Synovial Sarcoma Preclinical Modeling: Integrating Transgenic Mouse Models and Patient-Derived Models for Translational Research

Soft-tissue sarcoma in adolescents and young adults

(2022) Toshiyuki Kunisada et al.   International Journal of Clinical Oncology

SS18-SSX drives CREB activation in synovial sarcoma

(2022) Magdalene Cyra et al.   CELLULAR ONCOLOGY

Establishment and characterization of NCC-SS5-C1: a novel patient-derived cell line of synovial sarcoma

(2022) Yuki Yoshimatsu et al.   Human Cell

Expanding the Use of an SS18-SSX Antibody for Molecular Assays in Synovial Sarcoma

(2022) Ainiah Rushdiana Raquib et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Characterisation of a Novel Cell Line (ICR-SS-1) Established from a Patient-Derived Xenograft of Synovial Sarcoma

(2022) William G. J. Kerrison et al.   Cells

Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma

(2022) Alexandra Gyurdieva et al.   Nature Communications

Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma

(2021) Livnat Jerby-Arnon et al.   NATURE MEDICINE

Early stability and late random tumor progression of a HER2-positive primary breast cancer patient-derived xenograft

(2021) Lorena Landuzzi et al.   Scientific Reports

Establishment and characterization of NCC-SS4-C1: a novel patient-derived cell line of synovial sarcoma

(2021) Ryuto Tsuchiya et al.   Human Cell

Patient Derived Xenografts for Genome-Driven Therapy of Osteosarcoma

(2021) Lorena Landuzzi et al.   Cells

Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes

(2021) Juan A. Marín-Jiménez et al.   Frontiers in Immunology

Preclinical In Vivo Modeling of Pediatric Sarcoma—Promises and Limitations

(2021) Roland Imle et al.   Journal of Clinical Medicine

Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA

(2021) Carter K. Fairchild et al.   Cancers

International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer

(2021) Gilles Vassal et al.   MOLECULAR CANCER THERAPEUTICS

A role for SMARCB1 in synovial sarcomagenesis reveals that SS18-SSX induces canonical BAF destruction

(2021) Jinxiu Li et al.   Cancer Discovery

HER Tyrosine Kinase Family and Rhabdomyosarcoma: Role in Onset and Targeted Therapy

(2021) Carla De Giovanni et al.   Cells

Turning ‘Cold’ tumors ‘Hot’: immunotherapies in sarcoma

(2021) Jeff Rytlewski et al.   Annals of Translational Medicine

The Biology of Synovial Sarcoma: State-of-the-Art and Future Perspectives

(2021) Michele Fiore et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Chemosensitivity of Lung Metastatic High-Grade Synovial Sarcoma

(2021) Cecilia Tetta et al.   Journal of Clinical Medicine

Establishment and characterization of NCC-SS3-C1: a novel patient-derived cell line of synovial sarcoma

(2020) Yuki Yoshimatsu et al.   Human Cell

Biological features of tissue and bone sarcomas investigated using an in vitro model of clonal selection

(2020) N.A. Avdonkina et al.   PATHOLOGY RESEARCH AND PRACTICE

Systematic Review of the Current Status of Human Sarcoma Cell Lines

(2019) Emi Hattori et al.   Cells

Overactive IGF1/Insulin Receptors and NRASQ61R Mutation Drive Mechanisms of Resistance to Pazopanib and Define Rational Combination Strategies to Treat Synovial Sarcoma

(2019) Cinzia Lanzi et al.   Cancers

SS18-SSX-dependent YAP/TAZ Signaling in Synovial Sarcoma

(2019) Ilka Isfort et al.   CLINICAL CANCER RESEARCH

Establishment and characterization of histologically and molecularly stable soft tissue sarcoma xenograft models for biological studies and preclinical drug testing

(2019) Jasmien Cornillie et al.   MOLECULAR CANCER THERAPEUTICS

Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

(2019) Patrizia Nanni et al.   Scientific Reports

Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma

(2019) Indu Ramachandran et al.   Journal for ImmunoTherapy of Cancer

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma

(2018) Ana Banito et al.   CANCER CELL

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases

(2018) Giuliana Cassinelli et al.   CANCER LETTERS

Systemic Treatment for Adults with Synovial Sarcoma

(2018) Ingrid M. E. Desar et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Establishment and proteomic characterization of a novel synovial sarcoma cell line, NCC-SS2-C1

(2018) Rieko Oyama et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Synovial Sarcoma: Current Concepts and Future Perspectives

