Preclinical Models of Visceral Sarcomas

Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell‐derived neural crest cells

(2023) Kyosuke Mukae et al.   CANCER SCIENCE

Synovial Sarcoma Preclinical Modeling: Integrating Transgenic Mouse Models and Patient-Derived Models for Translational Research

(2023) Lorena Landuzzi et al.   Cancers

Photon and Proton irradiation in Patient-derived, Three-Dimensional Soft Tissue Sarcoma Models

(2023) Siyer Roohani et al.   BMC CANCER

Editorial: Patient-derived tumor models for drug development

(2023) Hatim E. Sabaawy et al.   Frontiers in Oncology

Current molecular and therapeutic advances in liposarcoma, rhabdomyosarcoma, leiomyosarcoma, synovial sarcoma, and angiosarcoma

(2022) Ozgur Tanriverdi et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Preclinical Modeling of Leiomyosarcoma Identifies Susceptibility to Transcriptional CDK Inhibitors through Antagonism of E2F-Driven Oncogenic Gene Expression

(2022) Matthew L. Hemming et al.   CLINICAL CANCER RESEARCH

Patient Derived Ex-Vivo Cancer Models in Drug Development, Personalized Medicine, and Radiotherapy

(2022) Ryan Zitter et al.   Cancers

Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation

(2021) Valentina Zuco et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Preclinical In Vivo Modeling of Pediatric Sarcoma—Promises and Limitations

(2021) Roland Imle et al.   Journal of Clinical Medicine

Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

(2021) A. Gronchi et al.   ANNALS OF ONCOLOGY

Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2021) P.G. Casali et al.   ANNALS OF ONCOLOGY

Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors

(2021) Fabio Vanoli et al.   ONCOGENE

Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

(2021) Javier Escudero et al.   Cancer Cell International

Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells

(2021) Takafumi Shima et al.   ONCOLOGY REPORTS

Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome

(2021) Brittany E. Jewell et al.   PLoS Genetics

The role of novel fusion genes in human GIST cell lines derived from imatinib-resistant GIST patients: A therapeutic potential of fusion gene

(2020) Woo-Cheol Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Three-Dimensional Culture System of Cancer Cells Combined with Biomaterials for Drug Screening

(2020) Teruki Nii et al.   Cancers

HSP90 identified by a proteomic approach as druggable target to reverse platinum resistance in ovarian cancer

(2020) Rita Lombardi et al.   Molecular Oncology

Systematic Review of the Current Status of Human Sarcoma Cell Lines

(2019) Emi Hattori et al.   Cells

First-Line Therapy for Metastatic Soft Tissue Sarcoma

(2019) Megan Meyer et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas

(2019) Bertha A. Brodin et al.   BRITISH JOURNAL OF CANCER

Establishment and characterization of histologically and molecularly stable soft tissue sarcoma xenograft models for biological studies and preclinical drug testing

(2019) Jasmien Cornillie et al.   MOLECULAR CANCER THERAPEUTICS

Development of mouse models of angiosarcoma driven by p53

(2019) Donald M. Salter et al.   Disease Models & Mechanisms

Comparative Assessment of Antitumor Effects and Autophagy Induction as a Resistance Mechanism by Cytotoxics and EZH2 Inhibition in INI1-Negative Epithelioid Sarcoma Patient-Derived Xenograft

(2019) Silvia Stacchiotti et al.   Cancers

A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation

(2019) François Le Loarer et al.   MODERN PATHOLOGY

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

(2018) Minan Wang et al.   FASEB JOURNAL

Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome

(2018) Matthew L. Hemming et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of soft-tissue sarcomas: translation of biological advances into treatment measures

(2018) Ngoc T Hoang et al.   Cancer Management and Research

Transgenic Mouse Models in Cancer Research

(2018) Ursa Lampreht Tratar et al.   Frontiers in Oncology

Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression

(2018) Yuqing Tu et al.   CELL CYCLE

Soft Tissue Sarcoma Cancer Stem Cells: An Overview

(2018) Katia C. Genadry et al.   Frontiers in Oncology

Zebrafish xenograft models of cancer and metastasis for drug discovery

(2017) Hannah K Brown et al.   Expert Opinion on Drug Discovery

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging

(2017) Marisa R. Buchakjian et al.   PLoS One

Managing sarcoma: where have we come from and where are we going?

(2017) Jenna S. Bleloch et al.   Therapeutic Advances in Medical Oncology

Three-Dimensional Patient-Derived In Vitro Sarcoma Models: Promising Tools for Improving Clinical Tumor Management

(2017) Manuela Gaebler et al.   Frontiers in Oncology

Establishment and molecular characterisation of seven novel soft-tissue sarcoma cell lines

(2016) Abdulazeez Salawu et al.   BRITISH JOURNAL OF CANCER

Patient-derived xenografts: a relevant preclinical model for drug development

(2016) Luca Pompili et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cabozantinib Is Active against Human Gastrointestinal Stromal Tumor Xenografts Carrying Different KIT Mutations

(2016) Yemarshet K. Gebreyohannes et al.   MOLECULAR CANCER THERAPEUTICS

Patient-derived induced pluripotent stem cells in cancer research and precision oncology

(2016) Eirini P Papapetrou   NATURE MEDICINE

An EWS-FLI1 -Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development

(2016) Shingo Komura et al.   Stem Cell Reports

Modeling Familial Cancer with Induced Pluripotent Stem Cells

(2015) Dung-Fang Lee et al.   CELL

Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA Expression

(2015) B. A. Teicher et al.   MOLECULAR CANCER THERAPEUTICS

Genomic landscape of liposarcoma

(2015) Deepika Kanojia et al.   Oncotarget

SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier

(2015) Sakura Tamaki et al.   PLoS One

Phosphoinositide 3-Kinase Inhibitors Combined with Imatinib in Patient-Derived Xenograft Models of Gastrointestinal Stromal Tumors: Rationale and Efficacy

(2014) T. Van Looy et al.   CLINICAL CANCER RESEARCH

Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients

(2014) A. P. Garner et al.   CLINICAL CANCER RESEARCH

TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

(2014) Christian Koelsche et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pazopanib, a Receptor Tyrosine Kinase Inhibitor, Suppresses Tumor Growth through Angiogenesis in Dedifferentiated Liposarcoma Xenograft Models

(2014) Haifu Li et al.   Translational Oncology

Novel Dedifferentiated Liposarcoma Xenograft Models Reveal PTEN Down-Regulation as a Malignant Signature and Response to PI3K Pathway Inhibition

(2013) Kathleen B. Smith et al.   AMERICAN JOURNAL OF PATHOLOGY

Gastrointestinal Stromal Tumors

(2013) Markku Miettinen et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

The Clinical Relevance of Cancer Cell Lines

(2013) J.-P. Gillet et al.   JNCI-Journal of the National Cancer Institute

Sorafenib Inhibits Many Kinase Mutations Associated with Drug-Resistant Gastrointestinal Stromal Tumors

(2012) M. C. Heinrich et al.   MOLECULAR CANCER THERAPEUTICS

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Metabolomics Strategy Reveals Subpopulation of Liposarcomas Sensitive to Gemcitabine Treatment

(2012) D. Braas et al.   Cancer Discovery

Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations

(2011) Stine H. Kresse et al.   CANCER

Small RNA Sequencing and Functional Characterization Reveals MicroRNA-143 Tumor Suppressor Activity in Liposarcoma

(2011) S. Ugras et al.   CANCER RESEARCH

Expression Profiling of Liposarcoma Yields a Multigene Predictor of Patient Outcome and Identifies Genes That Contribute to Liposarcomagenesis

(2011) R. M. Gobble et al.   CANCER RESEARCH

Restoration of C/EBPα in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis

(2011) Yuhsin V. Wu et al.   GENES CHROMOSOMES & CANCER

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent Alterations and Epigenetic Silencing of Differentiation Pathway Genes in Structurally Rearranged Liposarcomas

(2011) B. S. Taylor et al.   Cancer Discovery

Local Mesenchymal Stem/Progenitor Cells Are a Preferential Target for Initiation of Adult Soft Tissue Sarcomas Associated with p53 and Rb Deficiency

(2010) Jinhyang Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Patterning network structure to spatially control cellular remodeling and stem cell fate within 3-dimensional hydrogels

(2010) Sudhir Khetan et al.   BIOMATERIALS

ZIC1 Overexpression Is Oncogenic in Liposarcoma

(2010) E. Brill et al.   CANCER RESEARCH

A decade of tyrosine kinase inhibitor therapy: Historical and current perspectives on targeted therapy for GIST

(2010) Jean-Yves Blay   CANCER TREATMENT REVIEWS

Animal models of soft-tissue sarcoma

(2010) R. D. Dodd et al.   Disease Models & Mechanisms

Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

(2009) K. Nishijo et al.   CANCER RESEARCH

Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors

(2009) T. Muhlenberg et al.   CANCER RESEARCH

High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model

(2009) G. Floris et al.   CLINICAL CANCER RESEARCH

Mouse xenograft models vs GEM models for human cancer therapeutics

(2008) A. Richmond et al.   Disease Models & Mechanisms

Chemotherapeutic Management of Soft Tissue Sarcoma

(2008) Katherine Thornton   SURGICAL CLINICS OF NORTH AMERICA

Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line

(2007) Fredrik Persson et al.   CANCER LETTERS