Neurobiology of food intake in health and disease

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

(2013) Michael J. Krashes et al.   Cell Metabolism

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

(2013) Joshua P. Thaler et al.   DIABETES

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features

(2013) Amélie Bonnefond et al.   JOURNAL OF CLINICAL INVESTIGATION

Rare variants in single-minded 1 (SIM1) are associated with severe obesity

(2013) Shwetha Ramachandrappa et al.   JOURNAL OF CLINICAL INVESTIGATION

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis

(2013) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic identification of a neural circuit that suppresses appetite

(2013) Matthew E. Carter et al.   NATURE

Optogenetic pharmacology for control of native neuronal signaling proteins

(2013) Richard H Kramer et al.   NATURE NEUROSCIENCE

Targeting neurons and photons for optogenetics

(2013) Adam M Packer et al.   NATURE NEUROSCIENCE

Role of oxytocin signaling in the regulation of body weight

(2013) James E. Blevins et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Neuronal circuits that regulate feeding behavior and metabolism

(2013) Jong-Woo Sohn et al.   TRENDS IN NEUROSCIENCES

Regional brain response to visual food cues is a marker of satiety that predicts food choice

(2012) Sonya Mehta et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

(2012) Karen K. Ryan et al.   Cell Metabolism

All Bariatric Surgeries Are Not Created Equal: Insights from Mechanistic Comparisons

(2012) Margaret A. Stefater et al.   ENDOCRINE REVIEWS

Deciphering a neuronal circuit that mediates appetite

(2012) Qi Wu et al.   NATURE

Deconstruction of a neural circuit for hunger

(2012) Deniz Atasoy et al.   NATURE

Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance

(2012) Rebecca L Leshan et al.   NATURE MEDICINE

The contribution of brain reward circuits to the obesity epidemic

(2012) Eric Stice et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats

(2011) Gregory J. Morton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Food reward, hyperphagia, and obesity

(2011) Hans-Rudolf Berthoud et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The physiology and pathophysiology of the neural control of the counterregulatory response

(2011) Craig Beall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

Minireview: The Value of Looking Backward: The Essential Role of the Hindbrain in Counterregulatory Responses to Glucose Deficit

(2011) Sue Ritter et al.   ENDOCRINOLOGY

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Sixteen years and counting: an update on leptin in energy balance

(2011) Laurent Gautron et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucagon-Like Peptide 1 Receptors in Nucleus Accumbens Affect Food Intake

(2011) A. M. Dossat et al.   JOURNAL OF NEUROSCIENCE

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial

(2011) Kishore M Gadde et al.   LANCET

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

GLP-1 and energy balance: an integrated model of short-term and long-term control

(2011) Jason G. Barrera et al.   Nature Reviews Endocrinology

Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

(2011) Jong-Woo Sohn et al.   NEURON

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

(2010) Matthew R. Hayes et al.   Cell Metabolism

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

Hypoglycemia in Type 1 Diabetes

(2010) R. J. McCrimmon et al.   DIABETES

Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia

(2010) Jonathan P. German et al.   ENDOCRINOLOGY

The Epidemiology of Obesity

(2010) Dang M. Nguyen et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Adaptive thermogenesis in humans

(2010) M Rosenbaum et al.   INTERNATIONAL JOURNAL OF OBESITY

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

(2010) Laurence E. Ring et al.   JOURNAL OF CLINICAL INVESTIGATION

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

Neuronal regulation of homeostasis by nutrient sensing

(2010) Tony K T Lam   NATURE MEDICINE

Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management

(2010) Steven R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Energy regulatory signals and food reward

(2010) Dianne P. Figlewicz et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Hypothalamic mechanisms in cachexia

(2010) Aaron J. Grossberg et al.   PHYSIOLOGY & BEHAVIOR

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

(2010) T. Fujikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pathophysiology and treatment of inflammatory anorexia in chronic disease

(2010) Theodore P. Braun et al.   Journal of Cachexia Sarcopenia and Muscle

Differences in attention to food and food intake between overweight/obese and normal-weight females under conditions of hunger and satiety

(2009) Ilse M.T. Nijs et al.   APPETITE

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

(2009) Gina M. Leinninger et al.   Cell Metabolism

Sweet talk in the brain: Glucosensing, neural networks, and hypoglycemic counterregulation

(2009) Alan G. Watts et al.   FRONTIERS IN NEUROENDOCRINOLOGY

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

(2009)   LANCET

Low Sympathetic Tone and Obese Phenotype in Oxytocin-deficient Mice

(2009) Claudia Camerino   Obesity

Corrective responses in human food intake identified from an analysis of 7-d food-intake records

(2008) George A Bray et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

(2008) Diana L. Williams et al.   ENDOCRINOLOGY

Oxytocin Deficiency Mediates Hyperphagic Obesity ofSim1Haploinsufficient Mice

(2008) Bassil M. Kublaoui et al.   MOLECULAR ENDOCRINOLOGY

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Oxytocin receptor-deficient mice developed late-onset obesity

(2008) Yuki Takayanagi et al.   NEUROREPORT

Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

(2007) Esther van de Wall et al.   ENDOCRINOLOGY