(2018) Silvia Stacchiotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Patient-derived xenograft models in musculoskeletal malignancies

(2018) Wan Lu et al.   Journal of Translational Medicine

Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials

(2018) Sandra P D'Angelo et al.   LANCET ONCOLOGY

Establishment and characterization of the NCC–SS1–C1 synovial sarcoma cell line

(2018) Fusako Kito et al.   Human Cell

Genome-Informed Targeted Therapy for Osteosarcoma

(2018) Leanne C Sayles et al.   Cancer Discovery

PDX Finder: A portal for patient-derived tumor xenograft model discovery

(2018) Nathalie Conte et al.   NUCLEIC ACIDS RESEARCH

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

(2018) Gerard L Brien et al.   eLife

Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells

(2017) Jared J. Barrott et al.   JOURNAL OF CLINICAL INVESTIGATION

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial

(2017) Hussein A Tawbi et al.   LANCET ONCOLOGY

The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis

(2017) Jared J. Barrott et al.   MOLECULAR CANCER RESEARCH

Death by HDAC Inhibition in Synovial Sarcoma Cells

(2017) Aimée N. Laporte et al.   MOLECULAR CANCER THERAPEUTICS

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma

(2017) Jianguo Huang et al.   Nature Communications

Proteomic approach toward determining the molecular background of pazopanib resistance in synovial sarcoma

(2017) Zhiwei Qiao et al.   Oncotarget

HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma

(2017) Aimée N. Laporte et al.   PLoS One

The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities

(2016) Elizabeth Stewart et al.   DEVELOPMENTAL BIOLOGY

Outcome of chemotherapy in advanced synovial sarcoma patients: Review of 15 clinical trials from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group; setting a new landmark for studies in this entity

(2016) Myrella Vlenterie et al.   EUROPEAN JOURNAL OF CANCER

Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor

(2016) Hiroyuki Yamasaki et al.   GENES TO CELLS

Modeling synovial sarcoma metastasis in the mouse: PI3′-lipid signaling and inflammation

(2016) Jared J. Barrott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states

(2016) Cigall Kadoch et al.   NATURE GENETICS

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis

(2016) K B Jones et al.   ONCOGENE

Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

(2016) Satoshi Kawano et al.   PLoS One

Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA Expression

(2015) B. A. Teicher et al.   MOLECULAR CANCER THERAPEUTICS

Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for Therapy

(2015) Torsten O. Nielsen et al.   Cancer Discovery

β-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition

(2015) Jared J. Barrott et al.   Oncotarget

Synovial sarcoma in children and adolescents: the European Pediatric Soft Tissue Sarcoma Study Group prospective trial (EpSSG NRSTS 2005)

(2014) A. Ferrari et al.   ANNALS OF ONCOLOGY

Patient-derived xenografts for individualized care in advanced sarcoma

(2014) Justin Stebbing et al.   CANCER

Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment

(2014) Matthew L. Goodwin et al.   CANCER CELL

A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response

(2014) P. F. Robbins et al.   CLINICAL CANCER RESEARCH

TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

(2014) Christian Koelsche et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Modeling Clear Cell Sarcomagenesis in the Mouse: Cell of Origin Differentiation State Impacts Tumor Characteristics

(2013) Krystal M. Straessler et al.   CANCER CELL

Loss of SS18-SSX1 Inhibits Viability and Induces Apoptosis in Synovial Sarcoma

(2013) Emily E. Carmody Soni et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Targeting the Wnt Pathway in Synovial Sarcoma Models

(2013) W. Barham et al.   Cancer Discovery

Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue

(2012) David J Monsma et al.   Journal of Translational Medicine

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas

(2012) K B Jones et al.   ONCOGENE

Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma

(2011) Hao-Wei Teng et al.   JOURNAL OF SURGICAL ONCOLOGY

Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT–SSX2

(2011) C B Garcia et al.   ONCOGENE

Animal models of soft-tissue sarcoma

(2010) R. D. Dodd et al.   Disease Models & Mechanisms

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

(2010) Jordi Barretina et al.   NATURE GENETICS

EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor

(2010) L Su et al.   ONCOGENE

Synovial Sarcoma is a Stem Cell Malignancy

(2010) Norifumi Naka et al.   STEM CELLS

Synovial sarcoma

(2009) Emanuela Palmerini et al.   CANCER

A CreER-Based Random Induction Strategy for Modeling Translocation-Associated Sarcomas in Mice

(2009) M. Haldar et al.   CANCER RESEARCH