perkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting SUMO-1ylation Contrasts Synaptic Dysfunction in a Mouse Model of Alzheimer’s Disease

(2016) Serena Marcelli et al.   MOLECULAR NEUROBIOLOGY

Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer’s Disease-Diabetes Dual Therapy

(2016) Syed Mohd. Danish Rizvi et al.   NEUROCHEMICAL RESEARCH

Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer’s disease

(2016) Eleonora Gatta et al.   PHARMACOLOGICAL RESEARCH

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Interplay between oxidant species and energy metabolism

(2016) Celia Quijano et al.   Redox Biology

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions

(2015) Y. Kizuka et al.   BIOCHEMICAL JOURNAL

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease

(2015) Chris Cadonic et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling

(2015) Jing Liu et al.   MOLECULAR PHARMACEUTICS

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial dysfunction in central nervous system white matter disorders

(2014) Laia Morató et al.   GLIA

Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes

(2014) Joungil Choi et al.   MITOCHONDRION

Neurobiology of food intake in health and disease

(2014) Gregory J. Morton et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease

(2014) Jana Hroudová et al.   Biomed Research International

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

The role of protein glycosylation in Alzheimer disease

(2013) Sophia Schedin-Weiss et al.   FEBS Journal

Mitochondrial degradation during starvation is selective and temporally distinct from bulk autophagy in yeast

(2013) Akinori Eiyama et al.   FEBS LETTERS

Mitochondrial involvement in neurodegenerative diseases

(2013) Gábor Zsurka et al.   IUBMB LIFE

Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes

(2013) Elaine Delvaux et al.   NEUROBIOLOGY OF AGING

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

Glucose Levels and Risk of Dementia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial-associated metabolic disorders: foundations, pathologies and recent progress

(2013) Joseph McInnes   Nutrition & Metabolism

Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics

(2013) Eugenia Trushina et al.   PLoS One

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

(2013) E. Hudry et al.   Science Translational Medicine

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Peripheral Mitochondrial Dysfunction in Alzheimer’s Disease: Focus on Lymphocytes

(2012) Kristina Leuner et al.   MOLECULAR NEUROBIOLOGY

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Mitochondrial Mutations

(2011) Nichola Z. Lax et al.   NEUROSCIENTIST

Mitochondrial dysfunction in neurodegenerative diseases and cancer

(2010) Michelle Barbi de Moura et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Calcium hypothesis of Alzheimer’s disease

(2009) Michael J. Berridge   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

(2008) Alex E. Roher et al.   Alzheimers & Dementia

SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice

(2008) Kaoru Takahashi et al.   NEUROSCIENCE LETTERS

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

(2008) W. S. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA